ID F6TJZ1_XENTR Unreviewed; 210 AA. AC F6TJZ1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 3. DT 02-DEC-2020, entry version 42. DE RecName: Full=Non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903}; DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903}; GN Name=btg5.3 {ECO:0000313|Ensembl:ENSXETP00000008843}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000008843, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000008843, ECO:0000313|Proteomes:UP000008143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000008843, RC ECO:0000313|Proteomes:UP000008143}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J., RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., RA Khokha M.K., Richardson P.M., Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000008843} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; CC Evidence={ECO:0000256|ARBA:ARBA00001149}; CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004413}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 8364.ENSXETP00000008843; -. DR PaxDb; F6TJZ1; -. DR Ensembl; ENSXETT00000008843; ENSXETP00000008843; ENSXETG00000004087. DR Xenbase; XB-GENE-5805799; btg5.3. DR eggNOG; KOG4006; Eukaryota. DR GeneTree; ENSGT00940000157269; -. DR GeneTree; ENSGT00950000182952; -. DR HOGENOM; CLU_079660_0_0_1; -. DR InParanoid; F6TJZ1; -. DR TreeFam; TF105272; -. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000004087; Expressed in gastrula and 8 other tissues. DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:InterPro. DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central. DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central. DR GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:InterPro. DR GO; GO:0045765; P:regulation of angiogenesis; IEA:InterPro. DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0002688; P:regulation of leukocyte chemotaxis; IEA:InterPro. DR GO; GO:0007172; P:signal complex assembly; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd14473; FERM_B-lobe; 1. DR CDD; cd13190; FERM_C_FAK1; 1. DR Gene3D; 1.20.80.10; -; 1. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR041390; FADK_N. DR InterPro; IPR041784; FAK1/PYK2_FERM_C. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR036137; Focal_adhe_kin_target_dom_sf. DR InterPro; IPR005189; Focal_adhesion_kin_target_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR030610; PTK2B. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR24418:SF94; PTHR24418:SF94; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF18038; FERM_N_2; 1. DR Pfam; PF03623; Focal_AT; 2. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00295; B41; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF47031; SSF47031; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF68993; SSF68993; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Kinase {ECO:0000256|ARBA:ARBA00023137}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transferase {ECO:0000256|ARBA:ARBA00023137}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}. SQ SEQUENCE 210 AA; 23763 MW; EF06DDC2252C4FB1 CRC64; ACRFHRLDPM VVEAFGERLV EILCRRYTGH WYPEKPMKGQ AYRCIRINRH QTDESIAEAC ALCGISYTDL SLPKEITLWI DPYEVSCRLR EKNHPFTVAS FDPRDSRVLS TSLESKTPAS PSDSGIDCSS PGLSSWVGDR GEDMDSGNDS SNEELTHIYS EQVAWTPGGV CLTPTTTSLY RTSSPLWIPT WRAADYMYNT MNSTEPGFWM //