ID F6VNH1_MOUSE Unreviewed; 154 AA. AC F6VNH1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 18-SEP-2013, sequence version 2. DT 28-MAR-2018, entry version 42. DE SubName: Full=Transcription factor 7-like 1 {ECO:0000313|Ensembl:ENSMUSP00000115060}; DE Flags: Fragment; GN Name=Tcf7l1 {ECO:0000313|Ensembl:ENSMUSP00000115060, GN ECO:0000313|MGI:MGI:1202876}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115060, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115060, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115060, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115060} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115060}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., RA Vemulapalli V., Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC125039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC153613; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000149446; ENSMUSP00000115060; ENSMUSG00000055799. DR MGI; MGI:1202876; Tcf7l1. DR GeneTree; ENSGT00390000009964; -. DR Reactome; R-MMU-201722; Formation of the beta-catenin:TCF transactivating complex. DR Reactome; R-MMU-3769402; Deactivation of the beta-catenin transactivating complex. DR Reactome; R-MMU-4641265; Repression of WNT target genes. DR Reactome; R-MMU-8951430; RUNX3 regulates WNT signaling. DR ChiTaRS; Tcf7l1; mouse. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000055799; -. DR ExpressionAtlas; F6VNH1; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro. DR InterPro; IPR013558; CTNNB1-bd_N. DR InterPro; IPR024940; TCF/LEF. DR InterPro; IPR028773; TCF7L. DR PANTHER; PTHR10373; PTHR10373; 2. DR PANTHER; PTHR10373:SF25; PTHR10373:SF25; 2. DR Pfam; PF08347; CTNNB1_binding; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 4 128 CTNNB1_binding. {ECO:0000259|Pfam: FT PF08347}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000115060}. FT NON_TER 154 154 {ECO:0000313|Ensembl:ENSMUSP00000115060}. SQ SEQUENCE 154 AA; 16877 MW; F2D4451272566C08 CRC64; DAFQKPRDYF AEVRRPQDGA FFKGPAYPGY PFLMIPDLSS PYLSNGPLSP GGARTYLQMK WPLLDVPSSA TVKDTRSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNDHF SPASPPTHLS PEIDPKTGAV GQIPHPLGWL VPQQGQPMYS LPPG //