ID F5ANY9_9TELE Unreviewed; 156 AA. AC F5ANY9; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 28-JUN-2011, sequence version 1. DT 29-MAY-2024, entry version 29. DE SubName: Full=Isotocin {ECO:0000313|EMBL:AEB00560.1}; OS Amphiprion melanopus (fire clownfish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Pomacentridae; Amphiprion. OX NCBI_TaxID=229072 {ECO:0000313|EMBL:AEB00560.1}; RN [1] {ECO:0000313|EMBL:AEB00560.1} RP NUCLEOTIDE SEQUENCE. RA Kim J.M., Noh G.E.; RT "Molecular cloning and characterization of isotocin (IT) precursor cDNA RT from cinnamon clownfish (Amphiprion melanopus)."; RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. CC {ECO:0000256|ARBA:ARBA00007369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ441173; AEB00560.1; -; mRNA. DR AlphaFoldDB; F5ANY9; -. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0030141; C:secretory granule; IEA:TreeGrafter. DR GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro. DR Gene3D; 2.60.9.10; Neurohypophysial hormone domain; 1. DR InterPro; IPR000981; Neurhyp_horm. DR InterPro; IPR036387; Neurhyp_horm_dom_sf. DR InterPro; IPR022423; Neurohypophysial_hormone_CS. DR PANTHER; PTHR11681; NEUROPHYSIN; 1. DR PANTHER; PTHR11681:SF13; VASOTOCIN-NEUROPHYSIN; 1. DR Pfam; PF00184; Hormone_5; 1. DR PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1. DR PRINTS; PR00831; NEUROPHYSIN. DR SMART; SM00003; NH; 1. DR SUPFAM; SSF49606; Neurophysin II; 1. DR PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1. PE 2: Evidence at transcript level; KW Amidation {ECO:0000256|ARBA:ARBA00022815}; KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001815-50}; Hormone {ECO:0000256|ARBA:ARBA00022702}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..156 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5003321433" FT DISULFID 20..25 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 41..85 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 44..58 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 52..75 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 59..65 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 92..105 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 99..117 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" FT DISULFID 106..111 FT /evidence="ECO:0000256|PIRSR:PIRSR001815-50" SQ SEQUENCE 156 AA; 16288 MW; E53CFD10AF188FF3 CRC64; MTGAAVPICF LFLLSVCSAC YISNCPIGGK RSIIDAPLRK CMPCGPGDRG RCFGPSICCG EGLGCLLGSP ETAHCVEENY LLTPCQAGGR PCGSEGGRCA ASGLCCDAES CTTDQSCLIE EEGDDQSSQF EGSDPGDIIL RFLHLAGHTS PHRIHQ //