ID F6YZH6_MOUSE Unreviewed; 221 AA. AC F6YZH6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 12-AUG-2020, entry version 55. DE SubName: Full=Gamma-aminobutyric acid receptor subunit rho-2 {ECO:0000313|Ensembl:ENSMUSP00000114337}; DE Flags: Fragment; GN Name=Gabrr2 {ECO:0000313|Ensembl:ENSMUSP00000114337, GN ECO:0000313|MGI:MGI:95626}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114337, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000114337, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114337, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000114337} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114337}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|ARBA:ARBA00004169}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004169}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. CC {ECO:0000256|RuleBase:RU000687}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU000687}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL670464; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F6YZH6; -. DR Antibodypedia; 18718; 118 antibodies. DR Ensembl; ENSMUST00000147889; ENSMUSP00000114337; ENSMUSG00000023267. DR MGI; MGI:95626; Gabrr2. DR GeneTree; ENSGT00940000156864; -. DR HOGENOM; CLU_010920_6_0_1; -. DR ChiTaRS; Gabrr2; mouse. DR Proteomes; UP000000589; Chromosome 4. DR Bgee; ENSMUSG00000023267; Expressed in retinal neural layer and 80 other tissues. DR ExpressionAtlas; F6YZH6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 3: Inferred from homology; KW Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Chloride {ECO:0000256|ARBA:ARBA00023214}; KW Chloride channel {ECO:0000256|ARBA:ARBA00023173}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU000687}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687}; KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Synapse {ECO:0000256|ARBA:ARBA00023018}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000687}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU000687}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}. FT TRANSMEM 107..130 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT TRANSMEM 142..160 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT TRANSMEM 172..194 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT DOMAIN 2..106 FT /note="Neur_chan_LBD" FT /evidence="ECO:0000259|Pfam:PF02931" FT DOMAIN 114..211 FT /note="Neur_chan_memb" FT /evidence="ECO:0000259|Pfam:PF02932" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000114337" SQ SEQUENCE 221 AA; 25983 MW; 1A594CB0969BFABC CRC64; XIMLRVFPDG HVLYSMRITV TAMCNMDFSH FPLDSQTCSL ELESYAYTDE DLMLYWKNGD ESLKTDEKIS LSQFLIQKFH TTSRLAFYSS TGWYNRLYIN FTLRRHIFFF LLQTYFPATL MVMLSWVSFW IDHRAVPARV SLGIMTVLTM STIITGVNAS MPRVSYIRAV DIYLWVSFVF VFLSVLEYAA VNYLTTLQEQ KERKFREKVR RPRSSSLVSW G //