ID F5H852_HUMAN Unreviewed; 164 AA. AC F5H852; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 27-MAR-2024, entry version 73. DE SubName: Full=Fatty acid desaturase 1 {ECO:0000313|Ensembl:ENSP00000442170.1}; DE Flags: Fragment; GN Name=FADS1 {ECO:0000313|Ensembl:ENSP00000442170.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442170.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000442170.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16554811; DOI=10.1038/nature04632; RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T., RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C., RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., RA Hattori M., Rogers J., Lander E.S., Sakaki Y.; RT "Human chromosome 11 DNA sequence and analysis including novel gene RT identification."; RL Nature 440:497-500(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000442170.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP002380; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; F5H852; -. DR SMR; F5H852; -. DR MassIVE; F5H852; -. DR MaxQB; F5H852; -. DR PeptideAtlas; F5H852; -. DR ProteomicsDB; 27684; -. DR Antibodypedia; 21596; 304 antibodies from 36 providers. DR Ensembl; ENST00000545245.5; ENSP00000442170.1; ENSG00000149485.19. DR UCSC; uc058ces.1; human. DR HGNC; HGNC:3574; FADS1. DR VEuPathDB; HostDB:ENSG00000149485; -. DR GeneTree; ENSGT00950000182990; -. DR OMA; LYNCNYF; -. DR ChiTaRS; FADS1; human. DR Proteomes; UP000005640; Chromosome 11. DR Bgee; ENSG00000149485; Expressed in upper leg skin and 205 other cell types or tissues. DR ExpressionAtlas; F5H852; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. DR InterPro; IPR005804; FA_desaturase_dom. DR InterPro; IPR012171; Fatty_acid_desaturase. DR PANTHER; PTHR19353:SF57; ACYL-COA (8-3)-DESATURASE; 1. DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1. DR Pfam; PF00487; FA_desaturase; 1. PE 1: Evidence at protein level; KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:F5H852, KW ECO:0007829|MaxQB:F5H852}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 46..67 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 72..152 FT /note="Fatty acid desaturase" FT /evidence="ECO:0000259|Pfam:PF00487" FT NON_TER 164 FT /evidence="ECO:0000313|Ensembl:ENSP00000442170.1" SQ SEQUENCE 164 AA; 18884 MW; F9ADA85D17733BCB CRC64; MNSLLIGELS PEQPSFEPTK NKELTDEFRE LRATVERMGL MKANHVFFLL YLLHILLLDG AAWLTLWVFG TSFLPFLLCA VLLSAVQAQA GWLQHDFGHL SVFSTSKWNH LLHHFVIGHL KGAPASWWNH MHFQHHAKPN CFRKDPDINM HPFFFALGKI LSVE //