ID   F7D286_XENTR            Unreviewed;       665 AA.
AC   F7D286; Q5HZT3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 4.
DT   24-JUL-2024, entry version 61.
DE   RecName: Full=Transmembrane protein 255A {ECO:0000256|ARBA:ARBA00039451};
DE   AltName: Full=Protein FAM70A {ECO:0000256|ARBA:ARBA00041817};
GN   Name=lamp2 {ECO:0000313|Ensembl:ENSXETP00000009717};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000009717};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000009717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000009717};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000009717}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I
CC       membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane
CC       protein {ECO:0000256|PROSITE-ProRule:PRU00740}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00740}.
CC   -!- SIMILARITY: Belongs to the TMEM255 family.
CC       {ECO:0000256|ARBA:ARBA00007903}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00740}.
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DR   AlphaFoldDB; F7D286; -.
DR   STRING; 8364.ENSXETP00000009717; -.
DR   DNASU; 497005; -.
DR   Ensembl; ENSXETT00000009717; ENSXETP00000009717; ENSXETG00000004476.
DR   Xenbase; XB-GENE-962456; lamp2.
DR   eggNOG; ENOG502QVX8; Eukaryota.
DR   HOGENOM; CLU_068698_1_0_1; -.
DR   InParanoid; F7D286; -.
DR   OrthoDB; 5395027at2759; -.
DR   PhylomeDB; F7D286; -.
DR   TreeFam; TF331034; -.
DR   Bgee; ENSXETG00000004476; Expressed in skeletal muscle tissue and 15 other cell types or tissues.
DR   ExpressionAtlas; F7D286; baseline.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.160.110; -; 2.
DR   InterPro; IPR048528; Lamp2-like_luminal.
DR   InterPro; IPR018134; LAMP_CS.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   InterPro; IPR028014; TMEM255.
DR   PANTHER; PTHR33721; -; 1.
DR   PANTHER; PTHR33721:SF1; TRANSMEMBRANE PROTEIN 255A; 1.
DR   Pfam; PF14967; FAM70; 1.
DR   Pfam; PF01299; Lamp; 2.
DR   PRINTS; PR00336; LYSASSOCTDMP.
DR   PROSITE; PS00310; LAMP_1; 1.
DR   PROSITE; PS51407; LAMP_3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lysosome {ECO:0000256|PROSITE-ProRule:PRU00740};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00740};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00740};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..665
FT                   /note="Transmembrane protein 255A"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030169975"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        431..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        539..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          30..171
FT                   /note="Lysosome-associated membrane glycoprotein 2-like
FT                   luminal"
FT                   /evidence="ECO:0000259|Pfam:PF01299"
FT   DOMAIN          214..356
FT                   /note="Lysosome-associated membrane glycoprotein 2-like
FT                   luminal"
FT                   /evidence="ECO:0000259|Pfam:PF01299"
FT   REGION          180..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          623..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        623..640
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  72025 MW;  A3538AE8F914DF34 CRC64;
     MERCACPAAL LLLSLVLMGA MAFDVEIKDD KNATCIYAKL SVNVTVQYET NTSSTKNVTF
     SVPSEVTTNG SSCGSNGKAP ILVINFGNGH SWSLNFTRND SMYSGGALIF TYNTNDSTLF
     PDALKEGLIS STAAFLGPIP LNSTYKCISS EVVVSENVTQ IISDVKLEAF MQNGTLGKEV
     SCDADKPSPT PTTNPSTTAS TTTPTPTSKP LDNPTTGNYS VSDVNGTCLL ASMGLQINTS
     LLSEGKNIWT AFNIDPTAMS KNGTCSNQTG TLILTDNSTV IEFTLALKNK NHFYLKEVNV
     ALINGSASST RQNQNLSAWE ASVGSSYMCH KEQQIKVSED LVINSFDVRV QLFGVKNETF
     ATGSFNKRRR NSIFVTVTLL IVSSLIFTLG LAATTRTENV TVGGYYPGVI LGFGSILGII
     GSNLIENKRQ MLVASIVFIS FGVIAAFCCA IVDGVFAARH LDLRPLYAGK CRYFSTTHND
     HTTEVTCQQP MRSPCALKIR SNTCYCCDLY NCGRIGNSGL YYEYIDVKSC QDVVHLYHLL
     WSVTILNIVG LFLGIITAAV LGGFKDMNPA LPTISCIAET PRPTVQYNTR PPVPSYNTYY
     HSTPHLPPYT AYDLQHSSVF PASTPSGLSD DPNAQASSFM WPANAPPRYS PPYFPPDEKP
     PPYTP
//