ID GL_HHV8P Reviewed; 167 AA. AC F5HDB7; DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 03-JUL-2019, entry version 24. DE RecName: Full=Envelope glycoprotein L {ECO:0000255|HAMAP-Rule:MF_04034}; DE Short=gL {ECO:0000255|HAMAP-Rule:MF_04034}; DE Flags: Precursor; GN Name=gL {ECO:0000255|HAMAP-Rule:MF_04034}; ORFNames=47; OS Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's OS sarcoma-associated herpesvirus). OC Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; OC Rhadinovirus. OX NCBI_TaxID=868565; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=10400794; RA Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.; RT "Identification of a spliced gene from Kaposi's sarcoma-associated RT herpesvirus encoding a protein with similarities to latent membrane RT proteins 1 and 2A of Epstein-Barr virus."; RL J. Virol. 73:6953-6963(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16760382; DOI=10.1099/vir.0.81919-0; RA Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.; RT "Kaposi's sarcoma-associated herpesvirus immune modulation: an RT overview."; RL J. Gen. Virol. 87:1781-1804(2006). RN [3] RP FUNCTION. RX PubMed=11932406; DOI=10.1128/JVI.76.9.4390-4400.2002; RA Pertel P.E.; RT "Human herpesvirus 8 glycoprotein B (gB), gH, and gL can mediate cell RT fusion."; RL J. Virol. 76:4390-4400(2002). RN [4] RP FUNCTION, AND INTERACTION WITH GLYCOPROTEIN H. RX PubMed=18945775; DOI=10.1128/JVI.01170-08; RA Hahn A., Birkmann A., Wies E., Dorer D., Mahr K., Sturzl M., RA Titgemeyer F., Neipel F.; RT "Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export RT and interaction with cellular receptors."; RL J. Virol. 83:396-407(2009). RN [5] RP FUNCTION, AND INTERACTION WITH HOST EPHA2. RX PubMed=22635007; DOI=10.1038/nm.2805; RA Hahn A.S., Kaufmann J.K., Wies E., Naschberger E., Panteleev-Ivlev J., RA Schmidt K., Holzer A., Schmidt M., Chen J., Konig S., Ensser A., RA Myoung J., Brockmeyer N.H., Sturzl M., Fleckenstein B., Neipel F.; RT "The ephrin receptor tyrosine kinase A2 is a cellular receptor for RT Kaposi's sarcoma-associated herpesvirus."; RL Nat. Med. 18:961-966(2012). CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is CC required for the fusion of viral and plasma membranes leading to CC virus entry into the host cell. Acts as a functional inhibitor of CC gH and maintains gH in an inhibited form. Upon binding to host CC integrins, gL dissociates from gH leading to activation of the CC viral fusion glycoproteins gB and gH. Targets heparan sulfate CC proteoglycans of the syndecan family as well as host EPHA2 to CC promote viral entry. {ECO:0000255|HAMAP-Rule:MF_04034, CC ECO:0000269|PubMed:11932406, ECO:0000269|PubMed:18945775, CC ECO:0000269|PubMed:22635007}. CC -!- SUBUNIT: Interacts with glycoprotein H (gH); this interaction is CC necessary for the correct processing and cell surface expression CC of gH. The heterodimer gH/gL seems to interact with gB trimers CC during fusion. When in complex with gH, interacts with host EPHA2; CC this interaction triggers EPHA2 phosphorylation and endocytosis, CC allowing virus entry. {ECO:0000255|HAMAP-Rule:MF_04034, CC ECO:0000269|PubMed:18945775, ECO:0000269|PubMed:22635007}. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP- CC Rule:MF_04034}; Peripheral membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04034}; Extracellular side {ECO:0000255|HAMAP- CC Rule:MF_04034}. Host cell membrane {ECO:0000255|HAMAP- CC Rule:MF_04034}; Peripheral membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04034}; Extracellular side {ECO:0000255|HAMAP- CC Rule:MF_04034}. Host Golgi apparatus, host trans-Golgi network CC {ECO:0000255|HAMAP-Rule:MF_04034}. Note=gL associates with the CC extravirion surface through its binding to gH. During virion CC morphogenesis, this protein probably accumulates in the host CC trans-Golgi where secondary envelopment occurs. CC {ECO:0000255|HAMAP-Rule:MF_04034}. CC -!- SIMILARITY: Belongs to the herpesviridae glycoprotein L family. CC {ECO:0000255|HAMAP-Rule:MF_04034}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF148805; ABD28897.1; -; Genomic_DNA. DR RefSeq; YP_001129399.1; NC_009333.1. DR BioGrid; 1776978; 18. DR PRIDE; F5HDB7; -. DR GeneID; 4961475; -. DR KEGG; vg:4961475; -. DR Proteomes; UP000000942; Genome. DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.120.1580; -; 1. DR HAMAP; MF_04034; HSV_GL_alphagamma; 1. DR InterPro; IPR020175; Herpes_gL_rhadinovirus. DR InterPro; IPR038313; Herpes_gL_rhadinovirus_sf. DR InterPro; IPR034708; HSV_GL_alphagamma. DR Pfam; PF11108; Phage_glycop_gL; 1. PE 1: Evidence at protein level; KW Complete proteome; Fusion of virus membrane with host cell membrane; KW Fusion of virus membrane with host membrane; Glycoprotein; KW Host cell membrane; Host Golgi apparatus; Host membrane; Membrane; KW Reference proteome; Signal; Viral envelope protein; KW Viral penetration into host cytoplasm; Virion; KW Virus entry into host cell. FT SIGNAL 1 20 {ECO:0000255|HAMAP-Rule:MF_04034}. FT CHAIN 21 167 Envelope glycoprotein L. FT {ECO:0000255|HAMAP-Rule:MF_04034}. FT /FTId=PRO_0000423758. FT REGION 18 131 Interaction with gH. {ECO:0000255|HAMAP- FT Rule:MF_04034}. FT COMPBIAS 131 134 Poly-Ile. SQ SEQUENCE 167 AA; 17999 MW; F711D54C707A8106 CRC64; MGIFALFAVL WTTLLVTSHA YVALPCCAIQ ASAASTLPLF FAVHSIHFAD PNHCNGVCIA KLRSKTGDIT VETCVNGFNL RSFLVAVVRR LGSWASQENL RLLWYLQRSL TAYTVGFNAT TADSSIHNVN IIIISVGKAM NRTGSVSGSQ TRAKSSSRRA HAGQKGK //