ID F5H4D1_HUMAN Unreviewed; 734 AA. AC F5H4D1; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 10-MAY-2017, entry version 48. DE SubName: Full=Adenylate cyclase type 7 {ECO:0000313|Ensembl:ENSP00000457409}; GN Name=ADCY7 {ECO:0000313|Ensembl:ENSP00000457409}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000457409, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000457409, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000457409} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000457409}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC007597; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456186; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001272986.1; NM_001286057.1. DR RefSeq; NP_001272986.1; NM_001286057.1. DR RefSeq; NP_001272986.1; NM_001286057.1. DR RefSeq; XP_016878387.1; XM_017022898.1. DR RefSeq; XP_016878387.1; XM_017022898.1. DR RefSeq; XP_016878387.1; XM_017022898.1. DR UniGene; Hs.513578; -. DR ProteinModelPortal; F5H4D1; -. DR STRING; 9606.ENSP00000254235; -. DR MaxQB; F5H4D1; -. DR PaxDb; F5H4D1; -. DR PeptideAtlas; F5H4D1; -. DR PRIDE; F5H4D1; -. DR Ensembl; ENST00000566433; ENSP00000457409; ENSG00000121281. DR GeneID; 113; -. DR UCSC; uc002egb.3; human. DR CTD; 113; -. DR HGNC; HGNC:238; ADCY7. DR OpenTargets; ENSG00000121281; -. DR eggNOG; KOG3619; Eukaryota. DR eggNOG; COG2114; LUCA. DR GeneTree; ENSGT00760000119042; -. DR GenomeRNAi; 113; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000121281; -. DR ExpressionAtlas; F5H4D1; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005886; C:plasma membrane; IEA:InterPro. DR GO; GO:0004016; F:adenylate cyclase activity; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR Gene3D; 3.30.70.1230; -; 1. DR InterPro; IPR001054; A/G_cyclase. DR InterPro; IPR032628; AC_N. DR InterPro; IPR009398; Adcy_conserved_dom. DR InterPro; IPR029787; Nucleotide_cyclase. DR Pfam; PF16214; AC_N; 1. DR Pfam; PF06327; DUF1053; 1. DR Pfam; PF00211; Guanylate_cyc; 1. DR SMART; SM00044; CYCc; 1. DR SUPFAM; SSF55073; SSF55073; 1. DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:F5H4D1, KW ECO:0000213|PeptideAtlas:F5H4D1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 34 53 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 65 85 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 92 116 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 122 140 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 147 170 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 176 196 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 597 614 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 620 641 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 666 689 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 279 406 Guanylate cyclase. {ECO:0000259|PROSITE: FT PS50125}. SQ SEQUENCE 734 AA; 81478 MW; F2FA68E3C5F2E504 CRC64; MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP HLHTVFSRLN ELTS //