ID F6VNH1_MOUSE Unreviewed; 154 AA. AC F6VNH1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 18-SEP-2013, sequence version 2. DT 20-JAN-2016, entry version 32. DE SubName: Full=Transcription factor 7-like 1 {ECO:0000313|Ensembl:ENSMUSP00000115060}; DE Flags: Fragment; GN Name=Tcf7l1 {ECO:0000313|Ensembl:ENSMUSP00000115060, GN ECO:0000313|MGI:MGI:1202876}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115060, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115060, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115060, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115060} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115060}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000115060}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC125039; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC153613; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMUST00000149446; ENSMUSP00000115060; ENSMUSG00000055799. DR MGI; MGI:1202876; Tcf7l1. DR GeneTree; ENSGT00390000009964; -. DR ChiTaRS; Tcf7l1; mouse. DR NextBio; 35557770; -. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; F6VNH1; -. DR ExpressionAtlas; F6VNH1; baseline and differential. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0008013; F:beta-catenin binding; IPI:MGI. DR GO; GO:0003682; F:chromatin binding; IDA:MGI. DR GO; GO:0003677; F:DNA binding; IDA:MGI. DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:MGI. DR GO; GO:0044212; F:transcription regulatory region DNA binding; IBA:GO_Central. DR GO; GO:0008595; P:anterior/posterior axis specification, embryo; IMP:MGI. DR GO; GO:0048319; P:axial mesoderm morphogenesis; IMP:MGI. DR GO; GO:0007420; P:brain development; IBA:GO_Central. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central. DR GO; GO:0048699; P:generation of neurons; IBA:GO_Central. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI. DR GO; GO:0046022; P:positive regulation of transcription from RNA polymerase II promoter during mitosis; IDA:MGI. DR GO; GO:2000036; P:regulation of stem cell population maintenance; IMP:MGI. DR GO; GO:0043588; P:skin development; IGI:MGI. DR GO; GO:0035019; P:somatic stem cell population maintenance; IGI:MGI. DR GO; GO:0048863; P:stem cell differentiation; IMP:MGI. DR InterPro; IPR013558; CTNNB1-bd_N. DR InterPro; IPR024940; TCF/LEF. DR InterPro; IPR028778; Tcf7l1. DR PANTHER; PTHR10373; PTHR10373; 1. DR PANTHER; PTHR10373:SF25; PTHR10373:SF25; 1. DR Pfam; PF08347; CTNNB1_binding; 1. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 4 128 CTNNB1_binding. {ECO:0000259|Pfam: FT PF08347}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000115060}. FT NON_TER 154 154 {ECO:0000313|Ensembl:ENSMUSP00000115060}. SQ SEQUENCE 154 AA; 16877 MW; F2D4451272566C08 CRC64; DAFQKPRDYF AEVRRPQDGA FFKGPAYPGY PFLMIPDLSS PYLSNGPLSP GGARTYLQMK WPLLDVPSSA TVKDTRSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNDHF SPASPPTHLS PEIDPKTGAV GQIPHPLGWL VPQQGQPMYS LPPG //