ID F7F9F5_RAT Unreviewed; 247 AA. AC F7F9F5; DT 28-JUN-2023, integrated into UniProtKB/TrEMBL. DT 28-JUN-2023, sequence version 1. DT 29-MAY-2024, entry version 6. DE SubName: Full=Monocyte to macrophage differentiation-associated 2 {ECO:0000313|EMBL:AAI61816.1}; DE SubName: Full=RCG42628, isoform CRA_b {ECO:0000313|EMBL:EDL89707.1}; GN Name=Mmd2 {ECO:0000313|EMBL:AAI61816.1, ECO:0000313|RGD:1306506}; GN ORFNames=rCG_42628 {ECO:0000313|EMBL:EDL89707.1}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI61816.1}; RN [1] {ECO:0000313|EMBL:AAI61816.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI61816.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] {ECO:0000313|EMBL:EDL89707.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL89707.1}; RX PubMed=15632090; DOI=10.1101/gr.2889405; RA Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., RA Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., RA Istrail S., Li P., Sutton G.; RT "Gene and alternative splicing annotation with AIR."; RL Genome Res. 15:54-66(2005). RN [3] {ECO:0000313|EMBL:EDL89707.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BN {ECO:0000313|EMBL:EDL89707.1}; RA Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., RA Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., RA Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F., RA Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., RA Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the ADIPOR family. CC {ECO:0000256|ARBA:ARBA00007018}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC161816; AAI61816.1; -; mRNA. DR EMBL; CH474012; EDL89707.1; -; Genomic_DNA. DR RefSeq; NP_001032294.1; NM_001037217.1. DR GeneID; 304301; -. DR KEGG; rno:304301; -. DR AGR; RGD:1306506; -. DR CTD; 221938; -. DR RGD; 1306506; Mmd2. DR eggNOG; KOG4243; Eukaryota. DR HOGENOM; CLU_051078_0_0_1; -. DR OrthoDB; 2903256at2759; -. DR TreeFam; TF313370; -. DR Proteomes; UP000234681; Chromosome 12. DR GO; GO:0000139; C:Golgi membrane; ISO:RGD. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0140911; F:pore-forming activity; IEA:InterPro. DR GO; GO:0004672; F:protein kinase activity; ISO:RGD. DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD. DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:RGD. DR GO; GO:0032880; P:regulation of protein localization; ISO:RGD. DR InterPro; IPR004254; AdipoR/HlyIII-related. DR InterPro; IPR005744; Hy-lIII. DR NCBIfam; TIGR01065; hlyIII; 1. DR PANTHER; PTHR20855; ADIPOR/PROGESTIN RECEPTOR-RELATED; 1. DR PANTHER; PTHR20855:SF107; MONOCYTE TO MACROPHAGE DIFFERENTIATION FACTOR 2; 1. DR Pfam; PF03006; HlyIII; 1. PE 2: Evidence at transcript level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR604254-1}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PIRSR:PIRSR604254-1}. FT TRANSMEM 71..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 110..126 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 138..154 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 161..180 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 186..203 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 215..235 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT BINDING 88 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1" FT BINDING 213 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1" FT BINDING 217 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1" SQ SEQUENCE 247 AA; 28938 MW; 4BFF2564F85A2A1E CRC64; MFTLARLLDF QKTKYARFMN DRVPAHKRYR PTEYEHAANC ATHAFWIIPS ILGSSNLYFL SDDDWETISA WIYGLGLCGL FVVSTIFHTV SWKKSHLRMV EHCLHMIDRM VIYFFIAASY APWLNLRELG PWASHMRWLV WIMASIGTVY VFFFHERYKL VELLCYVVMG FFPALVILSM PNTEGIWELM TGGAFYCLGM VFFKSDGRIP FAHAIWHLFV AFGAGTHYYA IWRYLYLPST LQTKVSK //