ID F2CCR8_STRSA Unreviewed; 124 AA. AC F2CCR8; DT 31-MAY-2011, integrated into UniProtKB/TrEMBL. DT 31-MAY-2011, sequence version 1. DT 22-FEB-2023, entry version 38. DE RecName: Full=Putative fluoride ion transporter CrcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN Name=crcB2 {ECO:0000313|EMBL:EGF19828.1}; GN Synonyms=crcB {ECO:0000256|HAMAP-Rule:MF_00454}; GN ORFNames=HMPREF9391_0548 {ECO:0000313|EMBL:EGF19828.1}; OS Streptococcus sanguinis SK408. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=888818 {ECO:0000313|EMBL:EGF19828.1, ECO:0000313|Proteomes:UP000004826}; RN [1] {ECO:0000313|EMBL:EGF19828.1, ECO:0000313|Proteomes:UP000004826} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SK408 {ECO:0000313|EMBL:EGF19828.1, RC ECO:0000313|Proteomes:UP000004826}; RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G., RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., RA Petrosino J., Highlander S., Gibbs R.; RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Important for reducing fluoride concentration in the cell, CC thus reducing its toxicity. {ECO:0000256|ARBA:ARBA00004023, CC ECO:0000256|HAMAP-Rule:MF_00454}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00454}; CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00454}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the CrcB (TC 9.B.71) family. CC {ECO:0000256|ARBA:ARBA00007610, ECO:0000256|HAMAP-Rule:MF_00454}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EGF19828.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AFBE01000002; EGF19828.1; -; Genomic_DNA. DR RefSeq; WP_002917150.1; NZ_GL878559.1. DR AlphaFoldDB; F2CCR8; -. DR EnsemblBacteria; EGF19828; EGF19828; HMPREF9391_0548. DR PATRIC; fig|888818.3.peg.532; -. DR HOGENOM; CLU_114342_3_3_9; -. DR Proteomes; UP000004826; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:1903425; F:fluoride transmembrane transporter activity; IEA:UniProt. DR HAMAP; MF_00454; CrcB; 1. DR InterPro; IPR003691; CrcB. DR PANTHER; PTHR28259; FLUORIDE EXPORT PROTEIN 1-RELATED; 1. DR PANTHER; PTHR28259:SF1; FLUORIDE EXPORT PROTEIN 1-RELATED; 1. DR Pfam; PF02537; CRCB; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_00454}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00454}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_00454}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_00454}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00454}. FT TRANSMEM 7..30 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 36..54 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 66..85 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" FT TRANSMEM 100..119 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00454" SQ SEQUENCE 124 AA; 13260 MW; 4D53253598957D72 CRC64; MKEVQNSIAV ALSAMVGGWL RYQIALLLVV ADSFPLGTLL VNYLGTFLLV YIIKGYLSSK VKSQRLILAL STGFCGGLTT FSGLLLDSIK LADSGRYMEL LIYLVLSVGG GLAIALWAGK QVKS //