ID F6YZH6_MOUSE Unreviewed; 221 AA. AC F6YZH6; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 13-NOV-2019, entry version 50. DE SubName: Full=Gamma-aminobutyric acid receptor subunit rho-2 {ECO:0000313|Ensembl:ENSMUSP00000114337}; DE Flags: Fragment; GN Name=Gabrr2 {ECO:0000313|Ensembl:ENSMUSP00000114337, GN ECO:0000313|MGI:MGI:95626}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000114337, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000114337, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114337, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000114337} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000114337}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) CC family. {ECO:0000256|RuleBase:RU000687, CC ECO:0000256|SAAS:SAAS00978283}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|RuleBase:RU000687}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL670464; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F6YZH6; -. DR Ensembl; ENSMUST00000147889; ENSMUSP00000114337; ENSMUSG00000023267. DR MGI; MGI:95626; Gabrr2. DR eggNOG; KOG3643; Eukaryota. DR eggNOG; ENOG410XPWH; LUCA. DR GeneTree; ENSGT00940000156864; -. DR ChiTaRS; Gabrr2; mouse. DR Proteomes; UP000000589; Chromosome 4. DR Bgee; ENSMUSG00000023267; Expressed in 50 organ(s), highest expression level in retina. DR ExpressionAtlas; F6YZH6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR Gene3D; 2.70.170.10; -; 1. DR InterPro; IPR006028; GABAA/Glycine_rcpt. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR PANTHER; PTHR18945; PTHR18945; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00253; GABAARECEPTR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF63712; SSF63712; 1. DR SUPFAM; SSF90112; SSF90112; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|SAAS:SAAS00457684}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Ion channel {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00081334}; KW Ion transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457623}; KW Membrane {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00978300}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00978734}; KW Transmembrane helix {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00978768}; KW Transport {ECO:0000256|RuleBase:RU000687, KW ECO:0000256|SAAS:SAAS00457659}. FT TRANSMEM 107 130 Helical. {ECO:0000256|RuleBase:RU000687}. FT TRANSMEM 142 160 Helical. {ECO:0000256|RuleBase:RU000687}. FT TRANSMEM 172 194 Helical. {ECO:0000256|RuleBase:RU000687}. FT DOMAIN 2 106 Neur_chan_LBD. {ECO:0000259|Pfam: FT PF02931}. FT DOMAIN 114 211 Neur_chan_memb. {ECO:0000259|Pfam: FT PF02932}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000114337}. SQ SEQUENCE 221 AA; 25983 MW; 1A594CB0969BFABC CRC64; XIMLRVFPDG HVLYSMRITV TAMCNMDFSH FPLDSQTCSL ELESYAYTDE DLMLYWKNGD ESLKTDEKIS LSQFLIQKFH TTSRLAFYSS TGWYNRLYIN FTLRRHIFFF LLQTYFPATL MVMLSWVSFW IDHRAVPARV SLGIMTVLTM STIITGVNAS MPRVSYIRAV DIYLWVSFVF VFLSVLEYAA VNYLTTLQEQ KERKFREKVR RPRSSSLVSW G //