ID F7E9U1_MONDO Unreviewed; 564 AA. AC F7E9U1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-MAR-2018, entry version 53. DE SubName: Full=Frizzled class receptor 1 {ECO:0000313|Ensembl:ENSMODP00000013160}; GN Name=FZD1 {ECO:0000313|Ensembl:ENSMODP00000013160}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013160, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000013160, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., RA Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., RA Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., RA Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., RA Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., RA Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., RA Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., RA Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., RA Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., RA Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., RA Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., RA Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., RA Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., RA Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., RA Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., RA Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., RA Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., RA Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., RA Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., RA Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., RA Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., RA Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., RA Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., RA Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., RA Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., RA Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., RA Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., RA Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., RA Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., RA Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., RA Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., RA Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., RA Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., RA Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., RA Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., RA Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., RA Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., RA Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in RT non-coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000013160} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo CC family. {ECO:0000256|SAAS:SAAS00874568}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 13616.ENSMODP00000013160; -. DR Ensembl; ENSMODT00000013402; ENSMODP00000013160; ENSMODG00000010505. DR eggNOG; KOG3577; Eukaryota. DR eggNOG; ENOG410XRC8; LUCA. DR GeneTree; ENSGT00760000118864; -. DR InParanoid; F7E9U1; -. DR OMA; KFPVHGA; -. DR OrthoDB; EOG091G0N5M; -. DR TreeFam; TF317907; -. DR Proteomes; UP000002280; Chromosome 8. DR Bgee; ENSMODG00000010505; -. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central. DR GO; GO:0005109; F:frizzled binding; IEA:Ensembl. DR GO; GO:0004930; F:G-protein coupled receptor activity; IBA:GO_Central. DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl. DR GO; GO:0042813; F:Wnt-activated receptor activity; IBA:GO_Central. DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central. DR GO; GO:0035425; P:autocrine signaling; IEA:Ensembl. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central. DR GO; GO:0044338; P:canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation; IEA:Ensembl. DR GO; GO:0044339; P:canonical Wnt signaling pathway involved in osteoblast differentiation; IEA:Ensembl. DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl. DR GO; GO:0060022; P:hard palate development; IEA:Ensembl. DR GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl. DR GO; GO:0003150; P:muscular septum morphogenesis; IEA:Ensembl. DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl. DR GO; GO:0035414; P:negative regulation of catenin import into nucleus; IEA:Ensembl. DR GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IEA:Ensembl. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl. DR GO; GO:0035567; P:non-canonical Wnt signaling pathway; IBA:GO_Central. DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl. DR GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Ensembl. DR GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; IEA:Ensembl. DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl. DR GO; GO:0042493; P:response to drug; IEA:Ensembl. DR Gene3D; 1.10.2000.10; -; 1. DR InterPro; IPR015526; Frizzled/SFRP. DR InterPro; IPR000539; Frizzled/Smoothened_TM. DR InterPro; IPR020067; Frizzled_dom. DR InterPro; IPR036790; Frizzled_dom_sf. DR InterPro; IPR026548; FZD1. DR InterPro; IPR017981; GPCR_2-like. DR PANTHER; PTHR11309; PTHR11309; 1. DR PANTHER; PTHR11309:SF81; PTHR11309:SF81; 1. DR Pfam; PF01534; Frizzled; 1. DR Pfam; PF01392; Fz; 1. DR PRINTS; PR00489; FRIZZLED. DR SMART; SM00063; FRI; 1. DR SMART; SM01330; Frizzled; 1. DR SUPFAM; SSF63501; SSF63501; 1. DR PROSITE; PS50038; FZ; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000002280}; KW Developmental protein {ECO:0000256|SAAS:SAAS00022660}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00090, KW ECO:0000256|SAAS:SAAS00978052}; KW Membrane {ECO:0000256|SAAS:SAAS00874221, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00874335}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Transmembrane {ECO:0000256|SAAS:SAAS00874792, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00874766, KW ECO:0000256|SAM:Phobius}; KW Wnt signaling pathway {ECO:0000256|SAAS:SAAS00022642}. FT TRANSMEM 239 260 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 272 292 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 321 346 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 366 385 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 405 431 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 452 475 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 517 539 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 21 140 FZ. {ECO:0000259|PROSITE:PS50038}. FT DOMAIN 234 546 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. FT DISULFID 26 87 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 34 80 {ECO:0000256|PROSITE-ProRule:PRU00090}. FT DISULFID 101 125 {ECO:0000256|PROSITE-ProRule:PRU00090}. SQ SEQUENCE 564 AA; 62486 MW; 2C3343A20F29ADD3 CRC64; GQQPQPQPQQ QYHGERGISI PDHGYCQPIS IPLCTDIAYN QTIMPNLLGH TNQEDAGLEV HQFYPLVKVQ CSAELKFFLC SMYAPVCTVL EQALPPCRSL CERARQGCEA LMNKFGFQWP DTLRCEKFPV HGAGELCVGQ NTSDKGTPTP SLLPEFWTSN PQHGSGAGAG GGRGGGGIGS GGASSSERGK FSCPRALKVP SYLNYHFLGE KDCGAPCEPT KVYGLMYFGP EELRFSRTWI GIWSVLCCAS TLFTVLTYLV DMRRFSYPER PIIFLSGCYT AVAVAYIAGF LLEDRVVCNE KFAEDGARTV AQGTKKEGCT ILFMMLYFFS MASSIWWVIL SLTWFLAAGM KWGHEAIEAN SQYFHLAAWA VPAIKTITIL ALGQVDGDIL SGVCFVGLNN VDALRGFVLA PLFVYLFIGT SFLLAGFVSL FRIRTIMKHD GTKTEKLEKL MVRIGVFSVL YTVPATIVIA CYFYEQAFRE QWERSWVAQS CKSYAIPCPH HQGGGGGPPH PPMSPDFTVF MIKYLMTLIV GITSGFWIWS GKTLNSWRKF YTRLTNSKQG ETTV //