ID F6MDI0_HUMAN Unreviewed; 326 AA. AC F6MDI0; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 29-MAY-2024, entry version 59. DE SubName: Full=BRCA1 associated RING domain 1 isoform phi {ECO:0000313|EMBL:AEF57474.1}; GN Name=BARD1 {ECO:0000313|EMBL:AEF57474.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AEF57474.1}; RN [1] {ECO:0000313|EMBL:AEF57474.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18089818; DOI=10.1158/0008-5472.CAN-07-2370; RA Li L., Ryser S., Dizin E., Pils D., Krainer M., Jefford C.E., Bertoni F., RA Zeillinger R., Irminger-Finger I.; RT "Oncogenic BARD1 isoforms expressed in gynecological cancers."; RL Cancer Res. 67:11876-11885(2007). RN [2] {ECO:0000313|EMBL:AEF57474.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17556008; DOI=10.1016/j.biocel.2007.04.018; RA Li L., Cohen M., Wu J., Sow M.H., Nikolic B., Bischof P., RA Irminger-Finger I.; RT "Identification of BARD1 splice-isoforms involved in human trophoblast RT invasion."; RL Int. J. Biochem. Cell Biol. 39:1659-1672(2007). RN [3] {ECO:0000313|EMBL:AEF57474.1} RP NUCLEOTIDE SEQUENCE. RA Irminger-Finger I.; RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF790283; AEF57474.1; -; mRNA. DR RefSeq; NP_001269474.1; NM_001282545.1. DR AlphaFoldDB; F6MDI0; -. DR MaxQB; F6MDI0; -. DR PeptideAtlas; F6MDI0; -. DR DNASU; 580; -. DR GeneID; 580; -. DR CTD; 580; -. DR DisGeNET; 580; -. DR OrthoDB; 2478587at2759; -. DR BioGRID-ORCS; 580; 517 hits in 1215 CRISPR screens. DR ChiTaRS; BARD1; human. DR GenomeRNAi; 580; -. DR GO; GO:0070531; C:BRCA1-A complex; IEA:TreeGrafter. DR GO; GO:0031436; C:BRCA1-BARD1 complex; IEA:TreeGrafter. DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:TreeGrafter. DR GO; GO:0085020; P:protein K6-linked ubiquitination; IEA:TreeGrafter. DR CDD; cd17734; BRCT_Bard1_rpt1; 1. DR CDD; cd17720; BRCT_Bard1_rpt2; 1. DR Gene3D; 3.40.50.10190; BRCT domain; 2. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1. DR InterPro; IPR039503; BARD1_Znf-RING. DR InterPro; IPR001357; BRCT_dom. DR InterPro; IPR036420; BRCT_dom_sf. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1. DR PANTHER; PTHR24171:SF8; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1. DR Pfam; PF00533; BRCT; 1. DR Pfam; PF14835; zf-RING_6; 1. DR SMART; SM00292; BRCT; 2. DR SUPFAM; SSF52113; BRCT domain; 2. DR SUPFAM; SSF57850; RING/U-box; 1. DR PROSITE; PS50172; BRCT; 2. PE 2: Evidence at transcript level; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043}. FT DOMAIN 119..202 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT DOMAIN 216..326 FT /note="BRCT" FT /evidence="ECO:0000259|PROSITE:PS50172" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..15 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 326 AA; 37122 MW; 725F94B43488BDCC CRC64; MPDNRQPRNR QPRIRSGNEP RSASAMEPDG RGAWAHSRAA LDRLEKLLRC SRCTNILREP VCLGGCEHIF CSNIFGLRPV DYTDDESMKS LLLLPEKNES SSASHCSVMN TGQRRDGPLV LIGSGLSSEQ QKMLSELAVI LKAKKYTEFD STVTHVVVPG DAVQSTLKCM LGILNGCWIL KFEWVKACLR RKVCEQEEKY EIPEGPRRSR LNREQLLPKL FDGCYFYLWG TFKHHPKDNL IKLVTAGGGQ ILSRKPKPDS DVTQTINTVA YHARPDSDQR FCTQYIIYED LCNYHPERVR QGKVWKAPSS WFIDCVMSFE LLPLDS //