ID F7H0I0_MACMU Unreviewed; 1935 AA. AC F7H0I0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 10-MAY-2017, entry version 43. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000039566}; GN Name=ADAMTS9 {ECO:0000313|Ensembl:ENSMMUP00000039566}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000039566, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000039566, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000039566, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000039566} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000039566}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000039566}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JSUE03023475; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03023476; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03023477; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; JSUE03023478; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_014985954.1; XM_015130468.1. DR RefSeq; XP_014985954.1; XM_015130468.1. DR RefSeq; XP_014985954.1; XM_015130468.1. DR UniGene; Mmu.24254; -. DR ProteinModelPortal; F7H0I0; -. DR STRING; 9544.ENSMMUP00000039566; -. DR MEROPS; M12.021; -. DR Ensembl; ENSMMUT00000046533; ENSMMUP00000039566; ENSMMUG00000000265. DR GeneID; 698341; -. DR KEGG; mcc:698341; -. DR CTD; 56999; -. DR eggNOG; KOG3538; Eukaryota. DR eggNOG; ENOG410XPKZ; LUCA. DR GeneTree; ENSGT00760000118880; -. DR InParanoid; F7H0I0; -. DR KO; K08624; -. DR OMA; QVCPYMM; -. DR OrthoDB; EOG091G00AX; -. DR TreeFam; TF331949; -. DR Proteomes; UP000006718; Chromosome 2. DR Bgee; ENSMMUG00000000265; -. DR ExpressionAtlas; F7H0I0; baseline. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IEA:Ensembl. DR GO; GO:0005578; C:proteinaceous extracellular matrix; IEA:Ensembl. DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl. DR Gene3D; 2.20.100.10; -; 15. DR Gene3D; 3.40.390.10; -; 1. DR InterPro; IPR010294; ADAM_spacer1. DR InterPro; IPR024079; MetalloPept_cat_dom. DR InterPro; IPR012314; Pept_M12B_GON-ADAMTSs. DR InterPro; IPR001590; Peptidase_M12B. DR InterPro; IPR013273; Peptidase_M12B_ADAM-TS. DR InterPro; IPR002870; Peptidase_M12B_N. DR InterPro; IPR000884; TSP1_rpt. DR Pfam; PF05986; ADAM_spacer1; 1. DR Pfam; PF08685; GON; 1. DR Pfam; PF01562; Pep_M12B_propep; 1. DR Pfam; PF01421; Reprolysin; 1. DR Pfam; PF00090; TSP_1; 13. DR PRINTS; PR01857; ADAMTSFAMILY. DR SMART; SM00209; TSP1; 15. DR SUPFAM; SSF82895; SSF82895; 14. DR PROSITE; PS50215; ADAM_MEPRO; 1. DR PROSITE; PS51046; GON; 1. DR PROSITE; PS50092; TSP1; 14. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00517240}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}; KW Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 1935 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008957274. FT DOMAIN 293 499 Peptidase M12B. {ECO:0000259|PROSITE: FT PS50215}. FT DOMAIN 1735 1935 GON. {ECO:0000259|PROSITE:PS51046}. FT ACT_SITE 435 435 {ECO:0000256|PROSITE-ProRule:PRU00276}. FT METAL 434 434 Zinc; catalytic. {ECO:0000256|PROSITE- FT ProRule:PRU00276}. FT METAL 438 438 Zinc; catalytic. {ECO:0000256|PROSITE- FT ProRule:PRU00276}. FT METAL 444 444 Zinc; catalytic. {ECO:0000256|PROSITE- FT ProRule:PRU00276}. SQ SEQUENCE 1935 AA; 216557 MW; C3A6C7D96FD41F27 CRC64; MQFVSWATLL TLLVRDLAEM GIPDAAAAVR KDRLHPRQVK LLETLSEYEI VSPIRVNALG EPFPTNVHFK RRRRSINSAT DPWPAFASSS SSSTSSQAHY RLSAFGQQFL FNLTANAGFI APLFTVTLLG TPGVNQTKFY SEEEAELKHC FYKGYVNTKS EHTAVISLCS GMLGTFRSYD GDYFIEPLQS MDEQEDEEEQ NKPHIIYRRS TPQREPSTGR HACDTSEHKN RHSKDKKKTR ARKWGERINL ADDVAALNSG LATEAFSAYG NKTDNTTEKR THRRTKRFLS YPRFVEVLVV ADNRMVSYHG ENLQHYILTL MSIVASIYKD PSIGNLINIV IVNLIVIHNE QDGPSISFNA QTTLKNFCQW QHSKNSPGGI HHDTAVLLTR QDICRAHDKC DTLGLAELGT ICDPYRSCSI SEDSGLSTAF TIAHELGHVF NMPHDDNNKC KEEGVKSPQH VMAPTLNFYT NPWMWSKCSR KYITEFLDTG YGECLLNEPE SRPYPLPVQL PGILYNVNKQ CELIFGPGSQ VCPYMMQCRR LWCNNVNGVH KGCRTQHTPW ADGTECEPGK HCKYGFCVPK EMDVPVTDGS WGSWSPFGTC SRTCGGGIKT AIRECNRPEP KNGGKYCVGR RMKFKSCNTE PCLKQKRDFR DEQCAHFDGK HFNINGLLPN VRWVPKYSGI LMKDRCKLFC RVAGNTAYYQ LRDRVIDGTP CGQDTNDICV QGLCRQAGCD HVLNSKARRD KCGVCGGDNS SCKTVAGTFN TVHYGYNTVV RIPAGATNID VRQHSFSGET DDDNYLALSS SKGEFLLNGN FVVTMAKREI RIGNAVVEYS GSETAVERIN STDRIEQELL LQVLSVGKLY NPDVRYSFNI PIEDKPQQFY WNSHGPWQAC SKPCQGERKR KLVCTRESDQ LTVSDQRCDR LPQPGPITEP CGTDCDLRWH VASRSECSAQ CGLGYRTLDI YCAKYSRLDG KTEKVDDGFC SSHPKPSNRE KCSGECNTGG WRYSAWTECS KSCDGGTQRR RAICVNTRND VLDDSKCTHQ EKVTIQRCSE FPCPQWKSGD WSECLVTCGK GHKHRQVWCQ FGEDRLNDRM CDPETKPTSM QTCQQPECAS WQAGPWGQCS VTCGQGYQLR AVKCIIGTYM SVVDDNDCNA ATRPTDTQDC ELPSCHPPPA APETRRSTYS APRTQWRFGS WTPCSATCGK GTRMRYVSCR DENGSVADES ACATLPRPVA KEECSVTPCG QWKALDWSSC SVTCGQGRAT RQVVCVNYSD HVIDRSECDQ DYIPETDQDC SMSPCPQRTP DSGLAQHPFQ NEDYRPRSAS PSRTHVLGGN QWRTGPWGAC SSTCAGGSQR RVVVCQDENG YTANDCVERI KPDEQRACES GPCPQWAYGN WGECTKLCGG GIRTRLVVCQ RSNGERFPDL SCEILDKPPD REQCNTHACP HDAAWSTGPW SSCSVSCGRG HKQRNVYCMA KDGSHLESDY CKHLAKPHGH RKCRGGRCPK WKTGAWSQCS VSCGRGVQQR HVGCQIGTHK IARETECNPY TRPESERDCQ GPRCPLYTWR AEEWQECTKT CGEGSRYRKV VCVDDSKNEV HGARCDVSKR PADHESCSLQ PCEYVWITGE WSECSVTCGK GYKQRLVSCS EIYTGKENYE YSYQTTVNCP GTQPPSVHPC YLRECPVSAT WRVGNWGSCS VSCGVGVMQR SVQCLTNEDQ PSHLCHTDLK PEERKTCRNI YNCELPQNCK EVKRLKGASE DGEYFLMIRG KLLKIFCAGM HSDHPKEYVT LVHGDSENFS EVYGHRLHNP TECPYNGSRR DDCQCRKDYT AAGFSSFQKI RIDLTSMQII TTDLQFARTS EGHPVPFATA GDCYSAAKCP QGRFSINLYG TGLSLTESAR WISQGNYAVS DIKKSPDGTR VIGKCGGYCG KCTPSSGTGL EVRVL //