ID F6QTY0_MOUSE Unreviewed; 119 AA. AC F6QTY0; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 05-DEC-2018, entry version 47. DE SubName: Full=Trans-acting T-cell-specific transcription factor GATA-3 {ECO:0000313|Ensembl:ENSMUSP00000119730}; DE Flags: Fragment; GN Name=Gata3 {ECO:0000313|Ensembl:ENSMUSP00000119730, GN ECO:0000313|MGI:MGI:95663}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000119730, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000119730, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119730, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000119730} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000119730}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL845529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL928704; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PRIDE; F6QTY0; -. DR Ensembl; ENSMUST00000130615; ENSMUSP00000119730; ENSMUSG00000015619. DR MGI; MGI:95663; Gata3. DR eggNOG; KOG1601; Eukaryota. DR eggNOG; COG5641; LUCA. DR GeneTree; ENSGT00940000159247; -. DR OMA; RWMSHHP; -. DR Proteomes; UP000000589; Chromosome 2. DR Bgee; ENSMUSG00000015619; Expressed in 265 organ(s), highest expression level in embryo. DR ExpressionAtlas; F6QTY0; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:Ensembl. DR GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl. DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl. DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl. DR GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl. DR GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl. DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0003180; P:aortic valve morphogenesis; IEA:Ensembl. DR GO; GO:0007411; P:axon guidance; IEA:Ensembl. DR GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; IEA:Ensembl. DR GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Ensembl. DR GO; GO:0001709; P:cell fate determination; IEA:Ensembl. DR GO; GO:0048469; P:cell maturation; IEA:Ensembl. DR GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl. DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl. DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl. DR GO; GO:0048589; P:developmental growth; IEA:Ensembl. DR GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl. DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl. DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl. DR GO; GO:0072643; P:interferon-gamma secretion; IEA:Ensembl. DR GO; GO:0072602; P:interleukin-4 secretion; IEA:Ensembl. DR GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl. DR GO; GO:0008584; P:male gonad development; IEA:Ensembl. DR GO; GO:0060374; P:mast cell differentiation; IEA:Ensembl. DR GO; GO:0045786; P:negative regulation of cell cycle; IEA:Ensembl. DR GO; GO:2000607; P:negative regulation of cell proliferation involved in mesonephros development; IEA:Ensembl. DR GO; GO:1901536; P:negative regulation of DNA demethylation; IEA:Ensembl. DR GO; GO:2000703; P:negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl. DR GO; GO:2000734; P:negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; IEA:Ensembl. DR GO; GO:0032689; P:negative regulation of interferon-gamma production; IEA:Ensembl. DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0072179; P:nephric duct formation; IEA:Ensembl. DR GO; GO:0001764; P:neuron migration; IEA:Ensembl. DR GO; GO:0042421; P:norepinephrine biosynthetic process; IEA:Ensembl. DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl. DR GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl. DR GO; GO:0035898; P:parathyroid hormone secretion; IEA:Ensembl. DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl. DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl. DR GO; GO:0071442; P:positive regulation of histone H3-K14 acetylation; IEA:Ensembl. DR GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IEA:Ensembl. DR GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; IEA:Ensembl. DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl. DR GO; GO:2000553; P:positive regulation of T-helper 2 cell cytokine production; IEA:Ensembl. DR GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl. DR GO; GO:0072107; P:positive regulation of ureteric bud formation; IEA:Ensembl. DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl. DR GO; GO:0002572; P:pro-T cell differentiation; IEA:Ensembl. DR GO; GO:0043370; P:regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl. DR GO; GO:0042035; P:regulation of cytokine biosynthetic process; IEA:Ensembl. DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl. DR GO; GO:0061085; P:regulation of histone H3-K27 methylation; IEA:Ensembl. DR GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Ensembl. DR GO; GO:0072182; P:regulation of nephron tubule epithelial cell differentiation; IEA:Ensembl. DR GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl. DR GO; GO:0010975; P:regulation of neuron projection development; IEA:Ensembl. DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl. DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl. DR GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl. DR GO; GO:0045061; P:thymic T cell selection; IEA:Ensembl. DR GO; GO:0048538; P:thymus development; IEA:Ensembl. DR GO; GO:0031929; P:TOR signaling; IEA:Ensembl. DR GO; GO:0035799; P:ureter maturation; IEA:Ensembl. DR GO; GO:0060676; P:ureteric bud formation; IEA:Ensembl. DR GO; GO:0060065; P:uterus development; IEA:Ensembl. DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl. DR InterPro; IPR029521; GATA-3. DR InterPro; IPR039355; Transcription_factor_GATA. DR PANTHER; PTHR10071; PTHR10071; 1. DR PANTHER; PTHR10071:SF106; PTHR10071:SF106; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|EPD:F6QTY0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT NON_TER 119 119 {ECO:0000313|Ensembl:ENSMUSP00000119730}. SQ SEQUENCE 119 AA; 12788 MW; B8092CD276F01BDF CRC64; MEAQYPLTEE VDVLFNIDGQ GNHVPSYYGN SVRATVQRYP PTHHGSQVCR PPLLHGSLPW LDGGKALSSH HTASPWNLSP FSKTSIHHGS PGPLSVYPPA SSSSLAAGHS SPHLFTFPP //