ID   F5H852_HUMAN            Unreviewed;       164 AA.
AC   F5H852;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   11-DEC-2019, entry version 52.
DE   SubName: Full=Acyl-CoA (8-3)-desaturase {ECO:0000313|Ensembl:ENSP00000442170};
DE   Flags: Fragment;
GN   Name=FADS1 {ECO:0000313|Ensembl:ENSP00000442170};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000442170, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000442170, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000442170}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AP002380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; F5H852; -.
DR   MaxQB; F5H852; -.
DR   PeptideAtlas; F5H852; -.
DR   PRIDE; F5H852; -.
DR   ProteomicsDB; 27684; -.
DR   Ensembl; ENST00000545245; ENSP00000442170; ENSG00000149485.
DR   UCSC; uc058ces.1; human.
DR   EuPathDB; HostDB:ENSG00000149485.16; -.
DR   HGNC; HGNC:3574; FADS1.
DR   OpenTargets; ENSG00000149485; -.
DR   eggNOG; KOG4232; Eukaryota.
DR   eggNOG; ENOG410XVSZ; LUCA.
DR   GeneTree; ENSGT00950000182990; -.
DR   ChiTaRS; FADS1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149485; Expressed in 232 organ(s), highest expression level in mammalian vulva.
DR   ExpressionAtlas; F5H852; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:F5H852,
KW   ECO:0000213|MaxQB:F5H852, ECO:0000213|PeptideAtlas:F5H852,
KW   ECO:0000213|ProteomicsDB:F5H852};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        46..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          72..151
FT                   /note="FA_desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
FT   NON_TER         164
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000442170"
SQ   SEQUENCE   164 AA;  18884 MW;  F9ADA85D17733BCB CRC64;
     MNSLLIGELS PEQPSFEPTK NKELTDEFRE LRATVERMGL MKANHVFFLL YLLHILLLDG
     AAWLTLWVFG TSFLPFLLCA VLLSAVQAQA GWLQHDFGHL SVFSTSKWNH LLHHFVIGHL
     KGAPASWWNH MHFQHHAKPN CFRKDPDINM HPFFFALGKI LSVE
//