ID F7D286_XENTR Unreviewed; 665 AA. AC F7D286; Q5HZT3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 02-JUN-2021, sequence version 4. DT 22-FEB-2023, entry version 53. DE SubName: Full=Lysosomal-associated membrane protein 2 {ECO:0000313|Ensembl:ENSXETP00000009717}; GN Name=tmem255a {ECO:0000313|Xenbase:XB-GENE-941241}; GN Synonyms=lamp2 {ECO:0000313|Ensembl:ENSXETP00000009717}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000009717}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000009717} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000009717}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J., RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., RA Khokha M.K., Richardson P.M., Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000009717} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane CC protein {ECO:0000256|PROSITE-ProRule:PRU00740}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Membrane CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000256|ARBA:ARBA00009644, CC ECO:0000256|PROSITE-ProRule:PRU00740}. CC -!- SIMILARITY: Belongs to the TMEM255 family. CC {ECO:0000256|ARBA:ARBA00007903}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00740}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001011501.1; NM_001011501.2. DR AlphaFoldDB; F7D286; -. DR STRING; 8364.ENSXETP00000009717; -. DR PaxDb; F7D286; -. DR DNASU; 497005; -. DR Ensembl; ENSXETT00000009717; ENSXETP00000009717; ENSXETG00000004476. DR GeneID; 497005; -. DR KEGG; xtr:497005; -. DR CTD; 55026; -. DR Xenbase; XB-GENE-962456; lamp2. DR Xenbase; XB-GENE-941241; tmem255a. DR eggNOG; ENOG502QVX8; Eukaryota. DR HOGENOM; CLU_068698_1_0_1; -. DR InParanoid; F7D286; -. DR OrthoDB; 5395027at2759; -. DR PhylomeDB; F7D286; -. DR TreeFam; TF331034; -. DR Bgee; ENSXETG00000004476; Expressed in skeletal muscle tissue and 15 other tissues. DR ExpressionAtlas; F7D286; baseline. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005764; C:lysosome; IEA:UniProt. DR Gene3D; 2.40.160.110; -; 2. DR InterPro; IPR018134; LAMP_CS. DR InterPro; IPR002000; Lysosome-assoc_membr_glycop. DR InterPro; IPR028014; TMEM255. DR PANTHER; PTHR33721; -; 1. DR PANTHER; PTHR33721:SF1; TRANSMEMBRANE PROTEIN 255A; 1. DR Pfam; PF14967; FAM70; 1. DR Pfam; PF01299; Lamp; 1. DR PRINTS; PR00336; LYSASSOCTDMP. DR PROSITE; PS00310; LAMP_1; 1. DR PROSITE; PS51407; LAMP_3; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Lysosome {ECO:0000256|PROSITE-ProRule:PRU00740}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU00740}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU00740}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..665 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5030169975" FT TRANSMEM 373..393 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 405..425 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 431..456 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 539..564 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 180..217 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 623..643 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 186..217 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 623..640 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 665 AA; 72025 MW; A3538AE8F914DF34 CRC64; MERCACPAAL LLLSLVLMGA MAFDVEIKDD KNATCIYAKL SVNVTVQYET NTSSTKNVTF SVPSEVTTNG SSCGSNGKAP ILVINFGNGH SWSLNFTRND SMYSGGALIF TYNTNDSTLF PDALKEGLIS STAAFLGPIP LNSTYKCISS EVVVSENVTQ IISDVKLEAF MQNGTLGKEV SCDADKPSPT PTTNPSTTAS TTTPTPTSKP LDNPTTGNYS VSDVNGTCLL ASMGLQINTS LLSEGKNIWT AFNIDPTAMS KNGTCSNQTG TLILTDNSTV IEFTLALKNK NHFYLKEVNV ALINGSASST RQNQNLSAWE ASVGSSYMCH KEQQIKVSED LVINSFDVRV QLFGVKNETF ATGSFNKRRR NSIFVTVTLL IVSSLIFTLG LAATTRTENV TVGGYYPGVI LGFGSILGII GSNLIENKRQ MLVASIVFIS FGVIAAFCCA IVDGVFAARH LDLRPLYAGK CRYFSTTHND HTTEVTCQQP MRSPCALKIR SNTCYCCDLY NCGRIGNSGL YYEYIDVKSC QDVVHLYHLL WSVTILNIVG LFLGIITAAV LGGFKDMNPA LPTISCIAET PRPTVQYNTR PPVPSYNTYY HSTPHLPPYT AYDLQHSSVF PASTPSGLSD DPNAQASSFM WPANAPPRYS PPYFPPDEKP PPYTP //