ID F7GUW7_MACMU Unreviewed; 1710 AA. AC F7GUW7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 2. DT 12-SEP-2018, entry version 42. DE SubName: Full=RPTOR independent companion of MTOR complex 2 {ECO:0000313|Ensembl:ENSMMUP00000002157}; GN Name=RICTOR {ECO:0000313|Ensembl:ENSMMUP00000002157}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002157, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000002157, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002157} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JSUE03035793; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9544.ENSMMUP00000002157; -. DR Ensembl; ENSMMUT00000002281; ENSMMUP00000002157; ENSMMUG00000001611. DR eggNOG; KOG3694; Eukaryota. DR eggNOG; ENOG410XQ5Z; LUCA. DR GeneTree; ENSGT00390000002096; -. DR InParanoid; F7GUW7; -. DR OrthoDB; EOG091G01CV; -. DR TreeFam; TF343656; -. DR Proteomes; UP000006718; Chromosome 6. DR Bgee; ENSMMUG00000001611; Expressed in 14 organ(s), highest expression level in CD4-positive helper T cell. DR ExpressionAtlas; F7GUW7; baseline. DR GO; GO:0031932; C:TORC2 complex; IBA:GO_Central. DR GO; GO:0008047; F:enzyme activator activity; IBA:GO_Central. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl. DR GO; GO:0031532; P:actin cytoskeleton reorganization; IBA:GO_Central. DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Ensembl. DR GO; GO:0030010; P:establishment of cell polarity; IBA:GO_Central. DR GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IBA:GO_Central. DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IBA:GO_Central. DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:Ensembl. DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl. DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl. DR GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0033135; P:regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0042325; P:regulation of phosphorylation; IBA:GO_Central. DR GO; GO:0031929; P:TOR signaling; IEA:InterPro. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR028268; Pianissimo_fam. DR InterPro; IPR028267; Pianissimo_N. DR InterPro; IPR029453; Rictor_IV. DR InterPro; IPR029451; RICTOR_M. DR InterPro; IPR029259; RICTOR_phospho. DR InterPro; IPR029452; RICTOR_V. DR PANTHER; PTHR13298; PTHR13298; 1. DR Pfam; PF14663; RasGEF_N_2; 1. DR Pfam; PF14666; RICTOR_M; 1. DR Pfam; PF14664; RICTOR_N; 1. DR Pfam; PF14665; RICTOR_phospho; 1. DR Pfam; PF14668; RICTOR_V; 1. DR SMART; SM01307; RICTOR_M; 1. DR SMART; SM01308; RICTOR_N; 1. DR SMART; SM01309; RICTOR_phospho; 1. DR SMART; SM01310; RICTOR_V; 1. DR SUPFAM; SSF48371; SSF48371; 6. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 57 439 RICTOR_N. {ECO:0000259|SMART:SM01308}. FT DOMAIN 523 742 RICTOR_M. {ECO:0000259|SMART:SM01307}. FT DOMAIN 922 994 RICTOR_V. {ECO:0000259|SMART:SM01310}. SQ SEQUENCE 1710 AA; 192508 MW; B32FF71E9D367890 CRC64; MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG VSNMRKLGHL NNFTKLLCDI GHSEEKLGFN YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV LKLKVDYLIA RCIDIQQSNE VERTQALRLV RKMITVNASL FPSSVTNSLI AVGNDGLQER DRMVRACIAI ICELALQNPE VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT RQYVRADVEL ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL LSVDPGRFQD SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI RNGLLEGLVE VITNSDDHIS VRATILLGEL LHMANTILPH SHSHHLHCLP TLMNMAASFD IPKEKRLRAS AALNCLKRFH EMKKRGPKPY SLHLDHIIQK AIATHQKRDQ YLRVQKDIFV LKDTEEALLI NLRDSQVLQH KENLEWNWNL IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG LLTTLSQHYF LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL TVSSLDYSRD GLARVILSKI LTAATDACRL YATKHLRVLL RANVEFFNNW GIELLVTQLH DKNKTISSEA LDILDEACED KANLHALIQM KPALSHLGDK GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHKEYNSKYV DLIEEQLNEA LTTYRKPVDG DNYVRRSNQR CVPIHHKLFL TFLKNKYINI LLLMLFFLFL QNIITELCRN VRTPDLDKWE EIKKLKASLW ALGNIGSSNW GLNLLQEENV IPDILKLAKQ CEVLSIRGTC VYVLGLIAKT KQGCDILKCH NWDAVRHSRK HLWPVVPDDV EQLCNELSSI PSTLSLNSES TSSRHNSESE SVPSSMFILE DDRFGSSSTS TFFLDINEDT EPAYYDRSGP IKDKNSFPFF ASSKLVKNRI LNSLTLPNKK HRSSSDPKGG KLSSESKTSN RRIRTLTEPS VDFNHSDDFT PTSTAQKTLQ LETSFMGNKH IEDTGSTPSI GENDLKFTKN FGTENHRENT SRERLVVESS TSSHMKMRSQ SFNTDTTTSG ISSMSSSPSR ETVGIDATTM DTDCGSMSTV VSTKTVKTSH YLTPQSNHLS LSKSNSVSLV PPGSSHTLPR RAQSLKAPSI ATIKSLADCN FSYTSSRDAF GYATLKRLQQ QRMHPSLSHS EALASPAKDV LFTDTITMKA NSFESRLTPS RFMKALSYAS LDKEDLLSPI NQNTLQRSSS VRSMVSSATY GGSDDYIGLA LPVDINDIFQ VKDIPYFQTK NIPPHDDRGA RAFAHDAGGL PSGTGGLVKN SFHLLRQQMS LTEIMNSIHS DASLFLESTE DTGLQEHTDD NCLYCVCIEI LGFQPSNQLS AICSHSDFQD IPYSDWCEQT IHNPLEVVPS KFSGISGCSD GVSQEGSASS TKSTELLLGV KTIPDDTPMC RILLRKEVLR LVINLSSSVS TKCHETGLLT IKEKYPQTFD DICLYSEVSH LLSHCTFRLP CRRFIQELFQ DVQFLQMHEE AEAVLATPPK QPIVDTSAES //