ID F2WK21_ADE41 Unreviewed; 848 AA. AC F2WK21; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 28-MAR-2018, entry version 18. DE RecName: Full=Hexon protein {ECO:0000256|RuleBase:RU361265}; DE Short=CP-H {ECO:0000256|RuleBase:RU361265}; DE AltName: Full=Protein II {ECO:0000256|RuleBase:RU361265}; DE Flags: Fragment; OS Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41). OC Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus; OC Human mastadenovirus F. OX NCBI_TaxID=10524 {ECO:0000313|EMBL:AEA03235.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AEA03235.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=503214/KOL/2009 {ECO:0000313|EMBL:AEA03235.1}; RA Sharma-Dey R., Chawla-Sarkar M.; RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AEA03235.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=503214/KOL/2009 {ECO:0000313|EMBL:AEA03235.1}; RX PubMed=21123530; DOI=10.1128/JCM.01834-10; RA Dey R.S., Ghosh S., Chawla-Sarkar M., Panchalingam S., Nataro J.P., RA Sur D., Manna B., Ramamurthy T.; RT "Circulation of a novel pattern of infections by enteric adenovirus RT serotype 41 among children below 5 years of age in Kolkata, India."; RL J. Clin. Microbiol. 49:500-505(2011). CC -!- FUNCTION: Major capsid protein that self-associates to form 240 CC hexon trimers, each in the shape of a hexagon, building most of CC the pseudo T=25 capsid. {ECO:0000256|RuleBase:RU361265}. CC -!- SUBUNIT: Homotrimer. {ECO:0000256|RuleBase:RU361265}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|RuleBase:RU361265}. Host CC nucleus {ECO:0000256|RuleBase:RU361265}. CC -!- INDUCTION: Expressed in the late phase of the viral replicative CC cycle. {ECO:0000256|RuleBase:RU361265}. CC -!- SIMILARITY: Belongs to the adenoviridae hexon protein family. CC {ECO:0000256|RuleBase:RU361265}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; HQ005289; AEA03235.1; -; Genomic_DNA. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0039623; C:T=25 icosahedral viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule. DR Gene3D; 2.70.9.10; -; 1. DR InterPro; IPR016108; Adenovirus_Pll_hexon_C. DR InterPro; IPR016107; Adenovirus_Pll_hexon_N. DR InterPro; IPR016111; Hexon_subdom4. DR InterPro; IPR016112; VP_dsDNA_II. DR Pfam; PF01065; Adeno_hexon; 1. DR Pfam; PF03678; Adeno_hexon_C; 1. DR SUPFAM; SSF49749; SSF49749; 2. PE 2: Evidence at transcript level; KW Capsid protein {ECO:0000256|RuleBase:RU361265}; KW Host nucleus {ECO:0000256|RuleBase:RU361265}; KW Late protein {ECO:0000256|RuleBase:RU361265}; KW T=25 icosahedral capsid protein {ECO:0000256|RuleBase:RU361265}; KW Virion {ECO:0000256|RuleBase:RU361265}. FT DOMAIN 23 529 Adeno_hexon. {ECO:0000259|Pfam:PF01065}. FT DOMAIN 588 809 Adeno_hexon_C. {ECO:0000259|Pfam: FT PF03678}. FT NON_TER 1 1 {ECO:0000313|EMBL:AEA03235.1}. FT NON_TER 848 848 {ECO:0000313|EMBL:AEA03235.1}. SQ SEQUENCE 848 AA; 95249 MW; A6EA9DE4633BEAA2 CRC64; YLSPGLVQFA RATDTYFSLG NKFRNPTVAP THDVTTDRSQ RLTLRFVPVD REDTAYSYKV RFTLAVGDNR VLDMASTYFD IRGVLDRGPS FKPYSGTAYN SLAPKTAPNP CEWKDNNNKI KVRGQAPLIG TNIDKDNGIQ IGTDATKPIY ADKTYQPEPQ VGQTQWNSEV GATDKVAGRV LKDTTPMLPC YGSYAQPTNE KGGQANLITN GTDQTLTSDV NLQFFALANT PNVPKAVLYA ENVTIEAPDT HLVYKPDVAQ GTVSSADLLT QQAAPNRPNY IGFRDNFIGL MYYNSTGNMG VLAGQASQLN AVVDLQDRNT ELSYQLMLDA LGDRSRYFSM WNQAVDSYDP DVRIIENHGV EDELPNYCFP LGGSAATDTY SGIKANSGNW TADNDTYADR GAEIESGNIF AMEINLAANL WRSFLYSNVA LYLPDSYKIT PDNITLPENK NTYAYMNGRV AVPSALDTYV NIGARWSPDP MDNVNPFNHH RNAGLRYRSM LLGNGRYVPF HIQVPQKFFA IKNLLLLPGS YTYEWNFRKD VNMILQSSLG NDLRVDGASV RFDSINLYAN FFPMAHNTAS TLEAMLRNDT NDQSFNDYLC AANMLYPIPS NATSVPISIP SRNWAAFRGW SFTRLKTKET PSLGSGFDPY FTYSGSVPYL DGTFYLNHTF KKVSIMFDSS VSWPGNDRLL TPNEFEIKRT VDGEGYNVAQ CNMTKDWFLI QMLSHYNIGY QGFYVPESYK DRMYSFFRNF QPMSRQVVNT TTYKEYQNVT LPFQHNNSGF VGYMGPTMRE GQAYPANYPY PLIGQTAVPS LTQKKFLCDR TMWRIPFSSN FMSMGALTDL GQNMLYAN //