ID F6LXD2_9HIV1 Unreviewed; 192 AA. AC F6LXD2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 18-JUL-2018, entry version 30. DE RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341}; GN Name=vif {ECO:0000313|EMBL:AEG75741.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEG75741.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AEG75741.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=449-B282 {ECO:0000313|EMBL:AEG75741.1}; RX PubMed=21571098; DOI=10.1016/j.meegid.2011.04.020; RA De Maio F.A., Rocco C.A., Aulicino P.C., Bologna R., Mangano A., RA Sen L.; RT "Effect of HIV-1 Vif variability on progression to pediatric AIDS and RT its association with APOBEC3G and CUL5 polymorphisms."; RL Infect. Genet. Evol. 11:1256-1262(2011). CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}; CC Peripheral membrane protein {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059686}; Cytoplasmic side CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059686}. CC Host cytoplasm {ECO:0000256|RuleBase:RU003341}. Virion CC {ECO:0000256|RuleBase:RU003341, ECO:0000256|SAAS:SAAS01059682}. CC Note=In the cytoplasm, seems to colocalize with intermediate CC filament vimentin. A fraction is associated with the cytoplasmic CC side of cellular membranes, presumably via the interaction with CC Pr55Gag precursor. {ECO:0000256|RuleBase:RU003341}. CC -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein CC family. {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS01059764}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF494993; AEG75741.1; -; Genomic_DNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0019058; P:viral life cycle; IEA:InterPro. DR HAMAP; MF_04081; HIV_VIF; 1. DR InterPro; IPR000475; Viral_infect. DR Pfam; PF00559; Vif; 1. DR PRINTS; PR00349; VIRIONINFFCT. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS01059755}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS01059745}; KW Host membrane {ECO:0000256|SAAS:SAAS01059757}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01059733}; KW Membrane {ECO:0000256|SAAS:SAAS01059748}; KW Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01059744}; KW Virion {ECO:0000256|SAAS:SAAS01059762}. SQ SEQUENCE 192 AA; 22673 MW; A856C22DF7C7587B CRC64; MENRWQVMIV WQVDRMRINT WKSLVKYHMH ISKKAKRWSY KHHFESRNPR VSSEVHIPLE EAKVVITTYW GLHTGERDWH LGQGVSIEWR QGRYRTQIDP GLADQLIHIY YFDCFSESAI RRAILGHKIS PRCNYQAGHN KVGSLQYLAL TALIAPKKTK PPLPSVKKLV EDRWNKPQET RGRRGNHTMN GH //