ID F6N686_SHEEP Unreviewed; 422 AA. AC F6N686; A0A6P3CXD4; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 14-DEC-2022, entry version 33. DE RecName: Full=Vasopressin V1b receptor {ECO:0000256|RuleBase:RU046427}; OS Ovis aries (Sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=9940 {ECO:0000313|EMBL:AEG42503.1}; RN [1] {ECO:0000313|EMBL:AEG42503.1} RP NUCLEOTIDE SEQUENCE. RA Thompson D.J., Tariga H., Alagarsamy S., Vezza Alexander R., Croston G.E.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this CC receptor is mediated by G proteins which activate a phosphatidyl- CC inositol-calcium second messenger system. CC {ECO:0000256|RuleBase:RU046427}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Vasopressin/oxytocin receptor subfamily. CC {ECO:0000256|RuleBase:RU046427}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF940513; AEG42503.1; -; mRNA. DR RefSeq; NP_001233166.1; NM_001246237.1. DR AlphaFoldDB; F6N686; -. DR GeneID; 443050; -. DR KEGG; oas:443050; -. DR CTD; 553; -. DR OrthoDB; 890925at2759; -. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR015076; V1R_C. DR InterPro; IPR001817; Vasoprsn_rcpt. DR InterPro; IPR000628; Vprs_rcpt_V1B. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00896; VASOPRESSINR. DR PRINTS; PR00897; VASOPRSNV1BR. DR SMART; SM01164; DUF1856; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU046427}; KW Glycoprotein {ECO:0000256|RuleBase:RU046427}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU046427}; KW Receptor {ECO:0000256|RuleBase:RU046427, ECO:0000313|EMBL:AEG42503.1}; KW Transducer {ECO:0000256|RuleBase:RU046427}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU046427}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU046427}. FT TRANSMEM 38..59 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 71..89 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 109..130 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 151..174 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 199..222 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 284..306 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" FT TRANSMEM 318..341 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU046427" SQ SEQUENCE 422 AA; 46449 MW; 9BEECC20E323DFF0 CRC64; MDSRPPWTAA PTSGSTVAAA NATTPWLGRD EELARVEIGV LATVLALATG GNLTVLLTVG QPVRKRSRMQ VFVLHLALTD LGVALFQVLP QLLWDITYRF RGPDPLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPSRST YPLIAAPWLL AAVLSLPQVF IFSLREVIQG SGVLDCWADF RFPWGPRAYI TWTTLAIFIL PVAMLTACYS LICHEICKNL KVKTEAGQAE GGSWALRTGH LLSCPVAATR GLPSRVSSVS TISRAKIRTV KMTFVIVLAY IACWAPFFSV QMWSVWDENA PDEDSTNVAF TISMLLGNLS SCCNPWIYMG FNSHLWWRAL RRLACCRGAG PRMRRRLSNG SLSSRHATLL TRSSGLPARG LSPGLSRKPG PRDSLRGTEQ VDGDAATETS IF //