ID   F5H852_HUMAN            Unreviewed;       164 AA.
AC   F5H852;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   12-OCT-2022, entry version 65.
DE   SubName: Full=Acyl-CoA (8-3)-desaturase {ECO:0000313|Ensembl:ENSP00000442170};
DE   Flags: Fragment;
GN   Name=FADS1 {ECO:0000313|Ensembl:ENSP00000442170};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442170, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000442170, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000442170}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC       {ECO:0000256|ARBA:ARBA00009295}.
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DR   EMBL; AP002380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; F5H852; -.
DR   MaxQB; F5H852; -.
DR   PeptideAtlas; F5H852; -.
DR   ProteomicsDB; 27684; -.
DR   Antibodypedia; 21596; 277 antibodies from 35 providers.
DR   Ensembl; ENST00000545245.5; ENSP00000442170.1; ENSG00000149485.19.
DR   UCSC; uc058ces.1; human.
DR   HGNC; HGNC:3574; FADS1.
DR   VEuPathDB; HostDB:ENSG00000149485; -.
DR   GeneTree; ENSGT00950000182990; -.
DR   OMA; MITFYIR; -.
DR   ChiTaRS; FADS1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149485; Expressed in upper leg skin and 203 other tissues.
DR   ExpressionAtlas; F5H852; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR19353; PTHR19353; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   1: Evidence at protein level;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Proteomics identification {ECO:0007829|EPD:F5H852,
KW   ECO:0007829|MaxQB:F5H852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..151
FT                   /note="FA_desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
FT   NON_TER         164
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000442170"
SQ   SEQUENCE   164 AA;  18884 MW;  F9ADA85D17733BCB CRC64;
     MNSLLIGELS PEQPSFEPTK NKELTDEFRE LRATVERMGL MKANHVFFLL YLLHILLLDG
     AAWLTLWVFG TSFLPFLLCA VLLSAVQAQA GWLQHDFGHL SVFSTSKWNH LLHHFVIGHL
     KGAPASWWNH MHFQHHAKPN CFRKDPDINM HPFFFALGKI LSVE
//