ID F6SUV7_MOUSE Unreviewed; 957 AA. AC F6SUV7; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 25-APR-2018, entry version 53. DE SubName: Full=TBC1 domain family member 4 {ECO:0000313|Ensembl:ENSMUSP00000124511}; DE Flags: Fragment; GN Name=Tbc1d4 {ECO:0000313|Ensembl:ENSMUSP00000124511, GN ECO:0000313|MGI:MGI:2429660}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000124511, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000124511, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124511, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000124511} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000124511}; RG Ensembl; RL Submitted (JUN-2011) to UniProtKB. RN [4] {ECO:0000213|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., RA Vemulapalli V., Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CT025630; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT573019; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CT573033; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR MaxQB; F6SUV7; -. DR PeptideAtlas; F6SUV7; -. DR Ensembl; ENSMUST00000159951; ENSMUSP00000124511; ENSMUSG00000033083. DR MGI; MGI:2429660; Tbc1d4. DR eggNOG; KOG4436; Eukaryota. DR eggNOG; ENOG410YWJY; LUCA. DR GeneTree; ENSGT00750000117238; -. DR Reactome; R-MMU-1445148; Translocation of GLUT4 to the plasma membrane. DR ChiTaRS; Tbc1d4; mouse. DR Proteomes; UP000000589; Chromosome 14. DR Bgee; ENSMUSG00000033083; -. DR ExpressionAtlas; F6SUV7; baseline and differential. DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR021785; DUF3350. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR006020; PTB/PI_dom. DR InterPro; IPR000195; Rab-GTPase-TBC_dom. DR InterPro; IPR035969; Rab-GTPase_TBC_sf. DR InterPro; IPR033564; TBC1D4. DR PANTHER; PTHR22957:SF195; PTHR22957:SF195; 2. DR Pfam; PF11830; DUF3350; 1. DR Pfam; PF00640; PID; 1. DR Pfam; PF00566; RabGAP-TBC; 1. DR SMART; SM00462; PTB; 1. DR SMART; SM00164; TBC; 1. DR SUPFAM; SSF47923; SSF47923; 2. DR PROSITE; PS01179; PID; 1. DR PROSITE; PS50086; TBC_RABGAP; 1. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|EPD:F6SUV7, KW ECO:0000213|MaxQB:F6SUV7, ECO:0000213|PeptideAtlas:F6SUV7}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 86 158 PID. {ECO:0000259|PROSITE:PS01179}. FT DOMAIN 577 771 Rab-GAP TBC. {ECO:0000259|PROSITE: FT PS50086}. FT COILED 507 532 {ECO:0000256|SAM:Coils}. FT COILED 858 899 {ECO:0000256|SAM:Coils}. FT COILED 907 927 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSMUSP00000124511}. SQ SEQUENCE 957 AA; 109339 MW; 7B143361145BBC29 CRC64; XLASQPALAS SRVCFPERIL EDCGFDEQQE FRSRCSSVTG VMQKKVHENN QKTQPRRRHA SAPSHVQPSD SEKNRTMLFQ VGRFEINLIS PDTKSVVLEK NFKDISSCSQ GIKHVDHFGF ICRESPEPGL SQYICYVFQC ANESLVDEVM LTLKQAFSTA AALQSAKTQI KLCETCPMHS LHKLCERIEG LYPPRAKLVI QRHLSSLTDN EQADIFERVQ KMKPISDQEE NELVILHLRQ LCEAKQRTHV HIGEGPAIIS NSTIPENVTS GGRFKLDVLK NKAKRSLTSS LENIFSRGAN RMRGRLGSMD SFERANSLAS EKDFSPGDSP PGTPPASPLS SAWHAFPEED SDSPQFRRRA HTFSHPPSSS RRKLNLQDGK AHGLRSPLLR QSSSEQCSDG EGRKRTSSTC SNESLNAGGT PVTPRRVSWR QRIFLRVASP VNKSPSAMQQ QKDGLDRTEL LPLSPLSPTM EEEPLIIFLS GDEDTEKVEE KKKSKELKSL WKKAIHQQIL LLRMEKENQK LEEARRDELQ SRKVKLDYEE VGTCQKEILI AWDKKLLNCR TKIRCDMEDI HTSLKEGVPK SRRGEIWQFL ALQYRLRHRL PNKHQPPDTS YKELLKQLTA QQHAILVDLG RTFPTHPYFS VQLGAGQLSL FNLLKAYSLL DKEVGYCQGI SFVAGVLLLH MSEEQAFEML KFLMYDLGFR KQYRPDMMSL QIQMYQLSRL LHDYHRELYN HLEENEISPS LYAAPWFLTL FASQFPLGFV ARVFDIIFLQ GTEVIFKVAL SLLSSQEALI MECENFENIV EFLKSTLPDM NTTEMEKIIT QVFEMDISKQ LHAYEVEYHV LQDELLESSY ACEDNESLEK LERANNQLKR QNMDLLEKLQ VAHAKIQALE SNLETLLTRE TKMKALIRTL EQDKMAYQKT VEQIRKLLPA DALANCELLL KDLTHPTNDK AKAGNKP //