ID F6UIS1_MOUSE Unreviewed; 246 AA. AC F6UIS1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 12-OCT-2022, entry version 53. DE RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013}; DE Flags: Fragment; GN Name=Ergic3 {ECO:0000313|Ensembl:ENSMUSP00000115912, GN ECO:0000313|MGI:MGI:1913616}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115912, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115912, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115912, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000115912} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115912}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and CC Golgi. {ECO:0000256|RuleBase:RU369013}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi CC intermediate compartment membrane {ECO:0000256|RuleBase:RU369013}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369013}. Golgi CC apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU369013}. CC -!- SIMILARITY: Belongs to the ERGIC family. CC {ECO:0000256|RuleBase:RU369013}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EPD; F6UIS1; -. DR PeptideAtlas; F6UIS1; -. DR PRIDE; F6UIS1; -. DR ProteomicsDB; 373794; -. DR Antibodypedia; 3001; 256 antibodies from 30 providers. DR Ensembl; ENSMUST00000142859.8; ENSMUSP00000115912.2; ENSMUSG00000005881.14. DR MGI; MGI:1913616; Ergic3. DR VEuPathDB; HostDB:ENSMUSG00000005881; -. DR GeneTree; ENSGT00530000063113; -. DR HOGENOM; CLU_034705_1_2_1; -. DR ChiTaRS; Ergic3; mouse. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000005881; Expressed in molar tooth and 259 other tissues. DR ExpressionAtlas; F6UIS1; baseline and differential. DR InterPro; IPR045888; Erv. DR InterPro; IPR012936; Erv_C. DR PANTHER; PTHR10984; PTHR10984; 1. DR Pfam; PF07970; COPIIcoated_ERV; 1. PE 1: Evidence at protein level; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013}; KW ER-Golgi transport {ECO:0000256|RuleBase:RU369013}; KW Golgi apparatus {ECO:0000256|RuleBase:RU369013}; KW Proteomics identification {ECO:0007829|EPD:F6UIS1, KW ECO:0007829|MaxQB:F6UIS1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transport {ECO:0000256|RuleBase:RU369013}. FT DOMAIN 74..244 FT /note="COPIIcoated_ERV" FT /evidence="ECO:0000259|Pfam:PF07970" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115912" FT NON_TER 246 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115912" SQ SEQUENCE 246 AA; 28001 MW; 9F3DC11358AFEB49 CRC64; XDVLFPHMPC AYLSIDAMDV AGEQQLDVEH NLFKKRLDKD GVPVSSEAER HELGKVEVTV FDPNSLDPNR CESCYGAESE DIKCCNSCED VREAYRRRGW AFKNPDTIEQ CRREGFSQKM QEQKNEGCQV YGFLEVNKVA GNFHFAPGKS FQQSHVHVHA VEIHDLQSFG LDNINMTHYI KHLSFGEDYP GIVNPLDHTN VTAPQASMMF QYFVKVVPTV YMKVDGEVLR TNQFSVTRHE KVANGL //