ID F7D286_XENTR Unreviewed; 665 AA. AC F7D286; Q5HZT3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 4. DT 02-OCT-2024, entry version 62. DE RecName: Full=Transmembrane protein 255A {ECO:0000256|ARBA:ARBA00039451}; DE AltName: Full=Protein FAM70A {ECO:0000256|ARBA:ARBA00041817}; GN Name=lamp2 {ECO:0000313|Ensembl:ENSXETP00000009717}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000009717}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000009717} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000009717}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J., RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., RA Khokha M.K., Richardson P.M., Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000009717} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I CC membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane CC protein {ECO:0000256|PROSITE-ProRule:PRU00740}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000256|PROSITE- CC ProRule:PRU00740}. CC -!- SIMILARITY: Belongs to the TMEM255 family. CC {ECO:0000256|ARBA:ARBA00007903}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00740}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; F7D286; -. DR STRING; 8364.ENSXETP00000009717; -. DR DNASU; 497005; -. DR Ensembl; ENSXETT00000009717; ENSXETP00000009717; ENSXETG00000004476. DR Xenbase; XB-GENE-962456; lamp2. DR eggNOG; ENOG502QVX8; Eukaryota. DR HOGENOM; CLU_068698_1_0_1; -. DR InParanoid; F7D286; -. DR OrthoDB; 5395027at2759; -. DR PhylomeDB; F7D286; -. DR TreeFam; TF331034; -. DR Bgee; ENSXETG00000004476; Expressed in skeletal muscle tissue and 15 other cell types or tissues. DR ExpressionAtlas; F7D286; baseline. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR Gene3D; 2.40.160.110; -; 2. DR InterPro; IPR048528; Lamp2-like_luminal. DR InterPro; IPR018134; LAMP_CS. DR InterPro; IPR002000; Lysosome-assoc_membr_glycop. DR InterPro; IPR028014; TMEM255. DR PANTHER; PTHR33721; -; 1. DR PANTHER; PTHR33721:SF1; TRANSMEMBRANE PROTEIN 255A; 1. DR Pfam; PF14967; FAM70; 1. DR Pfam; PF01299; Lamp2-like_luminal; 2. DR PRINTS; PR00336; LYSASSOCTDMP. DR PROSITE; PS00310; LAMP_1; 1. DR PROSITE; PS51407; LAMP_3; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Lysosome {ECO:0000256|PROSITE-ProRule:PRU00740}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00740}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00740}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..665 FT /note="Transmembrane protein 255A" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5030169975" FT TRANSMEM 373..393 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 405..425 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 431..456 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 539..564 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 30..171 FT /note="Lysosome-associated membrane glycoprotein 2-like FT luminal" FT /evidence="ECO:0000259|Pfam:PF01299" FT DOMAIN 214..356 FT /note="Lysosome-associated membrane glycoprotein 2-like FT luminal" FT /evidence="ECO:0000259|Pfam:PF01299" FT REGION 180..217 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 623..643 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 186..217 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 623..640 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 665 AA; 72025 MW; A3538AE8F914DF34 CRC64; MERCACPAAL LLLSLVLMGA MAFDVEIKDD KNATCIYAKL SVNVTVQYET NTSSTKNVTF SVPSEVTTNG SSCGSNGKAP ILVINFGNGH SWSLNFTRND SMYSGGALIF TYNTNDSTLF PDALKEGLIS STAAFLGPIP LNSTYKCISS EVVVSENVTQ IISDVKLEAF MQNGTLGKEV SCDADKPSPT PTTNPSTTAS TTTPTPTSKP LDNPTTGNYS VSDVNGTCLL ASMGLQINTS LLSEGKNIWT AFNIDPTAMS KNGTCSNQTG TLILTDNSTV IEFTLALKNK NHFYLKEVNV ALINGSASST RQNQNLSAWE ASVGSSYMCH KEQQIKVSED LVINSFDVRV QLFGVKNETF ATGSFNKRRR NSIFVTVTLL IVSSLIFTLG LAATTRTENV TVGGYYPGVI LGFGSILGII GSNLIENKRQ MLVASIVFIS FGVIAAFCCA IVDGVFAARH LDLRPLYAGK CRYFSTTHND HTTEVTCQQP MRSPCALKIR SNTCYCCDLY NCGRIGNSGL YYEYIDVKSC QDVVHLYHLL WSVTILNIVG LFLGIITAAV LGGFKDMNPA LPTISCIAET PRPTVQYNTR PPVPSYNTYY HSTPHLPPYT AYDLQHSSVF PASTPSGLSD DPNAQASSFM WPANAPPRYS PPYFPPDEKP PPYTP //