ID F4MHE0_HUMAN Unreviewed; 410 AA. AC F4MHE0; DT 28-JUN-2011, integrated into UniProtKB/TrEMBL. DT 22-JAN-2014, sequence version 2. DT 27-MAR-2024, entry version 45. DE RecName: Full=[histone H3]-trimethyl-L-lysine(27) demethylase {ECO:0000256|ARBA:ARBA00034525}; DE EC=1.14.11.68 {ECO:0000256|ARBA:ARBA00034525}; GN Name=UTY {ECO:0000313|EMBL:ABS19017.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS19017.1}; RN [1] {ECO:0000313|EMBL:ABS19017.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21329462; DOI=10.1089/omi.2010.0107; RA Laaser I., Theis F.J., de Angelis M.H., Kolb H.J., Adamski J.; RT "Huge splicing frequency in human Y chromosomal UTY gene."; RL OMICS 15:141-154(2011). CC -!- CATALYTIC ACTIVITY: CC Reaction=2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(27)- CC [histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L- CC lysyl(27)-[histone H3] + 2 succinate; Xref=Rhea:RHEA:60224, CC Rhea:RHEA-COMP:15535, Rhea:RHEA-COMP:15544, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:16842, CC ChEBI:CHEBI:30031, ChEBI:CHEBI:61929, ChEBI:CHEBI:61961; CC EC=1.14.11.68; Evidence={ECO:0000256|ARBA:ARBA00034421}; CC -!- COFACTOR: CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; CC Evidence={ECO:0000256|ARBA:ARBA00001961}; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the UTX family. {ECO:0000256|ARBA:ARBA00034483}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF685296; ABS19017.1; -; mRNA. DR PeptideAtlas; F4MHE0; -. DR ChiTaRS; UTY; human. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR PANTHER; PTHR14017:SF25; HISTONE DEMETHYLASE UTY; 1. DR PANTHER; PTHR14017; LYSINE-SPECIFIC DEMETHYLASE; 1. DR Pfam; PF13432; TPR_16; 2. DR Pfam; PF13181; TPR_8; 1. DR SMART; SM00028; TPR; 7. DR SUPFAM; SSF48452; TPR-like; 2. DR PROSITE; PS50005; TPR; 4. PE 2: Evidence at transcript level; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}. FT REPEAT 90..123 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 127..160 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 281..314 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 315..348 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT UNSURE 201 FT /note="D or N" FT /evidence="ECO:0000313|EMBL:ABS19017.1" SQ SEQUENCE 410 AA; 46649 MW; FCF00E8B3D48C6E0 CRC64; MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGXD SRLFGFVRLH EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN LLLEDYSKAL SAYQRYYSLQ ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF QDVLYVDPSF CRXKEIHLRL GLMFKVNTDY KSSLKHFQLA LIDCNPCTLS DAEIQFHIXH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA TVLQQLGWMH HNMDLVGDKA TKESYAIQYL QKSLEADPNS XQSWYFLGRC YSSIGKVQDA FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA AWMDLGTLYE SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQPSRRP VQSCQEEKNI //