ID   F7V043_EEGSY            Unreviewed;       320 AA.
AC   F7V043;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   11-JUN-2014, entry version 17.
DE   RecName: Full=Tyrosine recombinase XerC;
GN   Name=XerC; Synonyms=xerC, xerC2; OrderedLocusNames=EGYY_09490;
OS   Eggerthella sp. (strain YY7918).
OC   Bacteria; Actinobacteria; Coriobacteridae; Coriobacteriales;
OC   Coriobacterineae; Coriobacteriaceae; Eggerthella.
OX   NCBI_TaxID=502558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YY7918;
RA   Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT   "Complete genome sequence of the equol-producing bacterium Eggerthella
RT   sp. strain YY7918 isolated from adult human intestine.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids (By similarity).
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily.
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DR   EMBL; AP012211; BAK44136.1; -; Genomic_DNA.
DR   RefSeq; YP_004710537.1; NC_015738.1.
DR   EnsemblBacteria; BAK44136; BAK44136; EGYY_09490.
DR   GeneID; 10927260; -.
DR   KEGG; eyy:EGYY_09490; -.
DR   KO; K04763; -.
DR   BioCyc; ESP502558:GI1S-862-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-HAMAP.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat-core.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR023109; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR011932; Recomb_XerD.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   TIGRFAMs; TIGR02225; recomb_XerD; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; Complete proteome;
KW   Cytoplasm; DNA integration; DNA recombination; DNA-binding.
FT   ACT_SITE    169    169       By similarity{EA12}.
FT   ACT_SITE    193    193       By similarity{EA12}.
FT   ACT_SITE    265    265       By similarity{EA12}.
FT   ACT_SITE    268    268       By similarity{EA12}.
FT   ACT_SITE    291    291       By similarity{EA12}.
FT   ACT_SITE    300    300       O-(3'-phospho-DNA)-tyrosine intermediate
FT                                (By similarity){EA12}.
SQ   SEQUENCE   320 AA;  35964 MW;  C3F066EADB0FFE9E CRC64;
     MRLLKQMEWQ RVGRGREAAV KAGMDELIQE YLAHLRVERG SSPLTVSAYG RDLHDYAAFL
     HEKGIDRIDD IDRDVLVSYE SDLLKRGYAT SSIDRRISVL KGFHKFLVRE GFTRRNPADT
     LQLPKAPERL PDVLSIDQMN AMLSQPLESG PLPLRDRAIL EVLYGCGLRV SECTGLDLGD
     VSFDEGYLRI LGKGRKERLT PISGAALRAL VEYRDHARGE LMKPYAKPTS AVFLNARGGR
     LTRQSVHAIV ARAGLTIGVE NLHPHTLRHS FATHLLEGGA DLRVIQEMLG HSDISTTQIY
     THVNRSHIRA EYLHAHPRAR
//