ID F7CJ77_MOUSE Unreviewed; 1579 AA. AC F7CJ77; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 18-SEP-2019, entry version 4. DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0000313|Ensembl:ENSMUSP00000097164}; GN Name=Trpm3 {ECO:0000313|Ensembl:ENSMUSP00000097164, GN ECO:0000313|MGI:MGI:2443101}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097164, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000097164, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097164, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000097164} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097164}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC123066; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC124513; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132389; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132454; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC140411; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC164427; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006527040.1; XM_006526977.2. DR Ensembl; ENSMUST00000099569; ENSMUSP00000097164; ENSMUSG00000052387. DR GeneID; 226025; -. DR KEGG; mmu:226025; -. DR CTD; 80036; -. DR MGI; MGI:2443101; Trpm3. DR GeneTree; ENSGT00940000157366; -. DR HOGENOM; HOG000230920; -. DR KO; K04978; -. DR OrthoDB; 738147at2759; -. DR TreeFam; TF314204; -. DR ChiTaRS; Trpm3; mouse. DR Proteomes; UP000000589; Chromosome 19. DR Bgee; ENSMUSG00000052387; Expressed in 88 organ(s), highest expression level in pigmented layer of retina. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro. DR GO; GO:0005261; F:cation channel activity; ISO:MGI. DR GO; GO:0006812; P:cation transport; ISO:MGI. DR GO; GO:0016048; P:detection of temperature stimulus; IEA:InterPro. DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro. DR GO; GO:0050951; P:sensory perception of temperature stimulus; IEA:InterPro. DR Gene3D; 1.20.5.1010; -; 1. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR029583; TRPM3. DR InterPro; IPR041491; TRPM_SLOG. DR InterPro; IPR032415; TRPM_tetra. DR InterPro; IPR037162; TRPM_tetra_sf. DR PANTHER; PTHR13800:SF7; PTHR13800:SF7; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF18139; LSDAT_euk; 1. DR Pfam; PF16519; TRPM_tetra; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F7CJ77, KW ECO:0000213|PeptideAtlas:F7CJ77}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 745 764 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 812 830 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 842 860 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 881 901 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 959 984 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 290 LSDAT_euk. {ECO:0000259|Pfam:PF18139}. FT DOMAIN 751 993 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT DOMAIN 1087 1142 TRPM_tetra. {ECO:0000259|Pfam:PF16519}. FT REGION 676 698 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1307 1329 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 1457 1579 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COILED 1090 1110 {ECO:0000256|SAM:Coils}. FT COILED 1128 1148 {ECO:0000256|SAM:Coils}. FT COMPBIAS 678 698 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 1307 1321 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 1457 1475 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 1478 1505 Polar. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 1579 AA; 180236 MW; 98C0C6DFC8166579 CRC64; MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL IGRDVVRPYQ TMSNPMSKLT VLNSMHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRCLPFFSLD SRLFYSFWGS CQLDPIGIGQ GVPVVALIVE GGPNVISIVL EYLRDTPPVP VVVCDGSGRA SDILAFGHKY SEEGGLINES LRDQLLVTIQ KTFTYTRTQA QHLFIILMEC MKKKELITVF RMGSEGHQDI DLAILTALLK GANASAPDQL SLALAWNRVD IARSQIFIYG QQWPVGSLEQ AMLDALVLDR VDFVKLLIEN GVSMHRFLTI SRLEELYNTR HGPSNTLYHL VRDVKKGNLP PDYRISLIDI GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG PKRPKALKLL GMEDDIPLRR GRKTTKKREE EVDIDLDDPE INHFPFPFHE LMVWAVLMKR QKMALFFWQH GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR DFGQLAVELL DQSYKQDEQL AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT DMWMGRLRMR KNSGLKVILG ILLPPSILSL EFKNKDDMPY MTQAQEIHLQ EKEPEEPEKP TKEKDEEDME LTAMLGRSNG ESSRKKDEEE VQSRHRLIPV GRKIYEFYNA PIVKFWFYTL AYIGYLMLFN YIVLVKMERW PSTQEWIVIS YIFTLGIEKM REILMSEPGK LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL RLQDQPFRSD GRVIYCVNII YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM MYFVIIMLVV LMSFGVARQA ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA DQIDPPCGQN ETREDGKTIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHVCCRWRKH ESDQDERDYG LKLFITDDEL KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT VDIRLAQLED LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT FKLQESIDPA GEETISPTSP TLMPRMRSHS FYSVNVKDKG GIEKLESIFK ERSLSLHRAT SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIEPLD NSMNILGLGE PSFSALAPST TPSSSAYATL APTDRPPSRS IDFEDLTSMD TRSFSSDYTH LPECQNPWDT DPPTYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT DCIDTRCVNA PQAIADRATF PGGLGDKVED LSCCHPEREA ELSHPSSDSE ENEARGQRAA NPISSQEAEN ADRTLSNNIT VPKIERANSY SAEEPNVPYA HTRKSFSISD KLDRQRNTAS LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FHSFESKHN //