ID F7AYZ6_MOUSE Unreviewed; 81 AA. AC F7AYZ6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 05-DEC-2018, entry version 43. DE SubName: Full=Sodium- and chloride-dependent betaine transporter {ECO:0000313|Ensembl:ENSMUSP00000130715}; DE Flags: Fragment; GN Name=Slc6a12 {ECO:0000313|Ensembl:ENSMUSP00000130715, GN ECO:0000313|MGI:MGI:95628}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000130715, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000130715, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000130715} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000130715}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC153982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; F7AYZ6; -. DR SMR; F7AYZ6; -. DR PRIDE; F7AYZ6; -. DR Ensembl; ENSMUST00000165456; ENSMUSP00000130715; ENSMUSG00000030109. DR MGI; MGI:95628; Slc6a12. DR eggNOG; KOG3659; Eukaryota. DR eggNOG; COG0733; LUCA. DR GeneTree; ENSGT00940000161075; -. DR Reactome; R-MMU-352230; Amino acid transport across the plasma membrane. DR Reactome; R-MMU-442660; Na+/Cl- dependent neurotransmitter transporters. DR Reactome; R-MMU-71288; Creatine metabolism. DR Reactome; R-MMU-888593; Reuptake of GABA. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000030109; Expressed in 49 organ(s), highest expression level in decidua. DR ExpressionAtlas; F7AYZ6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR037272; SNS_sf. DR PANTHER; PTHR11616; PTHR11616; 1. DR Pfam; PF00209; SNF; 1. DR SUPFAM; SSF161070; SSF161070; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Membrane {ECO:0000256|SAAS:SAAS00943582, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Symport {ECO:0000256|SAAS:SAAS00943603}; KW Transmembrane {ECO:0000256|SAAS:SAAS00943611, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00943634, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00943587}. FT TRANSMEM 12 34 Helical. {ECO:0000256|SAM:Phobius}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000130715}. SQ SEQUENCE 81 AA; 9180 MW; 7671D831BFB45079 CRC64; VVYFTATFPY LMLIILLIRG VTLPGAYQGI VFYLKPDLLR LKDPQGLHRP LLPEQCYQLR GWVCCLLHLG LHVSGAGNTH F //