ID   F5H852_HUMAN            Unreviewed;       164 AA.
AC   F5H852;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   28-JUN-2023, entry version 69.
DE   SubName: Full=Fatty acid desaturase 1 {ECO:0000313|Ensembl:ENSP00000442170.1};
DE   Flags: Fragment;
GN   Name=FADS1 {ECO:0000313|Ensembl:ENSP00000442170.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442170.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000442170.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000442170.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AP002380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F5H852; -.
DR   SMR; F5H852; -.
DR   MaxQB; F5H852; -.
DR   PeptideAtlas; F5H852; -.
DR   ProteomicsDB; 27684; -.
DR   Antibodypedia; 21596; 296 antibodies from 36 providers.
DR   Ensembl; ENST00000545245.5; ENSP00000442170.1; ENSG00000149485.19.
DR   UCSC; uc058ces.1; human.
DR   HGNC; HGNC:3574; FADS1.
DR   VEuPathDB; HostDB:ENSG00000149485; -.
DR   GeneTree; ENSGT00950000182990; -.
DR   OMA; LYNCNYF; -.
DR   ChiTaRS; FADS1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149485; Expressed in upper leg skin and 203 other tissues.
DR   ExpressionAtlas; F5H852; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR19353:SF57; ACYL-COA (8-3)-DESATURASE; 1.
DR   PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   1: Evidence at protein level;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:F5H852,
KW   ECO:0007829|MaxQB:F5H852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..151
FT                   /note="Fatty acid desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
FT   NON_TER         164
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000442170.1"
SQ   SEQUENCE   164 AA;  18884 MW;  F9ADA85D17733BCB CRC64;
     MNSLLIGELS PEQPSFEPTK NKELTDEFRE LRATVERMGL MKANHVFFLL YLLHILLLDG
     AAWLTLWVFG TSFLPFLLCA VLLSAVQAQA GWLQHDFGHL SVFSTSKWNH LLHHFVIGHL
     KGAPASWWNH MHFQHHAKPN CFRKDPDINM HPFFFALGKI LSVE
//