ID F7CJ77_MOUSE Unreviewed; 1579 AA. AC F7CJ77; DT 05-JUN-2019, integrated into UniProtKB/TrEMBL. DT 05-JUN-2019, sequence version 1. DT 27-MAR-2024, entry version 27. DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 3 {ECO:0000313|Ensembl:ENSMUSP00000097164.4}; GN Name=Trpm3 {ECO:0000313|Ensembl:ENSMUSP00000097164.4, GN ECO:0000313|MGI:MGI:2443101}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097164.4, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000097164.4, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097164.4, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000097164.4} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097164.4}; RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_006527040.1; XM_006526977.2. DR SMR; F7CJ77; -. DR Antibodypedia; 12418; 202 antibodies from 20 providers. DR Ensembl; ENSMUST00000099569.10; ENSMUSP00000097164.4; ENSMUSG00000052387.17. DR AGR; MGI:2443101; -. DR MGI; MGI:2443101; Trpm3. DR VEuPathDB; HostDB:ENSMUSG00000052387; -. DR GeneTree; ENSGT00940000157366; -. DR TreeFam; TF314204; -. DR ChiTaRS; Trpm3; mouse. DR Proteomes; UP000000589; Chromosome 19. DR Bgee; ENSMUSG00000052387; Expressed in pigmented layer of retina and 157 other cell types or tissues. DR ExpressionAtlas; F7CJ77; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005262; F:calcium channel activity; ISO:MGI. DR GO; GO:0005261; F:monoatomic cation channel activity; ISO:MGI. DR GO; GO:0070588; P:calcium ion transmembrane transport; ISO:MGI. DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central. DR GO; GO:0006812; P:monoatomic cation transport; ISO:MGI. DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro. DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR041491; TRPM_SLOG. DR InterPro; IPR032415; TRPM_tetra. DR InterPro; IPR037162; TRPM_tetra_sf. DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1. DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF18139; LSDAT_euk; 1. DR Pfam; PF16519; TRPM_tetra; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023303}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|MaxQB:F7CJ77, KW ECO:0007829|PeptideAtlas:F7CJ77}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}. FT TRANSMEM 745..764 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 812..830 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 842..860 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 881..901 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 959..984 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 2..290 FT /note="TRPM SLOG" FT /evidence="ECO:0000259|Pfam:PF18139" FT DOMAIN 752..993 FT /note="Ion transport" FT /evidence="ECO:0000259|Pfam:PF00520" FT DOMAIN 1087..1142 FT /note="TRPM tetramerisation" FT /evidence="ECO:0000259|Pfam:PF16519" FT REGION 676..698 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1307..1329 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1457..1579 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 1090..1148 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 678..698 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1307..1321 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1457..1475 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1478..1505 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1579 AA; 180236 MW; 98C0C6DFC8166579 CRC64; MYVRVSFDTK PDLLLHLMTK EWQLELPKLL ISVHGGLQNF ELQPKLKQVF GKGLIKAAMT TGAWIFTGGV NTGVIRHVGD ALKDHASKSR GKICTIGIAP WGIVENQEDL IGRDVVRPYQ TMSNPMSKLT VLNSMHSHFI LADNGTTGKY GAEVKLRRQL EKHISLQKIN TRCLPFFSLD SRLFYSFWGS CQLDPIGIGQ GVPVVALIVE GGPNVISIVL EYLRDTPPVP VVVCDGSGRA SDILAFGHKY SEEGGLINES LRDQLLVTIQ KTFTYTRTQA QHLFIILMEC MKKKELITVF RMGSEGHQDI DLAILTALLK GANASAPDQL SLALAWNRVD IARSQIFIYG QQWPVGSLEQ AMLDALVLDR VDFVKLLIEN GVSMHRFLTI SRLEELYNTR HGPSNTLYHL VRDVKKGNLP PDYRISLIDI GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG PKRPKALKLL GMEDDIPLRR GRKTTKKREE EVDIDLDDPE INHFPFPFHE LMVWAVLMKR QKMALFFWQH GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR DFGQLAVELL DQSYKQDEQL AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT DMWMGRLRMR KNSGLKVILG ILLPPSILSL EFKNKDDMPY MTQAQEIHLQ EKEPEEPEKP TKEKDEEDME LTAMLGRSNG ESSRKKDEEE VQSRHRLIPV GRKIYEFYNA PIVKFWFYTL AYIGYLMLFN YIVLVKMERW PSTQEWIVIS YIFTLGIEKM REILMSEPGK LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL RLQDQPFRSD GRVIYCVNII YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM MYFVIIMLVV LMSFGVARQA ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA DQIDPPCGQN ETREDGKTIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL IAVFNNTFFE VKSISNQVWK FQRYQLIMTF HERPVLPPPL IIFSHMTMIF QHVCCRWRKH ESDQDERDYG LKLFITDDEL KKVHDFEEQC IEEYFREKDD RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT VDIRLAQLED LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT FKLQESIDPA GEETISPTSP TLMPRMRSHS FYSVNVKDKG GIEKLESIFK ERSLSLHRAT SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD ELHCDIEPLD NSMNILGLGE PSFSALAPST TPSSSAYATL APTDRPPSRS IDFEDLTSMD TRSFSSDYTH LPECQNPWDT DPPTYHTIER SKSSRYLATT PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT DCIDTRCVNA PQAIADRATF PGGLGDKVED LSCCHPEREA ELSHPSSDSE ENEARGQRAA NPISSQEAEN ADRTLSNNIT VPKIERANSY SAEEPNVPYA HTRKSFSISD KLDRQRNTAS LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FHSFESKHN //