ID F6TJZ1_XENTR Unreviewed; 971 AA. AC F6TJZ1; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 11-DEC-2019, sequence version 2. DT 12-AUG-2020, entry version 40. DE RecName: Full=Non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903}; DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903}; GN Name=ptk2b {ECO:0000313|Ensembl:ENSXETP00000100851}; GN Synonyms=btg5.3 {ECO:0000313|Ensembl:ENSXETP00000008843}; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000008843, ECO:0000313|Proteomes:UP000008143}; RN [1] {ECO:0000313|Ensembl:ENSXETP00000008843, ECO:0000313|Proteomes:UP000008143} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000008843, RC ECO:0000313|Proteomes:UP000008143}; RX PubMed=20431018; DOI=10.1126/science.1183670; RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J., RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., RA Khokha M.K., Richardson P.M., Rokhsar D.S.; RT "The genome of the Western clawed frog Xenopus tropicalis."; RL Science 328:633-636(2010). RN [2] {ECO:0000313|Ensembl:ENSXETP00000008843} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSXETP00000100851} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2020) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; CC Evidence={ECO:0000256|ARBA:ARBA00001149}; CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion CC {ECO:0000256|ARBA:ARBA00004246}. Cell membrane CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004413}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR STRING; 8364.ENSXETP00000008843; -. DR PaxDb; F6TJZ1; -. DR Ensembl; ENSXETT00000008843; ENSXETP00000008843; ENSXETG00000004087. DR Ensembl; ENSXETT00000097807; ENSXETP00000100851; ENSXETG00000017538. DR Xenbase; XB-GENE-5805799; btg5.3. DR Xenbase; XB-GENE-489525; ptk2b. DR eggNOG; KOG4006; Eukaryota. DR GeneTree; ENSGT00950000182952; -. DR HOGENOM; CLU_079660_0_0_1; -. DR InParanoid; F6TJZ1; -. DR TreeFam; TF105272; -. DR Proteomes; UP000008143; Unassembled WGS sequence. DR Bgee; ENSXETG00000004087; Expressed in gastrula and 8 other tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro. DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:InterPro. DR GO; GO:0005925; C:focal adhesion; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:InterPro. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central. DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central. DR GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:InterPro. DR GO; GO:0045765; P:regulation of angiogenesis; IEA:InterPro. DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro. DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro. DR GO; GO:0002688; P:regulation of leukocyte chemotaxis; IEA:InterPro. DR GO; GO:0007172; P:signal complex assembly; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd14473; FERM_B-lobe; 1. DR CDD; cd13190; FERM_C_FAK1; 1. DR Gene3D; 1.20.80.10; -; 1. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR041390; FADK_N. DR InterPro; IPR041784; FAK1/PYK2_FERM_C. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR036137; Focal_adhe_kin_target_dom_sf. DR InterPro; IPR005189; Focal_adhesion_kin_target_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR030610; PTK2B. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR24418:SF94; PTHR24418:SF94; 1. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF18038; FERM_N_2; 1. DR Pfam; PF03623; Focal_AT; 2. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00295; B41; 1. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF47031; SSF47031; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR SUPFAM; SSF56112; SSF56112; 1. DR SUPFAM; SSF68993; SSF68993; 1. DR PROSITE; PS50057; FERM_3; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Cell junction {ECO:0000256|ARBA:ARBA00022949}; KW Cell projection {ECO:0000256|ARBA:ARBA00023273}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Kinase {ECO:0000256|ARBA:ARBA00023137}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000008143}; KW Transferase {ECO:0000256|ARBA:ARBA00023137}; KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}. FT DOMAIN 35..355 FT /note="FERM" FT /evidence="ECO:0000259|PROSITE:PS50057" FT DOMAIN 405..663 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 670..700 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 784..804 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 905..925 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 971 AA; 111233 MW; 5712E84734B020EB CRC64; MSLDHANRTK GGTFNRPDGP AEVPAEVEIS KEEMRILKVC FHSNSSNLVK NFKLVKCSIY TDIQEIISSI LLSGRIGPDI KHVECYGLRL KHLKSDEIHW LHPELTVGEV QEKYECLHLE AEWRYDLRIR YLPEDFNESF KKDKTTLLYF YQQLRNDYMQ QYATKVSEGM ALQLGCLELR RFYKDMPQNA LEKKSNFEFL EKEVGLDLFF PKQMQESLKP KQFRKMIQQT FQQYGSLKEE ECITRFMNTL STFTSIDQET YRCELAQGWS ITVDLVIGPK GIRQLTTKDS KPTCFAEFKQ IKSIKCSLLE DGWALLLLGI SGAPQPLAIK TSSLAVAENM ADLIDGYCRL QNESKDSLIV NPKKGENLPE LGKRALLQDS DIYAEIPESG WRATDNRFTI SRSDVALGRI LGEGFFGEVY DGVYVKPKGD KINVAVKTCK NDCAADVKEK FMSEAYLMRN LDHPHIVKLI GIIEDDPIWI VMELYPYGEL GQYLEKNKNS LQVLSLILYS LQICKALAYL EGINCVHRDI AVRNILVASP ECVKLGDFGL SRYLEEEEYY KASVTRLPIK WMAPESINFR RFTSASDVWM FGVCMWEILS FGKQPFFWLE NKDVISVIEK GDRLPKPEMC PPTLYTLMTR CWTYDPFERP KFTELVCSLS DIYQTEKEII KDKERNNRQR PPKIIEPPPM QEPPPKVSRR SFSTLPVSVL LCSLTAQVPE SLCASSPTLC SPTDYQSPLD STRSPPLPRH SIFKRRSMRE EDFVKPNSKE EAQKLWEKER DKMLQVLNRQ QQQMEEDGKW LKQEEKSLAN TLKVSHTSPS FLTNPLFLFF VAEFTVPPQK PPRLGAQPTP TANIDRTDDG VYQSVMELVK AVLQLKNDIY QLPPEGYVAV VKVRERIPAT IEGTQKLLSK DLAELINKMR LAQQNAVTSL SEECKKQMLT ASHTMAVDAK NLLDAVDQAR VRANLAKVAA E //