ID F6VNH1_MOUSE Unreviewed; 154 AA. AC F6VNH1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 18-SEP-2013, sequence version 2. DT 24-JUL-2024, entry version 72. DE SubName: Full=Transcription factor 7 like 1 (T cell specific, HMG box) {ECO:0000313|Ensembl:ENSMUSP00000115060.3}; DE Flags: Fragment; GN Name=Tcf7l1 {ECO:0000313|Ensembl:ENSMUSP00000115060.3, GN ECO:0000313|MGI:MGI:1202876}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115060.3, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000115060.3} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115060.3}; RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; F6VNH1; -. DR ProteomicsDB; 361323; -. DR Antibodypedia; 31794; 180 antibodies from 35 providers. DR Ensembl; ENSMUST00000149446.3; ENSMUSP00000115060.3; ENSMUSG00000055799.14. DR AGR; MGI:1202876; -. DR MGI; MGI:1202876; Tcf7l1. DR VEuPathDB; HostDB:ENSMUSG00000055799; -. DR GeneTree; ENSGT00940000157038; -. DR HOGENOM; CLU_085920_0_0_1; -. DR ChiTaRS; Tcf7l1; mouse. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000055799; Expressed in internal carotid artery and 250 other cell types or tissues. DR ExpressionAtlas; F6VNH1; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro. DR InterPro; IPR013558; CTNNB1-bd_N. DR InterPro; IPR024940; TCF/LEF. DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1. DR PANTHER; PTHR10373:SF25; TRANSCRIPTION FACTOR 7-LIKE 1; 1. DR Pfam; PF08347; CTNNB1_binding; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 7..128 FT /note="CTNNB1 binding N-teminal" FT /evidence="ECO:0000259|Pfam:PF08347" FT REGION 105..154 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115060.3" FT NON_TER 154 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115060.3" SQ SEQUENCE 154 AA; 16877 MW; F2D4451272566C08 CRC64; DAFQKPRDYF AEVRRPQDGA FFKGPAYPGY PFLMIPDLSS PYLSNGPLSP GGARTYLQMK WPLLDVPSSA TVKDTRSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNDHF SPASPPTHLS PEIDPKTGAV GQIPHPLGWL VPQQGQPMYS LPPG //