ID F2WK21_ADE41 Unreviewed; 848 AA. AC F2WK21; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 24-JAN-2024, entry version 38. DE RecName: Full=Hexon protein {ECO:0000256|ARBA:ARBA00019716, ECO:0000256|RuleBase:RU361265}; DE Short=CP-H {ECO:0000256|RuleBase:RU361265}; DE AltName: Full=Protein II {ECO:0000256|ARBA:ARBA00032254, ECO:0000256|RuleBase:RU361265}; DE Flags: Fragment; OS Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41). OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus F. OX NCBI_TaxID=10524 {ECO:0000313|EMBL:AEA03235.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AEA03235.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=503214/KOL/2009 {ECO:0000313|EMBL:AEA03235.1}; RA Sharma-Dey R., Chawla-Sarkar M.; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AEA03235.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=503214/KOL/2009 {ECO:0000313|EMBL:AEA03235.1}; RX PubMed=21123530; DOI=10.1128/JCM.01834-10; RA Dey R.S., Ghosh S., Chawla-Sarkar M., Panchalingam S., Nataro J.P., Sur D., RA Manna B., Ramamurthy T.; RT "Circulation of a novel pattern of infections by enteric adenovirus RT serotype 41 among children below 5 years of age in Kolkata, India."; RL J. Clin. Microbiol. 49:500-505(2011). CC -!- FUNCTION: Major capsid protein that self-associates to form 240 hexon CC trimers, each in the shape of a hexagon, building most of the pseudo CC T=25 capsid. Assembled into trimeric units with the help of the CC chaperone shutoff protein. Transported by pre-protein VI to the nucleus CC where it associates with other structural proteins to form an empty CC capsid. Might be involved, through its interaction with host dyneins, CC in the intracellular microtubule-dependent transport of incoming viral CC capsid to the nucleus. {ECO:0000256|ARBA:ARBA00024662}. CC -!- SUBUNIT: Homotrimer. {ECO:0000256|RuleBase:RU361265}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. Virion CC {ECO:0000256|RuleBase:RU361265}. Host nucleus CC {ECO:0000256|RuleBase:RU361265}. CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle. CC {ECO:0000256|RuleBase:RU361265}. CC -!- SIMILARITY: Belongs to the adenoviridae hexon protein family. CC {ECO:0000256|ARBA:ARBA00008659, ECO:0000256|RuleBase:RU361265}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ005289; AEA03235.1; -; Genomic_DNA. DR GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule. DR Gene3D; 2.70.9.10; Adenovirus Type 2 Hexon, domain 4; 2. DR Gene3D; 3.90.39.10; Hexon Major Viral Coat Protein, domain 2; 1. DR Gene3D; 3.90.249.10; Hexon Major Viral Coat Protein, domain 3; 2. DR InterPro; IPR016108; Adenovirus_Pll_hexon_C. DR InterPro; IPR016107; Adenovirus_Pll_hexon_N. DR InterPro; IPR044942; Adenovirus_Pll_hexon_sub2. DR InterPro; IPR016110; Adenovirus_Pll_hexon_sub3. DR InterPro; IPR016112; VP_dsDNA_II. DR Pfam; PF01065; Adeno_hexon; 1. DR Pfam; PF03678; Adeno_hexon_C; 1. DR SUPFAM; SSF49749; Group II dsDNA viruses VP; 2. PE 2: Evidence at transcript level; KW Capsid protein {ECO:0000256|ARBA:ARBA00022561, KW ECO:0000256|RuleBase:RU361265}; KW Cytoplasmic inwards viral transport {ECO:0000256|ARBA:ARBA00023120}; KW Host nucleus {ECO:0000256|RuleBase:RU361265}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Late protein {ECO:0000256|RuleBase:RU361265}; KW Microtubular inwards viral transport {ECO:0000256|ARBA:ARBA00022952}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW T=25 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00023275, KW ECO:0000256|RuleBase:RU361265}; KW Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|RuleBase:RU361265}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}. FT DOMAIN 1..587 FT /note="Adenovirus Pll hexon N-terminal" FT /evidence="ECO:0000259|Pfam:PF01065" FT DOMAIN 588..809 FT /note="Adenovirus Pll hexon C-terminal" FT /evidence="ECO:0000259|Pfam:PF03678" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AEA03235.1" FT NON_TER 848 FT /evidence="ECO:0000313|EMBL:AEA03235.1" SQ SEQUENCE 848 AA; 95249 MW; A6EA9DE4633BEAA2 CRC64; YLSPGLVQFA RATDTYFSLG NKFRNPTVAP THDVTTDRSQ RLTLRFVPVD REDTAYSYKV RFTLAVGDNR VLDMASTYFD IRGVLDRGPS FKPYSGTAYN SLAPKTAPNP CEWKDNNNKI KVRGQAPLIG TNIDKDNGIQ IGTDATKPIY ADKTYQPEPQ VGQTQWNSEV GATDKVAGRV LKDTTPMLPC YGSYAQPTNE KGGQANLITN GTDQTLTSDV NLQFFALANT PNVPKAVLYA ENVTIEAPDT HLVYKPDVAQ GTVSSADLLT QQAAPNRPNY IGFRDNFIGL MYYNSTGNMG VLAGQASQLN AVVDLQDRNT ELSYQLMLDA LGDRSRYFSM WNQAVDSYDP DVRIIENHGV EDELPNYCFP LGGSAATDTY SGIKANSGNW TADNDTYADR GAEIESGNIF AMEINLAANL WRSFLYSNVA LYLPDSYKIT PDNITLPENK NTYAYMNGRV AVPSALDTYV NIGARWSPDP MDNVNPFNHH RNAGLRYRSM LLGNGRYVPF HIQVPQKFFA IKNLLLLPGS YTYEWNFRKD VNMILQSSLG NDLRVDGASV RFDSINLYAN FFPMAHNTAS TLEAMLRNDT NDQSFNDYLC AANMLYPIPS NATSVPISIP SRNWAAFRGW SFTRLKTKET PSLGSGFDPY FTYSGSVPYL DGTFYLNHTF KKVSIMFDSS VSWPGNDRLL TPNEFEIKRT VDGEGYNVAQ CNMTKDWFLI QMLSHYNIGY QGFYVPESYK DRMYSFFRNF QPMSRQVVNT TTYKEYQNVT LPFQHNNSGF VGYMGPTMRE GQAYPANYPY PLIGQTAVPS LTQKKFLCDR TMWRIPFSSN FMSMGALTDL GQNMLYAN //