ID F7GUW7_MACMU Unreviewed; 1732 AA. AC F7GUW7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 3. DT 24-JAN-2024, entry version 68. DE SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSMMUP00000002157.4}; GN Name=RICTOR {ECO:0000313|Ensembl:ENSMMUP00000002157.4, GN ECO:0000313|VGNC:VGNC:76853}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002157.4, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000002157.4, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157.4, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A., RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., RA Kuhn R.M., Smith K.E., Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002157.4} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157.4}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the RICTOR family. CC {ECO:0000256|ARBA:ARBA00008878}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_014995411.1; XM_015139925.1. DR STRING; 9544.ENSMMUP00000002157; -. DR PaxDb; 9544-ENSMMUP00000002157; -. DR Ensembl; ENSMMUT00000002281.4; ENSMMUP00000002157.4; ENSMMUG00000001611.4. DR GeneID; 694915; -. DR KEGG; mcc:694915; -. DR CTD; 253260; -. DR VEuPathDB; HostDB:ENSMMUG00000001611; -. DR VGNC; VGNC:76853; RICTOR. DR eggNOG; KOG3694; Eukaryota. DR GeneTree; ENSGT00390000002096; -. DR HOGENOM; CLU_001013_2_0_1; -. DR InParanoid; F7GUW7; -. DR OMA; GRTHEGH; -. DR OrthoDB; 90320at2759; -. DR TreeFam; TF343656; -. DR Proteomes; UP000006718; Chromosome 6. DR Bgee; ENSMMUG00000001611; Expressed in spermatocyte and 21 other cell types or tissues. DR ExpressionAtlas; F7GUW7; baseline and differential. DR GO; GO:0031932; C:TORC2 complex; IBA:GO_Central. DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central. DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl. DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Ensembl. DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IBA:GO_Central. DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:Ensembl. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl. DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0033135; P:regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0038203; P:TORC2 signaling; IBA:GO_Central. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR028268; Pianissimo_fam. DR InterPro; IPR028267; Pianissimo_N. DR InterPro; IPR029453; Rictor_IV. DR InterPro; IPR029451; RICTOR_M. DR InterPro; IPR029259; RICTOR_phospho. DR InterPro; IPR029452; RICTOR_V. DR PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1. DR PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1. DR Pfam; PF14663; RasGEF_N_2; 1. DR Pfam; PF14666; RICTOR_M; 1. DR Pfam; PF14664; RICTOR_N; 1. DR Pfam; PF14665; RICTOR_phospho; 1. DR Pfam; PF14668; RICTOR_V; 1. DR SMART; SM01303; RasGEF_N_2; 1. DR SMART; SM01307; RICTOR_M; 1. DR SMART; SM01308; RICTOR_N; 1. DR SMART; SM01309; RICTOR_phospho; 1. DR SMART; SM01310; RICTOR_V; 1. DR SUPFAM; SSF48371; ARM repeat; 2. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 57..439 FT /note="Rapamycin-insensitive companion of mTOR N-terminal" FT /evidence="ECO:0000259|SMART:SM01308" FT DOMAIN 523..742 FT /note="Rapamycin-insensitive companion of mTOR middle" FT /evidence="ECO:0000259|SMART:SM01307" FT DOMAIN 920..992 FT /note="Rapamycin-insensitive companion of mTOR" FT /evidence="ECO:0000259|SMART:SM01310" FT REGION 1022..1041 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1101..1134 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1194..1240 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1203..1240 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1732 AA; 194910 MW; 6BFA0CDB2FBDC816 CRC64; MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG VSNMRKLGHL NNFTKLLCDI GHSEEKLGFN YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV LKLKVDYLIA RCIDIQQSNE VERTQALRLV RKMITVNASL FPSSVTNSLI AVGNDGLQER DRMVRACIAI ICELALQNPE VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT RQYVRADVEL ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL LSVDPGRFQD SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI RNGLLEGLVE VITNSDDHIS VRATILLGEL LHMANTILPH SHSHHLHCLP TLMNMAASFD IPKEKRLRAS AALNCLKRFH EMKKRGPKPY SLHLDHIIQK AIATHQKRDQ YLRVQKDIFV LKDTEEALLI NLRDSQVLQH KENLEWNWNL IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG LLTTLSQHYF LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL TVSSLDYSRD GLARVILSKI LTAATDACRL YATKHLRVLL RANVEFFNNW GIELLVTQLH DKNKTISSEA LDILDEACED KANLHALIQM KPALSHLGDK GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHKEYNSKYV DLIEEQLNEA LTTYRKPVDG DNYVRRSNQR LQRPHVYLPI HLYGQLVHHK TGCHLLEVQN IITELCRNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP DILKLAKQCE VLSIRGTCVY VLGLIAKTKQ GCDILKCHNW DAVRHSRKHL WPVVPDDVEQ LCNELSSIPS TLSLNSESTS SRHNSESESV PSSMFILEDD RFGSSSTSTF FLDINEDTEP AYYDRSGPIK DKNSFPFFAS SKLVKNRILN SLTLPNKKHR SSSDPKGGKL SSESKTSNRR IRTLTEPSVD FNHSDDFTPT STAQKTLQLE TSFMGNKHIE DTGSTPSIGE NDLKFTKNFG TENHRENTSR ERLVVESSTS SHMKMRSQSF NTDTTTSGIS SMSSSPSRET VGIDATTMDT DCGSMSTVVS TKTVKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA QSLKAPSIAT IKSLADCNFS YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA LASPAKDVLF TDTITMKANS FESRLTPSRI DFKKKHVGGI RSLRPTITNN LFRFMKALSY ASLDKEDLLS PINQNTLQRS SSVRSMVSSA TYGGSDDYIG LALPVDINDI FQVKDIPYFQ TKNIPPHDDR GARAFAHDAG GLPSGTGGLV KNSFHLLRQQ MSLTEIMNSI HSDASLFLES TEDTGLQEHT DDNCLYCVCI EILGFQPSNQ LSAICSHSDF QDIPYSDWCE QTIHNPLEVV PSKFSGISGC SDGVSQEGSA SSTKSTELLL GVKTIPDDTP MCRILLRKEV LRLVINLSSS VSTKCHETGL LTIKEKYPQT FDDICLYSEV SHLLSHCTFR LPCRRFIQEL FQDVQFLQMH EEAEAVLATP PKQPIVDTSA ES //