ID F6SUV7_MOUSE Unreviewed; 957 AA. AC F6SUV7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 28-JUN-2023, entry version 77. DE SubName: Full=TBC1 domain family, member 4 {ECO:0000313|Ensembl:ENSMUSP00000124511.2}; DE Flags: Fragment; GN Name=Tbc1d4 {ECO:0000313|Ensembl:ENSMUSP00000124511.2, GN ECO:0000313|MGI:MGI:2429660}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000124511.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000124511.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124511.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0007829|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [4] {ECO:0000313|Ensembl:ENSMUSP00000124511.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124511.2}; RG Ensembl; RL Submitted (MAR-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR jPOST; F6SUV7; -. DR MaxQB; F6SUV7; -. DR PeptideAtlas; F6SUV7; -. DR ProteomicsDB; 318549; -. DR Antibodypedia; 3177; 545 antibodies from 40 providers. DR Ensembl; ENSMUST00000159951.8; ENSMUSP00000124511.2; ENSMUSG00000033083.17. DR AGR; MGI:2429660; -. DR MGI; MGI:2429660; Tbc1d4. DR VEuPathDB; HostDB:ENSMUSG00000033083; -. DR GeneTree; ENSGT00940000158486; -. DR HOGENOM; CLU_005350_13_2_1; -. DR ChiTaRS; Tbc1d4; mouse. DR Proteomes; UP000000589; Chromosome 14. DR Bgee; ENSMUSG00000033083; Expressed in temporalis muscle and 203 other tissues. DR ExpressionAtlas; F6SUV7; baseline and differential. DR CDD; cd01269; PTB_TBC1D1_like; 1. DR Gene3D; 1.10.10.2750; -; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1. DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1. DR InterPro; IPR021785; DUF3350. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR006020; PTB/PI_dom. DR InterPro; IPR000195; Rab-GAP-TBC_dom. DR InterPro; IPR035969; Rab-GAP_TBC_sf. DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1. DR PANTHER; PTHR47219:SF5; TBC1 DOMAIN FAMILY MEMBER 1; 1. DR Pfam; PF11830; DUF3350; 1. DR Pfam; PF00640; PID; 1. DR Pfam; PF00566; RabGAP-TBC; 1. DR SMART; SM00462; PTB; 1. DR SMART; SM00164; TBC; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2. DR PROSITE; PS01179; PID; 1. DR PROSITE; PS50086; TBC_RABGAP; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Proteomics identification {ECO:0007829|EPD:F6SUV7, KW ECO:0007829|MaxQB:F6SUV7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 86..158 FT /note="PID" FT /evidence="ECO:0000259|PROSITE:PS01179" FT DOMAIN 577..771 FT /note="Rab-GAP TBC" FT /evidence="ECO:0000259|PROSITE:PS50086" FT REGION 42..72 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 305..423 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 858..927 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 403..421 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000124511.2" SQ SEQUENCE 957 AA; 109339 MW; 7B143361145BBC29 CRC64; XLASQPALAS SRVCFPERIL EDCGFDEQQE FRSRCSSVTG VMQKKVHENN QKTQPRRRHA SAPSHVQPSD SEKNRTMLFQ VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF ICRESPEPGL SQYICYVFQC ANESLVDEVM LTLKQAFSTA AALQSAKTQI KLCETCPMHS LHKLCERIEG LYPPRAKLVI QRHLSSLTDN EQADIFERVQ KMKPISDQEE NELVILHLRQ LCEAKQRTHV HIGEGPAIIS NSTIPENVTS GGRFKLDVLK NKAKRSLTSS LENIFSRGAN RMRGRLGSMD SFERANSLAS EKDFSPGDSP PGTPPASPLS SAWHAFPEED SDSPQFRRRA HTFSHPPSSS RRKLNLQDGK AHGLRSPLLR QSSSEQCSDG EGRKRTSSTC SNESLNAGGT PVTPRRVSWR QRIFLRVASP VNKSPSAMQQ QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE KKKSKELKSL WKKAIHQQIL LLRMEKENQK LEEARRDELQ SRKVKLDYEE VGTCQKEILI AWDKKLLNCR TKIRCDMEDI HTSLKEGVPK SRRGEIWQFL ALQYRLRHRL PNKHQPPDTS YKELLKQLTA QQHAILVDLG RTFPTHPYFS VQLGAGQLSL FNLLKAYSLL DKEVGYCQGI SFVAGVLLLH MSEEQAFEML KFLMYDLGFR KQYRPDMMSL QIQMYQLSRL LHDYHRELYN HLEENEISPS LYAAPWFLTL FASQFPLGFV ARVFDIIFLQ GTEVIFKVAL SLLSSQEALI MECENFENIV EFLKSTLPDM NTTEMEKIIT QVFEMDISKQ LHAYEVEYHV LQDELLESSY ACEDNESLEK LERANNQLKR QNMDLLEKLQ VAHAKIQALE SNLETLLTRE TKMKALIRTL EQDKMAYQKT VEQIRKLLPA DALANCELLL KDLTHPTNDK AKAGNKP //