ID GL_HHV8P Reviewed; 167 AA. AC F5HDB7; DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 13-NOV-2013, entry version 8. DE RecName: Full=Envelope glycoprotein L; DE Flags: Precursor; GN Name=gL; ORFNames=47; OS Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's OS sarcoma-associated herpesvirus). OC Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae; OC Gammaherpesvirinae; Rhadinovirus. OX NCBI_TaxID=868565; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10400794; RA Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.; RT "Identification of a spliced gene from Kaposi's sarcoma-associated RT herpesvirus encoding a protein with similarities to latent membrane RT proteins 1 and 2A of Epstein-Barr virus."; RL J. Virol. 73:6953-6963(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16760382; DOI=10.1099/vir.0.81919-0; RA Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.; RT "Kaposi's sarcoma-associated herpesvirus immune modulation: an RT overview."; RL J. Gen. Virol. 87:1781-1804(2006). RN [3] RP FUNCTION. RX PubMed=11932406; DOI=10.1128/JVI.76.9.4390-4400.2002; RA Pertel P.E.; RT "Human herpesvirus 8 glycoprotein B (gB), gH, and gL can mediate cell RT fusion."; RL J. Virol. 76:4390-4400(2002). RN [4] RP FUNCTION, AND INTERACTION WITH GLYCOPROTEIN H. RX PubMed=18945775; DOI=10.1128/JVI.01170-08; RA Hahn A., Birkmann A., Wies E., Dorer D., Mahr K., Sturzl M., RA Titgemeyer F., Neipel F.; RT "Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export RT and interaction with cellular receptors."; RL J. Virol. 83:396-407(2009). RN [5] RP FUNCTION, AND INTERACTION WITH HOST EPHA2. RX PubMed=22635007; DOI=10.1038/nm.2805; RA Hahn A.S., Kaufmann J.K., Wies E., Naschberger E., Panteleev-Ivlev J., RA Schmidt K., Holzer A., Schmidt M., Chen J., Konig S., Ensser A., RA Myoung J., Brockmeyer N.H., Sturzl M., Fleckenstein B., Neipel F.; RT "The ephrin receptor tyrosine kinase A2 is a cellular receptor for RT Kaposi's sarcoma-associated herpesvirus."; RL Nat. Med. 18:961-966(2012). CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is CC required for the fusion of viral and plasma membranes leading to CC virus entry into the host cell. Membrane fusion is mediated by the CC fusion machinery composed of at least gB and the heterodimer CC gH/gL. Targets heparan sulfate proteoglycans of the syndecan CC family as well as host EPHA2 to promote viral entry. CC -!- SUBUNIT: Interacts with glycoprotein H (gH). When in complex with CC gH, interacts with host EPHA2; this interaction triggers EPHA2 CC phosphorylation and endocytosis, allowing virus entry. CC -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane CC protein; Extracellular side (By similarity). Host cell membrane; CC Peripheral membrane protein; Extracellular side (By similarity). CC Note=gL is not anchored to the viral envelope, but associates with CC the extravirion surface through its binding to gH (By similarity). CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF148805; ABD28897.1; -; Genomic_DNA. DR RefSeq; YP_001129399.1; NC_009333.1. DR GeneID; 4961475; -. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019064; P:viral entry into host cell via membrane fusion with the plasma membrane; IEA:UniProtKB-KW. DR InterPro; IPR020175; Herpes_gL_rhadinovirus. DR Pfam; PF11108; Phage_glycop_gL; 1. DR ProDom; PD009419; Herpes_gL_rhadinovirus; 1. PE 1: Evidence at protein level; KW Complete proteome; Fusion of virus membrane with host cell membrane; KW Fusion of virus membrane with host membrane; Glycoprotein; KW Host cell membrane; Host membrane; Membrane; Reference proteome; KW Signal; Viral envelope protein; Viral penetration into host cytoplasm; KW Virion; Virus entry into host cell. FT SIGNAL 1 20 Potential. FT CHAIN 21 167 Envelope glycoprotein L. FT /FTId=PRO_0000423758. FT COMPBIAS 131 134 Poly-Ile. SQ SEQUENCE 167 AA; 17999 MW; F711D54C707A8106 CRC64; MGIFALFAVL WTTLLVTSHA YVALPCCAIQ ASAASTLPLF FAVHSIHFAD PNHCNGVCIA KLRSKTGDIT VETCVNGFNL RSFLVAVVRR LGSWASQENL RLLWYLQRSL TAYTVGFNAT TADSSIHNVN IIIISVGKAM NRTGSVSGSQ TRAKSSSRRA HAGQKGK //