ID F7CR09_HORSE Unreviewed; 648 AA. AC F7CR09; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 10-APR-2019, sequence version 2. DT 05-JUN-2019, entry version 51. DE SubName: Full=HNF1 homeobox A {ECO:0000313|Ensembl:ENSECAP00000017518}; GN Name=HNF1A {ECO:0000313|Ensembl:ENSECAP00000017518, GN ECO:0000313|VGNC:VGNC:50939}; OS Equus caballus (Horse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017518, ECO:0000313|Proteomes:UP000002281}; RN [1] {ECO:0000313|Ensembl:ENSECAP00000017518, ECO:0000313|Proteomes:UP000002281} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017518, RC ECO:0000313|Proteomes:UP000002281}; RX PubMed=19892987; DOI=10.1126/science.1178158; RG Broad Institute Genome Sequencing Platform; RG Broad Institute Whole Genome Assembly Team; RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., RA Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., RA Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L., RA Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., RA Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., RA Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., RA Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., RA Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., RA Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., RA White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.; RT "Genome sequence, comparative analysis, and population genetics of the RT domestic horse."; RL Science 326:865-867(2009). RN [2] {ECO:0000313|Ensembl:ENSECAP00000017518} RP IDENTIFICATION. RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017518}; RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE- CC ProRule:PRU00108}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PaxDb; F7CR09; -. DR Ensembl; ENSECAT00000021278; ENSECAP00000017518; ENSECAG00000019954. DR VGNC; VGNC:50939; HNF1A. DR eggNOG; ENOG410IFA0; Eukaryota. DR eggNOG; ENOG410ZZZ0; LUCA. DR GeneTree; ENSGT00940000153818; -. DR InParanoid; F7CR09; -. DR OMA; PATTIHI; -. DR TreeFam; TF320327; -. DR Proteomes; UP000002281; Chromosome 8. DR Bgee; ENSECAG00000019954; Expressed in 2 organ(s), highest expression level in liver. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl. DR GO; GO:0045120; C:pronucleus; IEA:Ensembl. DR GO; GO:0005667; C:transcription factor complex; IEA:Ensembl. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl. DR GO; GO:0015721; P:bile acid and bile salt transport; IEA:Ensembl. DR GO; GO:0006699; P:bile acid biosynthetic process; IEA:Ensembl. DR GO; GO:0001824; P:blastocyst development; IEA:Ensembl. DR GO; GO:0045453; P:bone resorption; IEA:Ensembl. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl. DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl. DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl. DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:Ensembl. DR GO; GO:0015908; P:fatty acid transport; IEA:Ensembl. DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl. DR GO; GO:0046323; P:glucose import; IEA:Ensembl. DR GO; GO:0006783; P:heme biosynthetic process; IEA:Ensembl. DR GO; GO:0016573; P:histone acetylation; IEA:Ensembl. DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl. DR GO; GO:0001889; P:liver development; IEA:Ensembl. DR GO; GO:0048341; P:paraxial mesoderm formation; IEA:Ensembl. DR GO; GO:0001890; P:placenta development; IEA:Ensembl. DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central. DR GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0035623; P:renal glucose absorption; IEA:Ensembl. DR GO; GO:0009749; P:response to glucose; IEA:Ensembl. DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl. DR GO; GO:0043691; P:reverse cholesterol transport; IEA:Ensembl. DR GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR039066; HNF-1. DR InterPro; IPR006899; HNF-1_N. DR InterPro; IPR023219; HNF1_dimer_N_dom_sf. DR InterPro; IPR006898; HNF1a_C. DR InterPro; IPR006897; HNF1b_C. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf. DR PANTHER; PTHR11568; PTHR11568; 1. DR Pfam; PF04814; HNF-1_N; 1. DR Pfam; PF04813; HNF-1A_C; 1. DR Pfam; PF04812; HNF-1B_C; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF100957; SSF100957; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR SUPFAM; SSF47413; SSF47413; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000002281}; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108}; KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}; KW Reference proteome {ECO:0000313|Proteomes:UP000002281}. FT DOMAIN 197 278 Homeobox. {ECO:0000259|PROSITE:PS50071}. FT DNA_BIND 199 279 Homeobox. {ECO:0000256|PROSITE-ProRule: FT PRU00108}. FT REGION 40 83 Disordered. {ECO:0000256|MobiDB-lite: FT F7CR09}. FT REGION 183 205 Disordered. {ECO:0000256|MobiDB-lite: FT F7CR09}. FT REGION 283 345 Disordered. {ECO:0000256|MobiDB-lite: FT F7CR09}. FT COMPBIAS 288 312 Pro-rich. {ECO:0000256|MobiDB-lite: FT F7CR09}. FT COMPBIAS 329 345 Polar. {ECO:0000256|MobiDB-lite:F7CR09}. SQ SEQUENCE 648 AA; 69446 MW; 080EA7340533BB16 CRC64; MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLLAG DGPLDKGESC GGGRGELAEL PNGLGETRGS EDETDDDGED FTPPILKELE NLSPEEAAHQ KAVVETLLQE DPWRVAKMVK SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE ALVEECNRAE CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYSGPP PGPGPGPALP AHSSPGLPPP ALSPSKVHGV RYGQPATSEG AEVPSSSGGP LVTVSAPLHQ VSPTGLEPSH SLLSTEAKLV SATGGPLPPV STLTALHSLE QTSPGLNQQP QNLIMASLPG VMAIGPGEPA SLGPTFTNTG ASTLVIGLAS TQAQSVPVIN SMGSSLTTLQ PVQFSQPLHP SYQQPLMPPV QSHVAQSPFM ATMAQLQSPH ALYSHKPEVA QYTHTGLLPQ TMLITDTTNL SALASLTPTK QVRPRPHSRR LRRLLFSQVF TTDTEASSES GLHPPVSQAT TIHIPSQDSA GIQHLQPAHR LSTSPTVSSS SLVLYQSSDS SNGHSHLLPS NHSVIETFIS TQMASSSQ //