ID F6V0D3_MONDO Unreviewed; 184 AA. AC F6V0D3; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 03-AUG-2022, entry version 60. DE RecName: Full=Gremlin {ECO:0000256|PIRNR:PIRNR037254}; GN Name=GREM1 {ECO:0000313|Ensembl:ENSMODP00000033697}; OS Monodelphis domestica (Gray short-tailed opossum). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis. OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000033697, ECO:0000313|Proteomes:UP000002280}; RN [1] {ECO:0000313|Ensembl:ENSMODP00000033697, ECO:0000313|Proteomes:UP000002280} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=17495919; DOI=10.1038/nature05805; RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V., RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., RA Samollow P.B., Lander E.S., Lindblad-Toh K.; RT "Genome of the marsupial Monodelphis domestica reveals innovation in non- RT coding sequences."; RL Nature 447:167-177(2007). RN [2] {ECO:0000313|Ensembl:ENSMODP00000033697} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|PIRNR:PIRNR037254}. CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872, CC ECO:0000256|PIRNR:PIRNR037254}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_007480060.1; XM_007479998.2. DR STRING; 13616.ENSMODP00000033697; -. DR Ensembl; ENSMODT00000001764; ENSMODP00000033697; ENSMODG00000001426. DR GeneID; 100031599; -. DR KEGG; mdo:100031599; -. DR CTD; 26585; -. DR eggNOG; ENOG502QQ5X; Eukaryota. DR GeneTree; ENSGT00940000154209; -. DR HOGENOM; CLU_101024_0_0_1; -. DR InParanoid; F6V0D3; -. DR OrthoDB; 1270652at2759; -. DR TreeFam; TF106445; -. DR Proteomes; UP000002280; Chromosome 1. DR Bgee; ENSMODG00000001426; Expressed in hindlimb bud and 15 other tissues. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0036122; F:BMP binding; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central. DR GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl. DR GO; GO:0043184; F:vascular endothelial growth factor receptor 2 binding; IEA:Ensembl. DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central. DR GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl. DR GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; IEA:Ensembl. DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl. DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl. DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl. DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl. DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl. DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl. DR GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:1900158; P:negative regulation of bone mineralization involved in bone maturation; IEA:Ensembl. DR GO; GO:0046851; P:negative regulation of bone remodeling; IEA:Ensembl. DR GO; GO:1900155; P:negative regulation of bone trabecula formation; IEA:Ensembl. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl. DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl. DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl. DR GO; GO:0033689; P:negative regulation of osteoblast proliferation; IEA:Ensembl. DR GO; GO:0090291; P:negative regulation of osteoclast proliferation; IEA:Ensembl. DR GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl. DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl. DR GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl. DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl. DR GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; IEA:Ensembl. DR GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl. DR GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl. DR GO; GO:0051973; P:positive regulation of telomerase activity; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl. DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IEA:Ensembl. DR GO; GO:0051893; P:regulation of focal adhesion assembly; IEA:Ensembl. DR GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IBA:GO_Central. DR GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR004133; DAN. DR InterPro; IPR017159; Gremlin-1/2. DR Pfam; PF03045; DAN; 1. DR PIRSF; PIRSF037254; Gremlin_precursor; 1. DR SMART; SM00041; CT; 1. PE 3: Inferred from homology; KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR037254}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR037254-1}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Hormone {ECO:0000256|ARBA:ARBA00022702}; KW Reference proteome {ECO:0000313|Proteomes:UP000002280}; KW Secreted {ECO:0000256|PIRNR:PIRNR037254}; KW Signal {ECO:0000256|PIRNR:PIRNR037254}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|PIRNR:PIRNR037254" FT CHAIN 25..184 FT /note="Gremlin" FT /evidence="ECO:0000256|PIRNR:PIRNR037254" FT /id="PRO_5005153395" FT DOMAIN 96..183 FT /note="CTCK" FT /evidence="ECO:0000259|SMART:SM00041" FT REGION 24..77 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 40..59 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 94..144 FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1" FT DISULFID 108..158 FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1" FT DISULFID 118..176 FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1" FT DISULFID 122..178 FT /evidence="ECO:0000256|PIRSR:PIRSR037254-1" SQ SEQUENCE 184 AA; 20771 MW; CAD7128B604A4517 CRC64; MGRTAYTVGA LLLLLGTLLS ATEGKKKGSQ GAIPPPDKDQ YNDSEQTQTP QQPGSRNRGR GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS IDLD //