ID F6LXD2_9HIV1 Unreviewed; 192 AA. AC F6LXD2; DT 27-JUL-2011, integrated into UniProtKB/TrEMBL. DT 27-JUL-2011, sequence version 1. DT 22-NOV-2017, entry version 23. DE RecName: Full=Virion infectivity factor {ECO:0000256|RuleBase:RU003341}; GN Name=vif {ECO:0000313|EMBL:AEG75741.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AEG75741.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AEG75741.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=449-B282 {ECO:0000313|EMBL:AEG75741.1}; RX PubMed=21571098; DOI=10.1016/j.meegid.2011.04.020; RA De Maio F.A., Rocco C.A., Aulicino P.C., Bologna R., Mangano A., RA Sen L.; RT "Effect of HIV-1 Vif variability on progression to pediatric AIDS and RT its association with APOBEC3G and CUL5 polymorphisms."; RL Infect. Genet. Evol. 11:1256-1262(2011). CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00594051}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00594051}; Cytoplasmic side CC {ECO:0000256|SAAS:SAAS00594051}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000256|RuleBase:RU003341}. Host cell membrane CC {ECO:0000256|RuleBase:RU003341}; Peripheral membrane protein CC {ECO:0000256|RuleBase:RU003341}; Cytoplasmic side CC {ECO:0000256|RuleBase:RU003341}. Virion CC {ECO:0000256|RuleBase:RU003341}. Note=In the cytoplasm, seems to CC colocalize with intermediate filament vimentin. A fraction is CC associated with the cytoplasmic side of cellular membranes, CC presumably via the interaction with Pr55Gag precursor. CC {ECO:0000256|RuleBase:RU003341}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|SAAS:SAAS00594062}. CC -!- SIMILARITY: Belongs to the primate lentivirus group Vif protein CC family. {ECO:0000256|RuleBase:RU003341, CC ECO:0000256|SAAS:SAAS00594061}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JF494993; AEG75741.1; -; Genomic_DNA. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0019058; P:viral life cycle; IEA:InterPro. DR InterPro; IPR000475; Viral_infect. DR Pfam; PF00559; Vif; 1. DR PRINTS; PR00349; VIRIONINFFCT. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|SAAS:SAAS00135760}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS00487388}; KW Host membrane {ECO:0000256|SAAS:SAAS00487340}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00487339}; KW Membrane {ECO:0000256|SAAS:SAAS00135657}; KW Ubl conjugation pathway {ECO:0000256|SAAS:SAAS00487332}; KW Virion {ECO:0000256|SAAS:SAAS00487311}. SQ SEQUENCE 192 AA; 22673 MW; A856C22DF7C7587B CRC64; MENRWQVMIV WQVDRMRINT WKSLVKYHMH ISKKAKRWSY KHHFESRNPR VSSEVHIPLE EAKVVITTYW GLHTGERDWH LGQGVSIEWR QGRYRTQIDP GLADQLIHIY YFDCFSESAI RRAILGHKIS PRCNYQAGHN KVGSLQYLAL TALIAPKKTK PPLPSVKKLV EDRWNKPQET RGRRGNHTMN GH //