ID F7GUW7_MACMU Unreviewed; 1676 AA. AC F7GUW7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 16-MAR-2016, entry version 28. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000002157}; DE Flags: Fragment; GN Name=RICTOR {ECO:0000313|Ensembl:ENSMMUP00000002157}; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002157, ECO:0000313|Proteomes:UP000006718}; RN [1] {ECO:0000313|Ensembl:ENSMMUP00000002157, ECO:0000313|Proteomes:UP000006718} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157, RC ECO:0000313|Proteomes:UP000006718}; RX PubMed=17431167; DOI=10.1126/science.1139247; RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., RA Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., RA Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E., RA Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., RA Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., RA Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., RA Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., RA Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., RA Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., RA Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., RA Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., RA Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., RA Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., RA Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., RA Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., RA Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., RA Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., RA Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., RA Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., RA Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., RA Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., RA Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., RA Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., RA Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., RA Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., RA Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., RA Zwieg A.S.; RT "Evolutionary and biomedical insights from the rhesus macaque RT genome."; RL Science 316:222-234(2007). RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002157} RP IDENTIFICATION. RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002157}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000002157}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 9544.ENSMMUP00000002157; -. DR Ensembl; ENSMMUT00000002281; ENSMMUP00000002157; ENSMMUG00000001611. DR eggNOG; KOG3694; Eukaryota. DR eggNOG; ENOG410XQ5Z; LUCA. DR GeneTree; ENSGT00390000002096; -. DR InParanoid; F7GUW7; -. DR OMA; RIDFKKK; -. DR OrthoDB; EOG7SBNMS; -. DR TreeFam; TF343656; -. DR Proteomes; UP000006718; Chromosome 6. DR ExpressionAtlas; F7GUW7; baseline. DR GO; GO:0031932; C:TORC2 complex; IBA:GO_Central. DR GO; GO:0008047; F:enzyme activator activity; IBA:GO_Central. DR GO; GO:0043022; F:ribosome binding; IEA:Ensembl. DR GO; GO:0031532; P:actin cytoskeleton reorganization; IBA:GO_Central. DR GO; GO:0009790; P:embryo development; IEA:Ensembl. DR GO; GO:0030010; P:establishment of cell polarity; IBA:GO_Central. DR GO; GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IBA:GO_Central. DR GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl. DR GO; GO:0043085; P:positive regulation of catalytic activity; IBA:GOC. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IBA:GO_Central. DR GO; GO:0032008; P:positive regulation of TOR signaling; IEA:Ensembl. DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl. DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl. DR GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl. DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl. DR GO; GO:0033135; P:regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0042325; P:regulation of phosphorylation; IBA:GO_Central. DR GO; GO:0031929; P:TOR signaling; IEA:InterPro. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR028268; Pianissimo_fam. DR InterPro; IPR028267; Pianissimo_N. DR InterPro; IPR029453; Rictor_IV. DR InterPro; IPR029451; RICTOR_M. DR InterPro; IPR029259; RICTOR_phospho. DR InterPro; IPR029452; RICTOR_V. DR PANTHER; PTHR13298; PTHR13298; 3. DR Pfam; PF14663; RasGEF_N_2; 1. DR Pfam; PF14666; RICTOR_M; 1. DR Pfam; PF14664; RICTOR_N; 1. DR Pfam; PF14665; RICTOR_phospho; 1. DR Pfam; PF14668; RICTOR_V; 1. DR SUPFAM; SSF48371; SSF48371; 7. DR PROSITE; PS51450; LRR; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000006718}; KW Reference proteome {ECO:0000313|Proteomes:UP000006718}. FT DOMAIN 26 407 RICTOR_N. {ECO:0000259|Pfam:PF14664}. FT DOMAIN 499 708 RICTOR_M. {ECO:0000259|Pfam:PF14666}. FT DOMAIN 715 820 RasGEF_N_2. {ECO:0000259|Pfam:PF14663}. FT DOMAIN 890 959 RICTOR_V. {ECO:0000259|Pfam:PF14668}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMMUP00000002157}. SQ SEQUENCE 1676 AA; 188707 MW; 648361132EEC4A2E CRC64; EPSDNLREIL QNVARLQGVS NMRKLGHLNN FTKLLCDIGH SEEKLGFNYE DIIICLRLAL LNEAKEVRAA GLRALRYLIQ DSSILQKVLK LKVDYLIARC IDIQQSNEVE RTQALRLVRK MITVNASLFP SSVTNSLIAV GNDGLQERDR MVRACIAIIC ELALQNPEVV ALRGGLNTIL KNVIDCQLSR INEALITTIL HLLNHPKTRQ YVRADVELER ILAPYTDFHY RHSPDTAEGQ LKEDREARFL ASKMGIIATF RSWAGIINLC KPGNSGIQSL IGVLCIPNME IRRGLLEVLY DIFRLPLPVV TEEFIEALLS VDPGRFQDSW RLSDGFVAAE AKTILPHRAR SRPDLMDNYL ALILSAFIRN GLLEGLVEVI TNSDDHISVR ATILLGELLH MANTILPHSH SHHLHCLPTL MNMAASFDIP KEKRLRASAA LNCLKRFHEM KKRGPKPYSL HLDHIIQKAI ATHQKRDQYL RVQKDIFVLK DTEEALLINL RDSQVLQHKE NLEWNWNLIG TILKWPNVNL RNYKDEQLHR FVRRLLYFYK PSSKLYANLD LDFAKAKQLT VVGCQFTEFL LESEEDGQGY LEDLVKDIVQ WLNASSGMKP ERSLQNNGLL TTLSQHYFLF IGTLSCHPHG VKMLEKCSVF QCLLNLCSLK NQDHLLKLTV SSLDYSRDGL ARVILSKILT AATDACRLYA TKHLRVLLRA NVEFFNNWGI ELLVTQLHDK NKTISSEALD ILDEACEDKA NLHALIQMKP ALSHLGDKGL LLLLRFLSIP KGFSYLNERG YVAKQLEKWH KEYNSKYVDL IEEQLNEALT TYRKPVDGDN YVRRSNQRLQ RPHVYLPIHL YGQLVHHKTG CHLLEVQNII TELCRNVRTP DLDKWEEIKK LKASLWALVI NTSVRSLQFL DFSENVIPDI LKLAKQCEVL SIRGTCVYVL GLIAKTKQGC DILKCHNWDA VRHSRKHLWP VVPDDVEQLC NELSSIPSTL SLNSESTSSR HNSESESVPS SMFILEDDRF GSSSTSTFFL DINEDTEPAY YDRSGPIKDK NSFPFFASSK LVKNRILNSL TLPNKKHRSS SDPKGGKLSS ESKTSNRRIR TLTEPSVDFN HSDDFTPTST AQKTLQLETS FMGNKHIEDT GSTPSIGEND LKFTKNFGTE NHRENTSRER LVVESSTSSH MKMRSQSFNT DTTTSGISSM SSSPSRETVG IDATTMDTDC GSMSTVVSTK TVKTSHYLTP QSNHLSLSKS NSVSLVPPGS SHTLPRRAQS LKAPSIATIK SLADCNFSYT SSRDAFGYAT LKRLQQQRMH PSLSHSEALA SPAKDVLFTD TITMKANSFE SRLTPSRFMK ALSYASLDKE DLLSPINQNT LQRSSSVRSM VSSATYGGSD DYIGLALPVD INDIFQVKDI PYFQTKNIPP HDDRGARAFA HDAGGLPSGT GGLVKNSFHL LRQQMSLTEI MNSIHSDASL FLESTEDTGL QEHTDDNCLY CVCIEILGFQ PSNQLSAICS HSDFQDIPYS DWCEQTIHNP LEVVPSKFSG ISGCSDGVSQ EGSASSTKST ELLLGVKTIP DDTPMCRILL RKEVLRLVIN LSSSVSTKCH ETGLLTIKEK YPQTFDDICL YSEVSHLLSH CTFRLPCRRF IQELFQDVQF LQMHEEAEAV LATPPKQPIV DTSAES //