ID CONA1_LUPAN Reviewed; 506 AA. AC F5B8V6; Q96475; DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 11-DEC-2019, entry version 32. DE RecName: Full=Conglutin alpha 1 {ECO:0000303|PubMed:21457583}; DE AltName: Allergen=Lup an alpha-conglutin {ECO:0000305}; DE Contains: DE RecName: Full=Conglutin alpha 1A subunit {ECO:0000250|UniProtKB:P04347}; DE Contains: DE RecName: Full=Conglutin alpha 1B subunit {ECO:0000250|UniProtKB:P04347}; DE Flags: Precursor; GN Name=CONALPHA {ECO:0000303|PubMed:9247543}; GN ORFNames=TanjilG_28353 {ECO:0000312|EMBL:OIW11262.1}; OS Lupinus angustifolius (Narrow-leaved blue lupine). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade; OC genistoids sensu lato; core genistoids; Genisteae; Lupinus. OX NCBI_TaxID=3871; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND ALLERGEN. RC STRAIN=cv. Tanjil; TISSUE=Seed; RX PubMed=21457583; DOI=10.1186/1471-2229-11-59; RA Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E., Smith P.M.C., RA Atkins C.A., Singh K.B.; RT "Identification and characterisation of seed storage protein transcripts RT from Lupinus angustifolius."; RL BMC Plant Biol. 11:59-59(2011). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Tanjil; TISSUE=Seedling; RX PubMed=27557478; DOI=10.1111/pbi.12615; RA Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A., RA Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R., RA Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W., RA McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.; RT "A comprehensive draft genome sequence for lupin (Lupinus angustifolius), RT an emerging health food: insights into plant-microbe interactions and RT legume evolution."; RL Plant Biotechnol. J. 15:318-330(2017). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 267-397, TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RC STRAIN=cv. Unicrop; RX PubMed=9247543; DOI=10.1023/a:1005868105651; RA Ilgoutz S.C., Knittel N., Lin J.M., Sterle S., Gayler K.R.; RT "Transcription of genes for conglutin gamma and a leginsulin-like protein RT in narrow-leafed lupin."; RL Plant Mol. Biol. 34:613-627(1997). RN [4] RP SUBUNIT. RC STRAIN=cv. Zeus; RX PubMed=22264085; DOI=10.1021/jf2042592; RA Czubinski J., Dwiecki K., Siger A., Kachlicki P., Neunert G., RA Lampart-Szczapa E., Nogala-Kalucka M.; RT "Release of flavonoids from lupin globulin proteins during digestion in a RT model system."; RL J. Agric. Food Chem. 60:1830-1836(2012). CC -!- FUNCTION: Sulfur-rich seed storage protein. This protein found in the CC seeds of many leguminous and non-leguminous plants is the source of CC sulfur-containing amino acids in seed meals. CC {ECO:0000269|PubMed:21457583}. CC -!- SUBUNIT: Hexamer; each subunit is composed of an acidic and a basic CC chain derived from a single precursor and linked by a disulfide bond CC (By similarity). Component of globulins complexes which accumulate in CC seeds (Probable). {ECO:0000250|UniProtKB:P04347, CC ECO:0000305|PubMed:22264085}. CC -!- TISSUE SPECIFICITY: Expressed in developing cotyledons and in the CC embryonic axis of germinating seeds. {ECO:0000269|PubMed:9247543}. CC -!- DEVELOPMENTAL STAGE: Accumulates during seed development. CC {ECO:0000269|PubMed:21457583, ECO:0000269|PubMed:9247543}. CC -!- ALLERGEN: Causes an allergic reaction in human. CC {ECO:0000305|PubMed:21457583}. CC -!- SIMILARITY: Belongs to the 11S seed storage protein (globulins) family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ670406; AEB33709.1; -; mRNA. DR EMBL; CM007365; OIW11262.1; -; Genomic_DNA. DR EMBL; U74384; AAC49787.1; -; mRNA. DR Allergome; 7697; Lup an alpha_Conglutin. DR EnsemblPlants; OIW11262; OIW11262; TanjilG_28353. DR Gramene; OIW11262; OIW11262; TanjilG_28353. DR Proteomes; UP000188354; Chromosome LG05. DR Proteomes; UP000188354; Unassembled WGS sequence. DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW. DR Gene3D; 2.60.120.10; -; 3. DR InterPro; IPR022379; 11S_seedstore_CS. DR InterPro; IPR006044; 11S_seedstore_pln. DR InterPro; IPR006045; Cupin_1. DR InterPro; IPR014710; RmlC-like_jellyroll. DR InterPro; IPR011051; RmlC_Cupin_sf. DR Pfam; PF00190; Cupin_1; 2. DR PRINTS; PR00439; 11SGLOBULIN. DR SMART; SM00835; Cupin_1; 2. DR SUPFAM; SSF51182; SSF51182; 1. DR PROSITE; PS00305; 11S_SEED_STORAGE; 1. PE 1: Evidence at protein level; KW Allergen; Disulfide bond; Glycoprotein; Reference proteome; KW Seed storage protein; Signal; Storage protein. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT CHAIN 20..506 FT /note="Conglutin alpha 1" FT /id="PRO_5011015128" FT CHAIN 20..321 FT /note="Conglutin alpha 1A subunit" FT /evidence="ECO:0000250|UniProtKB:P04347" FT /id="PRO_0000446133" FT CHAIN 322..506 FT /note="Conglutin alpha 1B subunit" FT /evidence="ECO:0000250|UniProtKB:P04347" FT /id="PRO_0000446134" FT DOMAIN 36..235 FT /note="Cupin type-1 1" FT /evidence="ECO:0000255" FT DOMAIN 334..483 FT /note="Cupin type-1 2" FT /evidence="ECO:0000255" FT COMPBIAS 187..205 FT /note="Gln-rich" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00006" FT COMPBIAS 270..302 FT /note="Glu-rich" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00007" FT COMPBIAS 282..320 FT /note="Arg-rich" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00002" FT COMPBIAS 289..316 FT /note="His-rich" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00009" FT CARBOHYD 397 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT CARBOHYD 439 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498" FT DISULFID 31..64 FT /evidence="ECO:0000250|UniProtKB:P04347" FT DISULFID 107..328 FT /note="Interchain (between A and B chains)" FT /evidence="ECO:0000250|UniProtKB:P04347" FT CONFLICT 273 FT /note="Missing (in Ref. 3; AAC49787)" FT /evidence="ECO:0000305" FT CONFLICT 317..318 FT /note="RE -> LS (in Ref. 3; AAC49787)" FT /evidence="ECO:0000305" FT CONFLICT 387..390 FT /note="VNAN -> GNAK (in Ref. 3; AAC49787)" FT /evidence="ECO:0000305" SQ SEQUENCE 506 AA; 57793 MW; 0C785F3695C12F8B CRC64; MANKLLALSL FLLFSGCFAS TFRQQPQQNE CQFQRLNALE PDNSVKSEAG TIETWNPNND QLRCAGVALS RCTIQRNGLR RPFYTNAPQE IYIQQGRGIF GLIFPGCRET YEEPQEQEQG QGPRPQDRHQ KVEHFREGDI IAVPTGVPFW MYNNEQTPVI AITLIDTTNL DNQLDQIPRR FYLSGNQEQE FLQYQQKEGG QGQQQEGGNE GGNVLSGFND EFLEEAFSVD REIVRNIKGK NDDREGSIVE VKEGLKVISP PTLRPRQGRE EEEEEEEEEE ERRGDRRRHR PHHHEEEEEE EEWSHQVRRV RRPHHHREDR NGLEETLCTL KLRHNIGQST SPDAYNPQAG RLKTLTSLDF PILRWLGLAA EHGSIYKNAM FVPYYNVNAN SILYVLNGSA WFQVVDCSGN AVFNGELNEG QVLTIPQNYA VAIKSLDDNF SYVAFKTNDI PQIAALAGLT SSIRALPLDV VAHAFNLDRD QARQLKNNNP YKFLVPPPQS QLRAVA //