ID F7V043_EEGSY Unreviewed; 320 AA. AC F7V043; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 11-JUN-2014, entry version 17. DE RecName: Full=Tyrosine recombinase XerC; GN Name=XerC; Synonyms=xerC, xerC2; OrderedLocusNames=EGYY_09490; OS Eggerthella sp. (strain YY7918). OC Bacteria; Actinobacteria; Coriobacteridae; Coriobacteriales; OC Coriobacterineae; Coriobacteriaceae; Eggerthella. OX NCBI_TaxID=502558; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YY7918; RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.; RT "Complete genome sequence of the equol-producing bacterium Eggerthella RT sp. strain YY7918 isolated from adult human intestine."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by CC catalyzing the cutting and rejoining of the recombining DNA CC molecules. The XerC-XerD complex is essential to convert dimers of CC the bacterial chromosome into monomers to permit their segregation CC at cell division. It also contributes to the segregational CC stability of plasmids (By similarity). CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC CC subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP012211; BAK44136.1; -; Genomic_DNA. DR RefSeq; YP_004710537.1; NC_015738.1. DR EnsemblBacteria; BAK44136; BAK44136; EGYY_09490. DR GeneID; 10927260; -. DR KEGG; eyy:EGYY_09490; -. DR KO; K04763; -. DR BioCyc; ESP502558:GI1S-862-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-HAMAP. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-HAMAP. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-HAMAP. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat-core. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR023109; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011932; Recomb_XerD. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02225; recomb_XerD; 1. PE 3: Inferred from homology; KW Cell cycle; Cell division; Chromosome partition; Complete proteome; KW Cytoplasm; DNA integration; DNA recombination; DNA-binding. FT ACT_SITE 169 169 By similarity{EA12}. FT ACT_SITE 193 193 By similarity{EA12}. FT ACT_SITE 265 265 By similarity{EA12}. FT ACT_SITE 268 268 By similarity{EA12}. FT ACT_SITE 291 291 By similarity{EA12}. FT ACT_SITE 300 300 O-(3'-phospho-DNA)-tyrosine intermediate FT (By similarity){EA12}. SQ SEQUENCE 320 AA; 35964 MW; C3F066EADB0FFE9E CRC64; MRLLKQMEWQ RVGRGREAAV KAGMDELIQE YLAHLRVERG SSPLTVSAYG RDLHDYAAFL HEKGIDRIDD IDRDVLVSYE SDLLKRGYAT SSIDRRISVL KGFHKFLVRE GFTRRNPADT LQLPKAPERL PDVLSIDQMN AMLSQPLESG PLPLRDRAIL EVLYGCGLRV SECTGLDLGD VSFDEGYLRI LGKGRKERLT PISGAALRAL VEYRDHARGE LMKPYAKPTS AVFLNARGGR LTRQSVHAIV ARAGLTIGVE NLHPHTLRHS FATHLLEGGA DLRVIQEMLG HSDISTTQIY THVNRSHIRA EYLHAHPRAR //