ID CONA1_LUPAN Reviewed; 506 AA. AC F5B8V6; Q96475; DT 16-JAN-2019, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2011, sequence version 1. DT 18-SEP-2019, entry version 30. DE RecName: Full=Conglutin alpha 1 {ECO:0000303|PubMed:21457583}; DE AltName: Allergen=Lup an alpha-conglutin {ECO:0000305}; DE Contains: DE RecName: Full=Conglutin alpha 1A subunit {ECO:0000250|UniProtKB:P04347}; DE Contains: DE RecName: Full=Conglutin alpha 1B subunit {ECO:0000250|UniProtKB:P04347}; DE Flags: Precursor; GN Name=CONALPHA {ECO:0000303|PubMed:9247543}; GN ORFNames=TanjilG_28353 {ECO:0000312|EMBL:OIW11262.1}; OS Lupinus angustifolius (Narrow-leaved blue lupine). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; OC 50 kb inversion clade; genistoids sensu lato; core genistoids; OC Genisteae; Lupinus. OX NCBI_TaxID=3871; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND RP ALLERGEN. RC STRAIN=cv. Tanjil; TISSUE=Seed; RX PubMed=21457583; DOI=10.1186/1471-2229-11-59; RA Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E., RA Smith P.M.C., Atkins C.A., Singh K.B.; RT "Identification and characterisation of seed storage protein RT transcripts from Lupinus angustifolius."; RL BMC Plant Biol. 11:59-59(2011). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Tanjil; TISSUE=Seedling; RX PubMed=27557478; DOI=10.1111/pbi.12615; RA Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A., RA Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R., RA Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W., RA McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.; RT "A comprehensive draft genome sequence for lupin (Lupinus RT angustifolius), an emerging health food: insights into plant-microbe RT interactions and legume evolution."; RL Plant Biotechnol. J. 15:318-330(2017). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] OF 267-397, TISSUE SPECIFICITY, AND RP DEVELOPMENTAL STAGE. RC STRAIN=cv. Unicrop; RX PubMed=9247543; DOI=10.1023/a:1005868105651; RA Ilgoutz S.C., Knittel N., Lin J.M., Sterle S., Gayler K.R.; RT "Transcription of genes for conglutin gamma and a leginsulin-like RT protein in narrow-leafed lupin."; RL Plant Mol. Biol. 34:613-627(1997). RN [4] RP SUBUNIT. RC STRAIN=cv. Zeus; RX PubMed=22264085; DOI=10.1021/jf2042592; RA Czubinski J., Dwiecki K., Siger A., Kachlicki P., Neunert G., RA Lampart-Szczapa E., Nogala-Kalucka M.; RT "Release of flavonoids from lupin globulin proteins during digestion RT in a model system."; RL J. Agric. Food Chem. 60:1830-1836(2012). CC -!- FUNCTION: Sulfur-rich seed storage protein. This protein found in CC the seeds of many leguminous and non-leguminous plants is the CC source of sulfur-containing amino acids in seed meals. CC {ECO:0000269|PubMed:21457583}. CC -!- SUBUNIT: Hexamer; each subunit is composed of an acidic and a CC basic chain derived from a single precursor and linked by a CC disulfide bond (By similarity). Component of globulins complexes CC which accumulate in seeds (Probable). CC {ECO:0000250|UniProtKB:P04347, ECO:0000305|PubMed:22264085}. CC -!- TISSUE SPECIFICITY: Expressed in developing cotyledons and in the CC embryonic axis of germinating seeds. {ECO:0000269|PubMed:9247543}. CC -!- DEVELOPMENTAL STAGE: Accumulates during seed development. CC {ECO:0000269|PubMed:21457583, ECO:0000269|PubMed:9247543}. CC -!- ALLERGEN: Causes an allergic reaction in human. CC {ECO:0000305|PubMed:21457583}. CC -!- SIMILARITY: Belongs to the 11S seed storage protein (globulins) CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ670406; AEB33709.1; -; mRNA. DR EMBL; CM007365; OIW11262.1; -; Genomic_DNA. DR EMBL; U74384; AAC49787.1; -; mRNA. DR Allergome; 7697; Lup an alpha_Conglutin. DR EnsemblPlants; OIW11262; OIW11262; TanjilG_28353. DR Gramene; OIW11262; OIW11262; TanjilG_28353. DR Proteomes; UP000188354; Chromosome LG05. DR Proteomes; UP000188354; Unassembled WGS sequence. DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW. DR Gene3D; 2.60.120.10; -; 3. DR InterPro; IPR022379; 11S_seedstore_CS. DR InterPro; IPR006044; 11S_seedstore_pln. DR InterPro; IPR006045; Cupin_1. DR InterPro; IPR014710; RmlC-like_jellyroll. DR InterPro; IPR011051; RmlC_Cupin_sf. DR Pfam; PF00190; Cupin_1; 2. DR PRINTS; PR00439; 11SGLOBULIN. DR SMART; SM00835; Cupin_1; 2. DR SUPFAM; SSF51182; SSF51182; 1. DR PROSITE; PS00305; 11S_SEED_STORAGE; 1. PE 1: Evidence at protein level; KW Allergen; Complete proteome; Disulfide bond; Glycoprotein; KW Reference proteome; Seed storage protein; Signal; Storage protein. FT SIGNAL 1 19 {ECO:0000255}. FT CHAIN 20 506 Conglutin alpha 1. FT /FTId=PRO_5011015128. FT CHAIN 20 321 Conglutin alpha 1A subunit. FT {ECO:0000250|UniProtKB:P04347}. FT /FTId=PRO_0000446133. FT CHAIN 322 506 Conglutin alpha 1B subunit. FT {ECO:0000250|UniProtKB:P04347}. FT /FTId=PRO_0000446134. FT COMPBIAS 187 205 Gln-rich. {ECO:0000255|PROSITE- FT ProRule:PRU00006}. FT COMPBIAS 270 302 Glu-rich. {ECO:0000255|PROSITE- FT ProRule:PRU00007}. FT COMPBIAS 282 320 Arg-rich. {ECO:0000255|PROSITE- FT ProRule:PRU00002}. FT COMPBIAS 289 316 His-rich. {ECO:0000255|PROSITE- FT ProRule:PRU00009}. FT CARBOHYD 397 397 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT CARBOHYD 439 439 N-linked (GlcNAc...) asparagine. FT {ECO:0000255|PROSITE-ProRule:PRU00498}. FT DISULFID 31 64 {ECO:0000250|UniProtKB:P04347}. FT DISULFID 107 328 Interchain (between A and B chains). FT {ECO:0000250|UniProtKB:P04347}. FT CONFLICT 273 273 Missing (in Ref. 3; AAC49787). FT {ECO:0000305}. FT CONFLICT 317 318 RE -> LS (in Ref. 3; AAC49787). FT {ECO:0000305}. FT CONFLICT 387 390 VNAN -> GNAK (in Ref. 3; AAC49787). FT {ECO:0000305}. SQ SEQUENCE 506 AA; 57793 MW; 0C785F3695C12F8B CRC64; MANKLLALSL FLLFSGCFAS TFRQQPQQNE CQFQRLNALE PDNSVKSEAG TIETWNPNND QLRCAGVALS RCTIQRNGLR RPFYTNAPQE IYIQQGRGIF GLIFPGCRET YEEPQEQEQG QGPRPQDRHQ KVEHFREGDI IAVPTGVPFW MYNNEQTPVI AITLIDTTNL DNQLDQIPRR FYLSGNQEQE FLQYQQKEGG QGQQQEGGNE GGNVLSGFND EFLEEAFSVD REIVRNIKGK NDDREGSIVE VKEGLKVISP PTLRPRQGRE EEEEEEEEEE ERRGDRRRHR PHHHEEEEEE EEWSHQVRRV RRPHHHREDR NGLEETLCTL KLRHNIGQST SPDAYNPQAG RLKTLTSLDF PILRWLGLAA EHGSIYKNAM FVPYYNVNAN SILYVLNGSA WFQVVDCSGN AVFNGELNEG QVLTIPQNYA VAIKSLDDNF SYVAFKTNDI PQIAALAGLT SSIRALPLDV VAHAFNLDRD QARQLKNNNP YKFLVPPPQS QLRAVA //