ID F7AYZ6_MOUSE Unreviewed; 81 AA. AC F7AYZ6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 02-OCT-2024, entry version 69. DE SubName: Full=Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 {ECO:0000313|Ensembl:ENSMUSP00000130715.2}; DE Flags: Fragment; GN Name=Slc6a12 {ECO:0000313|Ensembl:ENSMUSP00000130715.2, GN ECO:0000313|MGI:MGI:95628}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130715.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130715.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RG Mouse Genome Sequencing Consortium; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130715.2} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715.2}; RX PubMed=21750661; RA Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., RA Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D., RA Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L., RA Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J., RA Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P., RA Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G., RA Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.; RT "Modernizing reference genome assemblies."; RL PLoS Biol. 9:e1001091-e1001091(2011). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000130715.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715.2}; RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; F7AYZ6; -. DR Antibodypedia; 22038; 165 antibodies from 30 providers. DR Ensembl; ENSMUST00000165456.8; ENSMUSP00000130715.2; ENSMUSG00000030109.16. DR AGR; MGI:95628; -. DR MGI; MGI:95628; Slc6a12. DR VEuPathDB; HostDB:ENSMUSG00000030109; -. DR GeneTree; ENSGT00940000161075; -. DR HOGENOM; CLU_2580050_0_0_1; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030109; Expressed in decidua and 52 other cell types or tissues. DR ExpressionAtlas; F7AYZ6; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR037272; SNS_sf. DR PANTHER; PTHR11616:SF118; SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER; 1. DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1. DR Pfam; PF00209; SNF; 1. DR SUPFAM; SSF161070; SNF-like; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 4: Predicted; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..34 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000130715.2" SQ SEQUENCE 81 AA; 9180 MW; 7671D831BFB45079 CRC64; VVYFTATFPY LMLIILLIRG VTLPGAYQGI VFYLKPDLLR LKDPQGLHRP LLPEQCYQLR GWVCCLLHLG LHVSGAGNTH F //