ID F7V043_EEGSY Unreviewed; 320 AA. AC F7V043; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 07-APR-2021, entry version 54. DE RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808}; GN Name=XerC {ECO:0000313|EMBL:BAK44136.1}; GN Synonyms=xerC {ECO:0000256|HAMAP-Rule:MF_01808}; GN OrderedLocusNames=EGYY_09490 {ECO:0000313|EMBL:BAK44136.1}; OS Eggerthella sp. (strain YY7918). OC Bacteria; Actinobacteria; Coriobacteriia; Eggerthellales; Eggerthellaceae; OC Eggerthella; unclassified Eggerthella. OX NCBI_TaxID=502558 {ECO:0000313|EMBL:BAK44136.1, ECO:0000313|Proteomes:UP000008929}; RN [1] {ECO:0000313|EMBL:BAK44136.1, ECO:0000313|Proteomes:UP000008929} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YY7918 {ECO:0000313|EMBL:BAK44136.1, RC ECO:0000313|Proteomes:UP000008929}; RX PubMed=21914883; RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.; RT "Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp. RT Strain YY7918, Isolated from Adult Human Intestine."; RL J. Bacteriol. 193:5570-5571(2011). RN [2] {ECO:0000313|Proteomes:UP000008929} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YY7918 {ECO:0000313|Proteomes:UP000008929}; RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.; RT "Complete genome sequence of the equol-producing bacterium Eggerthella sp. RT strain YY7918 isolated from adult human intestine."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. The XerC- CC XerD complex is essential to convert dimers of the bacterial chromosome CC into monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. CC {ECO:0000256|HAMAP-Rule:MF_01808}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP- CC Rule:MF_01808}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_01808}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily. CC {ECO:0000256|HAMAP-Rule:MF_01808}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerD subfamily. CC {ECO:0000256|ARBA:ARBA00010450}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP012211; BAK44136.1; -; Genomic_DNA. DR STRING; 502558.EGYY_09490; -. DR KEGG; eyy:EGYY_09490; -. DR eggNOG; COG4974; Bacteria. DR HOGENOM; CLU_027562_9_0_11; -. DR OMA; FASHMLE; -. DR Proteomes; UP000008929; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR InterPro; IPR044068; CB. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. DR PROSITE; PS51900; CB; 1. DR PROSITE; PS51898; TYR_RECOMBINASE; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP- KW Rule:MF_01808}; KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP- KW Rule:MF_01808}; KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP- KW Rule:MF_01808}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01808}; KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP- KW Rule:MF_01808}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP- KW Rule:MF_01808}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_01808}; Reference proteome {ECO:0000313|Proteomes:UP000008929}. FT DOMAIN 22..108 FT /note="Core-binding (CB)" FT /evidence="ECO:0000259|PROSITE:PS51900" FT DOMAIN 129..313 FT /note="Tyr recombinase" FT /evidence="ECO:0000259|PROSITE:PS51898" FT ACT_SITE 169 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 193 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 265 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 268 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 291 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 300 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" SQ SEQUENCE 320 AA; 35964 MW; C3F066EADB0FFE9E CRC64; MRLLKQMEWQ RVGRGREAAV KAGMDELIQE YLAHLRVERG SSPLTVSAYG RDLHDYAAFL HEKGIDRIDD IDRDVLVSYE SDLLKRGYAT SSIDRRISVL KGFHKFLVRE GFTRRNPADT LQLPKAPERL PDVLSIDQMN AMLSQPLESG PLPLRDRAIL EVLYGCGLRV SECTGLDLGD VSFDEGYLRI LGKGRKERLT PISGAALRAL VEYRDHARGE LMKPYAKPTS AVFLNARGGR LTRQSVHAIV ARAGLTIGVE NLHPHTLRHS FATHLLEGGA DLRVIQEMLG HSDISTTQIY THVNRSHIRA EYLHAHPRAR //