ID   CONA1_LUPAN             Reviewed;         506 AA.
AC   F5B8V6; Q96475;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   31-JUL-2019, entry version 29.
DE   RecName: Full=Conglutin alpha 1 {ECO:0000303|PubMed:21457583};
DE   AltName: Allergen=Lup an alpha-conglutin {ECO:0000305};
DE   Contains:
DE     RecName: Full=Conglutin alpha 1A subunit {ECO:0000250|UniProtKB:P04347};
DE   Contains:
DE     RecName: Full=Conglutin alpha 1B subunit {ECO:0000250|UniProtKB:P04347};
DE   Flags: Precursor;
GN   Name=CONALPHA {ECO:0000303|PubMed:9247543};
GN   ORFNames=TanjilG_28353 {ECO:0000312|EMBL:OIW11262.1};
OS   Lupinus angustifolius (Narrow-leaved blue lupine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae;
OC   50 kb inversion clade; genistoids sensu lato; core genistoids;
OC   Genisteae; Lupinus.
OX   NCBI_TaxID=3871;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
RP   ALLERGEN.
RC   STRAIN=cv. Tanjil; TISSUE=Seed;
RX   PubMed=21457583; DOI=10.1186/1471-2229-11-59;
RA   Foley R.C., Gao L.-L., Spriggs A., Soo L.Y.C., Goggin D.E.,
RA   Smith P.M.C., Atkins C.A., Singh K.B.;
RT   "Identification and characterisation of seed storage protein
RT   transcripts from Lupinus angustifolius.";
RL   BMC Plant Biol. 11:59-59(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Tanjil; TISSUE=Seedling;
RX   PubMed=27557478; DOI=10.1111/pbi.12615;
RA   Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA   Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA   Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA   McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT   "A comprehensive draft genome sequence for lupin (Lupinus
RT   angustifolius), an emerging health food: insights into plant-microbe
RT   interactions and legume evolution.";
RL   Plant Biotechnol. J. 15:318-330(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 267-397, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=cv. Unicrop;
RX   PubMed=9247543; DOI=10.1023/A:1005868105651;
RA   Ilgoutz S.C., Knittel N., Lin J.M., Sterle S., Gayler K.R.;
RT   "Transcription of genes for conglutin gamma and a leginsulin-like
RT   protein in narrow-leafed lupin.";
RL   Plant Mol. Biol. 34:613-627(1997).
RN   [4]
RP   SUBUNIT.
RC   STRAIN=cv. Zeus;
RX   PubMed=22264085; DOI=10.1021/jf2042592;
RA   Czubinski J., Dwiecki K., Siger A., Kachlicki P., Neunert G.,
RA   Lampart-Szczapa E., Nogala-Kalucka M.;
RT   "Release of flavonoids from lupin globulin proteins during digestion
RT   in a model system.";
RL   J. Agric. Food Chem. 60:1830-1836(2012).
CC   -!- FUNCTION: Sulfur-rich seed storage protein. This protein found in
CC       the seeds of many leguminous and non-leguminous plants is the
CC       source of sulfur-containing amino acids in seed meals.
CC       {ECO:0000269|PubMed:21457583}.
CC   -!- SUBUNIT: Hexamer; each subunit is composed of an acidic and a
CC       basic chain derived from a single precursor and linked by a
CC       disulfide bond (By similarity). Component of globulins complexes
CC       which accumulate in seeds (Probable).
CC       {ECO:0000250|UniProtKB:P04347, ECO:0000305|PubMed:22264085}.
CC   -!- TISSUE SPECIFICITY: Expressed in developing cotyledons and in the
CC       embryonic axis of germinating seeds. {ECO:0000269|PubMed:9247543}.
CC   -!- DEVELOPMENTAL STAGE: Accumulates during seed development.
CC       {ECO:0000269|PubMed:21457583, ECO:0000269|PubMed:9247543}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000305|PubMed:21457583}.
CC   -!- SIMILARITY: Belongs to the 11S seed storage protein (globulins)
CC       family. {ECO:0000305}.
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DR   EMBL; HQ670406; AEB33709.1; -; mRNA.
DR   EMBL; CM007365; OIW11262.1; -; Genomic_DNA.
DR   EMBL; U74384; AAC49787.1; -; mRNA.
DR   Allergome; 7697; Lup an alpha_Conglutin.
DR   EnsemblPlants; OIW11262; OIW11262; TanjilG_28353.
DR   Gramene; OIW11262; OIW11262; TanjilG_28353.
DR   Proteomes; UP000188354; Chromosome LG05.
DR   Proteomes; UP000188354; Unassembled WGS sequence.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR022379; 11S_seedstore_CS.
DR   InterPro; IPR006044; 11S_seedstore_pln.
DR   InterPro; IPR006045; Cupin_1.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF00190; Cupin_1; 2.
DR   PRINTS; PR00439; 11SGLOBULIN.
DR   SMART; SM00835; Cupin_1; 2.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS00305; 11S_SEED_STORAGE; 1.
PE   1: Evidence at protein level;
KW   Allergen; Complete proteome; Disulfide bond; Glycoprotein;
KW   Reference proteome; Seed storage protein; Signal; Storage protein.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    506       Conglutin alpha 1.
FT                                /FTId=PRO_5011015128.
FT   CHAIN        20    321       Conglutin alpha 1A subunit.
FT                                {ECO:0000250|UniProtKB:P04347}.
FT                                /FTId=PRO_0000446133.
FT   CHAIN       322    506       Conglutin alpha 1B subunit.
FT                                {ECO:0000250|UniProtKB:P04347}.
FT                                /FTId=PRO_0000446134.
FT   COMPBIAS    187    205       Gln-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00006}.
FT   COMPBIAS    270    302       Glu-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00007}.
FT   COMPBIAS    282    320       Arg-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00002}.
FT   COMPBIAS    289    316       His-rich. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00009}.
FT   CARBOHYD    397    397       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00498}.
FT   CARBOHYD    439    439       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00498}.
FT   DISULFID     31     64       {ECO:0000250|UniProtKB:P04347}.
FT   DISULFID    107    328       Interchain (between A and B chains).
FT                                {ECO:0000250|UniProtKB:P04347}.
FT   CONFLICT    273    273       Missing (in Ref. 3; AAC49787).
FT                                {ECO:0000305}.
FT   CONFLICT    317    318       RE -> LS (in Ref. 3; AAC49787).
FT                                {ECO:0000305}.
FT   CONFLICT    387    390       VNAN -> GNAK (in Ref. 3; AAC49787).
FT                                {ECO:0000305}.
SQ   SEQUENCE   506 AA;  57793 MW;  0C785F3695C12F8B CRC64;
     MANKLLALSL FLLFSGCFAS TFRQQPQQNE CQFQRLNALE PDNSVKSEAG TIETWNPNND
     QLRCAGVALS RCTIQRNGLR RPFYTNAPQE IYIQQGRGIF GLIFPGCRET YEEPQEQEQG
     QGPRPQDRHQ KVEHFREGDI IAVPTGVPFW MYNNEQTPVI AITLIDTTNL DNQLDQIPRR
     FYLSGNQEQE FLQYQQKEGG QGQQQEGGNE GGNVLSGFND EFLEEAFSVD REIVRNIKGK
     NDDREGSIVE VKEGLKVISP PTLRPRQGRE EEEEEEEEEE ERRGDRRRHR PHHHEEEEEE
     EEWSHQVRRV RRPHHHREDR NGLEETLCTL KLRHNIGQST SPDAYNPQAG RLKTLTSLDF
     PILRWLGLAA EHGSIYKNAM FVPYYNVNAN SILYVLNGSA WFQVVDCSGN AVFNGELNEG
     QVLTIPQNYA VAIKSLDDNF SYVAFKTNDI PQIAALAGLT SSIRALPLDV VAHAFNLDRD
     QARQLKNNNP YKFLVPPPQS QLRAVA
//