ID F7AYZ6_MOUSE Unreviewed; 81 AA. AC F7AYZ6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 22-FEB-2023, entry version 60. DE SubName: Full=Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 {ECO:0000313|Ensembl:ENSMUSP00000130715.2}; DE Flags: Fragment; GN Name=Slc6a12 {ECO:0000313|Ensembl:ENSMUSP00000130715.2, GN ECO:0000313|MGI:MGI:95628}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130715.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130715.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130715.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715.2}; RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; F7AYZ6; -. DR Antibodypedia; 22038; 158 antibodies from 30 providers. DR Ensembl; ENSMUST00000165456.8; ENSMUSP00000130715.2; ENSMUSG00000030109.16. DR AGR; MGI:95628; -. DR MGI; MGI:95628; Slc6a12. DR VEuPathDB; HostDB:ENSMUSG00000030109; -. DR GeneTree; ENSGT00940000161075; -. DR HOGENOM; CLU_2580050_0_0_1; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030109; Expressed in decidua and 50 other tissues. DR ExpressionAtlas; F7AYZ6; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR037272; SNS_sf. DR PANTHER; PTHR11616:SF118; SODIUM- AND CHLORIDE-DEPENDENT BETAINE TRANSPORTER; 1. DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1. DR Pfam; PF00209; SNF; 1. DR SUPFAM; SSF161070; SNF-like; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 4: Predicted; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Symport {ECO:0000256|ARBA:ARBA00022847}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..34 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000130715.2" SQ SEQUENCE 81 AA; 9180 MW; 7671D831BFB45079 CRC64; VVYFTATFPY LMLIILLIRG VTLPGAYQGI VFYLKPDLLR LKDPQGLHRP LLPEQCYQLR GWVCCLLHLG LHVSGAGNTH F //