ID   F5H2D7_HUMAN            Unreviewed;       166 AA.
AC   F5H2D7;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   05-JUN-2019, entry version 49.
DE   SubName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 {ECO:0000313|Ensembl:ENSP00000438629};
DE   Flags: Fragment;
GN   Name=PLCZ1 {ECO:0000313|Ensembl:ENSP00000438629};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000438629, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000438629, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RG   Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
RA   Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D.,
RA   Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
RA   Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
RA   Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
RA   Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V.,
RA   Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J.,
RA   Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
RA   Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
RA   Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
RA   Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
RA   Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
RA   Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
RA   Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
RA   Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
RA   Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
RA   Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
RA   Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
RA   Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
RA   Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
RA   Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
RA   Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
RA   Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
RA   Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
RA   Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
RA   Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
RA   Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
RA   Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
RA   Kucherlapati R., Weinstock G., Gibbs R.A., null.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000438629}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AC087242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; F5H2D7; -.
DR   PRIDE; F5H2D7; -.
DR   Ensembl; ENST00000539072; ENSP00000438629; ENSG00000139151.
DR   UCSC; uc058lrz.1; human.
DR   HGNC; HGNC:19218; PLCZ1.
DR   OpenTargets; ENSG00000139151; -.
DR   GeneTree; ENSGT00940000159950; -.
DR   ChiTaRS; PLCZ1; human.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000139151; Expressed in 60 organ(s), highest expression level in sperm.
DR   ExpressionAtlas; F5H2D7; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0004629; F:phospholipase C activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IEA:InterPro.
DR   GO; GO:0007343; P:egg activation; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR028395; PLC-zeta1.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   PANTHER; PTHR10336; PTHR10336; 2.
DR   PANTHER; PTHR10336:SF29; PTHR10336:SF29; 2.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:F5H2D7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN        1    126       PLCXc. {ECO:0000259|SMART:SM00148}.
FT   REGION      132    157       Disordered. {ECO:0000256|MobiDB-lite:
FT                                F5H2D7}.
FT   COMPBIAS    132    152       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                F5H2D7}.
FT   NON_TER     166    166       {ECO:0000313|Ensembl:ENSP00000438629}.
SQ   SEQUENCE   166 AA;  18922 MW;  F3C45DA42CB13F56 CRC64;
     MTAPTGERLL NSGLICSPFW KRELKQRGQI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV
     KQIFKTSDYP VVLSLENHCS TAQQEVMADN LQATFGESLL SDMLDDFPDT LPSPEALKFK
     ILVKNKKIGT LKETHERKGS DKRGDNQDKE TGVKKLPGVM LFKKKK
//