ID F6UIS1_MOUSE Unreviewed; 246 AA. AC F6UIS1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 24-JUL-2024, entry version 63. DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013}; DE Flags: Fragment; GN Name=Ergic3 {ECO:0000313|Ensembl:ENSMUSP00000115912.2, GN ECO:0000313|MGI:MGI:1913616}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115912.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000115912.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115912.2}; RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and CC Golgi. {ECO:0000256|RuleBase:RU369013}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi CC intermediate compartment membrane {ECO:0000256|RuleBase:RU369013}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369013}. Golgi CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU369013}. Golgi apparatus, cis-Golgi CC network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane CC protein {ECO:0000256|ARBA:ARBA00004257}. CC -!- SIMILARITY: Belongs to the ERGIC family. CC {ECO:0000256|RuleBase:RU369013}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR PeptideAtlas; F6UIS1; -. DR ProteomicsDB; 373794; -. DR Antibodypedia; 3001; 266 antibodies from 31 providers. DR Ensembl; ENSMUST00000142859.8; ENSMUSP00000115912.2; ENSMUSG00000005881.14. DR AGR; MGI:1913616; -. DR MGI; MGI:1913616; Ergic3. DR VEuPathDB; HostDB:ENSMUSG00000005881; -. DR GeneTree; ENSGT00530000063113; -. DR HOGENOM; CLU_034705_1_2_1; -. DR ChiTaRS; Ergic3; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000005881; Expressed in molar tooth and 262 other cell types or tissues. DR ExpressionAtlas; F6UIS1; baseline and differential. DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule. DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule. DR InterPro; IPR045888; Erv. DR InterPro; IPR012936; Erv_C. DR PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1. DR PANTHER; PTHR10984:SF25; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3; 1. DR Pfam; PF07970; COPIIcoated_ERV; 1. PE 1: Evidence at protein level; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013}; KW ER-Golgi transport {ECO:0000256|RuleBase:RU369013}; KW Golgi apparatus {ECO:0000256|RuleBase:RU369013}; KW Proteomics identification {ECO:0007829|PeptideAtlas:F6UIS1, KW ECO:0007829|ProteomicsDB:F6UIS1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transport {ECO:0000256|RuleBase:RU369013}. FT DOMAIN 74..244 FT /note="Endoplasmic reticulum vesicle transporter C- FT terminal" FT /evidence="ECO:0000259|Pfam:PF07970" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115912.2" FT NON_TER 246 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115912.2" SQ SEQUENCE 246 AA; 28001 MW; 9F3DC11358AFEB49 CRC64; XDVLFPHMPC AYLSIDAMDV AGEQQLDVEH NLFKKRLDKD GVPVSSEAER HELGKVEVTV FDPNSLDPNR CESCYGAESE DIKCCNSCED VREAYRRRGW AFKNPDTIEQ CRREGFSQKM QEQKNEGCQV YGFLEVNKVA GNFHFAPGKS FQQSHVHVHA VEIHDLQSFG LDNINMTHYI KHLSFGEDYP GIVNPLDHTN VTAPQASMMF QYFVKVVPTV YMKVDGEVLR TNQFSVTRHE KVANGL //